1.
Org Biomol Chem
; 22(1): 169-174, 2023 Dec 20.
Artículo
en Inglés
| MEDLINE
| ID: mdl-38051284
RESUMEN
3-Aryl-4-aminomaleimides have well-demonstrated applications, such as being used as fluorophores and inhibitors. However, their previous synthesis methods have involved tedious multi-step procedures or methods that need pre-functionalized maleimides and toxic or unstable reagents. Here, a feasible method is developed to synthesize these useful compounds. This includes the one-pot preparation of 3-aminomaleimides, followed by their direct arylation through a palladium-catalyzed Heck reaction with various aryl iodides regioselectively at the ß-position of their amine substituents. The results show that this method efficiently exhibits a broad scope.