RESUMEN
An immunoenzymatic assay (Epo-Eia) has been used in order to evaluate the seric Epo level in beta-thalassemic heterozygous subjects. The present results lead one to conclude that serum Epo levels in thalassemic subjects are higher than in normal subjects and that the differences between thalassemic and normal females are highly significant statistically (p < 0.01). The Epo levels in thalassemic females are also higher than those in thalassemic males (0.01 < p < 0.05). Differences in Epo levels may be observed between thalassemic and normal males although they are not highly significant statistically. No correlations seem to exist between Epo and Hb values.
Asunto(s)
Eritropoyetina/sangre , Heterocigoto , Talasemia beta/sangre , Adulto , Femenino , Humanos , Técnicas para Inmunoenzimas , Masculino , Persona de Mediana Edad , Caracteres Sexuales , Talasemia beta/genéticaRESUMEN
In guinea pig bone marrow cultures with heterozygous alpha-thalassemic serum, 59Fe uptake values are elevated above iron values of cultures with serum of normal subjects. These results show that erythropoietin (EP) activity values in heterozygous alpha-thalassemia are comparable to those previously observed by ourselves in heterozygous beta-thalassemia despite of the different Hb concentration in these thalassemic syndromes. This points to the existence of signals which regulate Ep synthesis independently of Hb levels.
Asunto(s)
Eritropoyetina/sangre , Talasemia/sangre , Adolescente , Adulto , Niño , Femenino , Heterocigoto , Humanos , Masculino , Persona de Mediana Edad , Talasemia/genéticaRESUMEN
In the present work the capacity of serum of beta-thalassemic heterozygous and normal subjects to stimulate 59Fe uptake into heme in guinea pig bone marrow cultures is analyzed. The results show that labelled iron uptake is higher in cultures with thalassemic serum than in cultures with normal serum. No correlation between labelled iron uptake and Hb level or sex has been found in either group.
