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1.
Opt Express ; 30(9): 13959-13967, 2022 Apr 25.
Artículo en Inglés | MEDLINE | ID: mdl-35473149

RESUMEN

Dispersion impairments are a well-known limitation in data center communications, limiting both the usable data rates and reaches. Several companies today adopt silicon photonics as a core technology in their transceiver products. This presents an opportunity for silicon photonics-based dispersion management technologies to be integrated with the transceiver transmitter or receiver. In this manuscript, we present a ring-resonator based, tunable dispersion compensation device, providing dispersion ranging as wide from + 12.9 × 103ps/nm to -12.3 × 103ps/nm. Thermo-optic tuning from 20°C to 70°C is demonstrated to allow continuous wavelength tuning across 200 GHz. High-speed experiments using 25 Gb/s non-return-to-zero data propagating through 20 km of single mode fiber show that a significant improvement in the eye diagram is achieved after compensation with the ring-resonator device. We demonstrate a significant improvement in the BER from 10-3 to 10-11 for data rates of 25 and 25.78125 Gb/s.

2.
Sci Rep ; 11(1): 21292, 2021 Oct 28.
Artículo en Inglés | MEDLINE | ID: mdl-34711919

RESUMEN

Infrared (IR)-emitting RE doped materials have been extensively used to fabricate active components of integrated optical devices in various fields, such as fiber amplifiers, telecommunications, optoelectronics, and waveguides. Among various RE elements, trivalent erbium ions (Er 3+) are of great interest since their emissive behavior span the low loss telecommunication window of 1300-1650 nm. In this paper, we report two types of polymeric waveguide amplifiers. 8 cm long, lithographically patterned spiral waveguides provide 8 dB of gain using a 980 nm pump power of 95 mW. Gain is observed from 1530 to 1590 nm. We further report the first demonstration of polymeric waveguide amplifiers fabricated using 3D printing methods based on two-photon lithography, paving the way for rapid prototyping of active 3D printed devices and active photonic devices which may transcend planar limitations.

3.
Opt Lett ; 42(21): 4450-4453, 2017 Nov 01.
Artículo en Inglés | MEDLINE | ID: mdl-29088185

RESUMEN

We report on the design and experimental demonstration of a broadband silicon polarization beam splitter (PBS) with a high extinction ratio (ER)≥30 dB. This was achieved using triple-bent-waveguide directional coupling in a single PBS, and cascaded PBS topology. For the single PBS, the bandwidths for an ER≥30 dB are 20 nm for the quasi-TE mode, and 70 nm for the quasi-TM mode when a broadband light source (1520-1610 nm) was employed. The insertion loss (IL) varies from 0.2 to 1 dB for the quasi-TE mode and 0.2-2 dB for the quasi-TM mode. The cascaded PBS improved the bandwidth of the quasi-TE mode for an ER≥30 dB to 90 nm, with a low IL of 0.2-2 dB. To the best of our knowledge, our PBS system is one of the best broadband PBSs with an ER as high as ∼42 dB and a low IL below 1 dB around the central wavelength, and experimentally demonstrated using edge-coupling.

4.
Sci Rep ; 7(1): 9101, 2017 08 22.
Artículo en Inglés | MEDLINE | ID: mdl-28831178

RESUMEN

Ring resonators on silicon rich nitride for potential use as rare-earth doped amplifiers pumped at 1310 nm with amplification at telecommunications-band are designed and characterized. The ring resonators are fabricated on 300 nm and 400 nm silicon rich nitride films and characterized at both 1310 nm and 1550 nm. We demonstrate ring resonators exhibiting similar quality factors exceeding 10,000 simultaneously at 1310 nm and 1550 nm. A Dysprosium-Erbium material system exhibiting photoluminescence at 1510 nm when pumped at 1310 nm is experimentally demonstrated. When used together with Dy-Er co-doped particles, these resonators with similar quality factors at 1310 nm and 1550 nm may be used for O-band pumped amplifiers for the telecommunications-band.

5.
Nat Commun ; 8: 13878, 2017 01 04.
Artículo en Inglés | MEDLINE | ID: mdl-28051064

RESUMEN

CMOS platforms operating at the telecommunications wavelength either reside within the highly dissipative two-photon regime in silicon-based optical devices, or possess small nonlinearities. Bandgap engineering of non-stoichiometric silicon nitride using state-of-the-art fabrication techniques has led to our development of USRN (ultra-silicon-rich nitride) in the form of Si7N3, that possesses a high Kerr nonlinearity (2.8 × 10-13 cm2 W-1), an order of magnitude larger than that in stoichiometric silicon nitride. Here we experimentally demonstrate high-gain optical parametric amplification using USRN, which is compositionally tailored such that the 1,550 nm wavelength resides above the two-photon absorption edge, while still possessing large nonlinearities. Optical parametric gain of 42.5 dB, as well as cascaded four-wave mixing with gain down to the third idler is observed and attributed to the high photon efficiency achieved through operating above the two-photon absorption edge, representing one of the largest optical parametric gains to date on a CMOS platform.

6.
Opt Express ; 23(6): 8095-103, 2015 Mar 23.
Artículo en Inglés | MEDLINE | ID: mdl-25837147

RESUMEN

Multiplexing of optical modes in waveguides is demonstrated using coupled vertical gratings. The device utilizes sinusoidally corrugated waveguides of different widths with a period designed to multiplex information at 1.55 µm. The design, fabrication and characterization of devices is performed. Multiplexing of modes is demonstrated in optical structures which support 3 and 5 quasi-TE modes. The design utilizes counter-propagating modes in periodic structures, thus enabling the device to combine its mode division multiplexing capabilities with wavelength division multiplexing functionalities to further augment the multiplexing capacity of the device.

7.
Opt Express ; 22(9): 10408-15, 2014 May 05.
Artículo en Inglés | MEDLINE | ID: mdl-24921742

RESUMEN

A 1 by 4 wavelength division multiplexer with 0.5nm bandwidth and no free spectral range limitation is demonstrated on silicon. The device utilizes wide bandwidth filters cascaded with ring resonators in order to select specific ring resonator modes and route each resonant mode to a separate port. This technology will enable dense wavelength division multiplexing covering the C - and L - bands with up to 100 10GB/s channels separated by 100GHz to be implemented for optical interconnects applications. A 1 by 4 wavelength division multiplexer with 3dB channel bandwidths as small as 0.5nm and 1dB insertion loss are demonstrated with 16dB inter-channel crosstalk suppression. A second wavelength division multiplexer scheme with four channels, each spaced 0.5nm apart without any free spectral range limitations is also demonstrated using wide bandwidth filters centered at the same wavelength to select resonances from four different ring resonators with slightly different widths.

8.
Appl Opt ; 52(4): 613-24, 2013 Feb 01.
Artículo en Inglés | MEDLINE | ID: mdl-23385898

RESUMEN

This paper reviews recent work in the area of silicon photonic devices and circuits for monolithic and heterogeneous integration of circuits and systems on a chip. In this context, it presents fabrication results for producing low-loss silicon waveguides without etching. Resonators and add-drop distributed filters utilizing sidewall modulation fabricated in a single lithography and etching step are demonstrated. It also presents an optical pulse compressor that monolithically integrates self-phase modulation and anomalous dispersion compensation devices on a silicon chip. As an example of heterogeneous integration, we demonstrate vertical emitting metallo-dielectric nanolasers integrated onto a silicon platform. Future research directions toward large-scale photonic circuits and systems on a chip also are discussed.

9.
Opt Express ; 21(24): 29223-30, 2013 Dec 02.
Artículo en Inglés | MEDLINE | ID: mdl-24514474

RESUMEN

The simultaneous generation of second and third order dispersion is demonstrated using nonlinearly chirped silicon waveguide gratings. The nonlinearly chirped gratings are designed to generate varying signs and magnitudes of group velocity dispersion and dispersion slope. The design, fabrication, and experimental characterization of the silicon waveguide gratings are performed. Second order dispersion as high as -2.3 X 106 ps/nm²/km and third order dispersion as high as 1.2 X 105 ps/nm²/km and as low as 1.2 X 104 ps/nm²/km is demonstrated at 1.55 µm.

10.
Ultrasound Obstet Gynecol ; 38(5): 533-7, 2011 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-21557370

RESUMEN

OBJECTIVE: To evaluate the degree of agreement in first-trimester nasal bone assessment in a group of sonographers before and after training, using a semi-quantitative scoring system. METHODS: Four sonographers who routinely perform first-trimester screening were first shown 46 images from both normal and trisomy 21 pregnancies. For each image, they were asked to score from 0 (disagree) to 3 (agree) on five different criteria that were deemed important in nasal-bone assessment, including image size, plane and visibility of nasal bone. A training program was then conducted, and a repeat exercise was carried out using the same 46 images. Finally, in a third exercise, images from 42 patients were presented, some having more than one image. The sonographers were required to give one overall nasal-bone score for each patient. In each exercise interobserver agreement was evaluated by intraclass correlation coefficient (ICC). RESULTS: Before training, the sonographers agreed reasonably well on the five proposed criteria (ICC, 0.752), with some disagreement on their perceived image quality. The training program further improved the agreement (ICC, 0.790), particularly on whether the nasal bone was the biggest and brightest echogenic component. Agreement was excellent when they were asked to give one overall score on the nasal bone based on multiple images from one patient (ICC, 0.929). CONCLUSION: The proposed scoring system can be used to improve consistency and reliability in first-trimester nasal-bone assessment.


Asunto(s)
Síndrome de Down/diagnóstico por imagen , Hueso Nasal/diagnóstico por imagen , Primer Trimestre del Embarazo , Ultrasonografía Prenatal/métodos , Síndrome de Down/embriología , Femenino , Humanos , Hueso Nasal/embriología , Variaciones Dependientes del Observador , Embarazo , Garantía de la Calidad de Atención de Salud , Reproducibilidad de los Resultados , Encuestas y Cuestionarios
11.
Opt Express ; 19(3): 2401-9, 2011 Jan 31.
Artículo en Inglés | MEDLINE | ID: mdl-21369058

RESUMEN

We demonstrate an add/drop filter based on coupled vertical gratings on silicon. Tailoring of the channel bandwidth and wavelength is experimentally demonstrated. The concept is extended to implement a 1 by 4 wavelength division multiplexer with 6 nm channel separation, 3 nm bandwidth, a flat top response with < 0.8 dB ripple within the 3 dB passband, 1 dB insertion loss and 16 dB crosstalk suppression. The device is ultracompact, having a footprint < 2 X 10(-9)/2.


Asunto(s)
Dispositivos Ópticos , Refractometría/instrumentación , Silicio/química , Telecomunicaciones/instrumentación , Diseño Asistido por Computadora , Diseño de Equipo , Análisis de Falla de Equipo , Miniaturización
12.
Br J Ophthalmol ; 94(10): 1295-9, 2010 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-20829318

RESUMEN

AIM: To compare visual outcomes between deep anterior lamellar keratoplasty (DALK) and penetrating keratoplasty (PK). Secondarily to compare refractive outcomes, complications and graft survival between the three cohorts. METHODS: Retrospective case-control study evaluating visual acuity outcomes (VA) following DALK with complete Descemet's baring (DALKa) (modified Anwar big bubble technique--51 eyes), pre-descemetic anterior lamellar keratoplasty (DALKm) (manual technique--52 eyes) and PK (103 eyes) with mean follow-up of 13.6, 19.3 and 18.6 months, respectively. RESULTS: The common indications for surgery were corneal scars (36.4%), keratoconus (28.6%) and corneal dystrophies (13.6%). A best-corrected VA of 6/7.5 or better was achieved in 19.4% (PK), 21.6% (DALKm) and 38.5% (DALKa) of cases (p=0.02), and eyes that underwent DALKa had significantly better visual outcomes than PK (p=0.03). Complications following PK were glaucoma (15%), endothelial rejection (12%) and epithelial problems (11%); in the lamellar group, glaucoma (9%), epithelial problems (5%) and Descemet's detachment (3%) were more common. The 2-year estimated probability of graft survival was 90% for PK, 98% for DALKm and 100.0% for DALKa (p=0.35). CONCLUSIONS: Lamellar keratoplasty with complete baring of the Descemet's membrane (DALKa) gave significantly better visual outcomes compared to PK or pre-descemetic ALK and should be the preferred from of corneal replacement in corneal disorders with healthy endothelium.


Asunto(s)
Enfermedades de la Córnea/cirugía , Trasplante de Córnea/métodos , Agudeza Visual/fisiología , Adulto , Análisis de Varianza , Estudios de Casos y Controles , Enfermedades de la Córnea/fisiopatología , Supervivencia de Injerto , Humanos , Estimación de Kaplan-Meier , Complicaciones Posoperatorias/etiología , Complicaciones Posoperatorias/fisiopatología , Errores de Refracción/etiología , Errores de Refracción/fisiopatología , Estudios Retrospectivos , Resultado del Tratamiento
13.
Opt Lett ; 34(9): 1357-9, 2009 May 01.
Artículo en Inglés | MEDLINE | ID: mdl-19412271

RESUMEN

A cladding-modulated Bragg grating implemented using periodic placements of cylinders along a waveguide is proposed in a silicon-on-insulator platform. The coupling strength is varied by changing the distance between the cylinders and the waveguide. This implementation enables precise control and a wide dynamic range of coupling strengths and bandwidths that can be practically achieved for applications with specific bandwidth requirements. Modeling results are verified experimentally, and we demonstrate coupling strengths differing by 1 order of magnitude (43 and 921 per cm) with bandwidths of 8 and 16 nm, respectively. This method scheme enables weakly coupled devices with high fabrication tolerance to be realized.

14.
Br J Ophthalmol ; 93(7): 926-31, 2009 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-19429578

RESUMEN

BACKGROUND: To describe the underlying molecular genetic basis, surgical management and phenotypic variation of Schnyder corneal dystrophy (SCD) identified in a four-generation Chinese family. METHODS: This is an interventional case series of 13 members from a non-consanguineous Chinese family. All patients underwent complete ophthalmological examination and slit-lamp photography. Subsequent corneal transplantations were performed (n = 3). Blood samples were taken for DNA extraction and subsequent genetic analysis. RESULTS: Genotyping indicated linkage to the locus at chromosome 1p36. Screening of the UBIAD1 gene identified a highly conserved mutation, Ser171Pro. Phenotypic variation in this large pedigree is similar to that seen in Caucasian patients. Surgical management of patients with anterior lamellar keratoplasty and deep anterior lamellar keratoplasty showed good visual outcomes. CONCLUSIONS: The S171P mutation is described for the first time in a Chinese family. This is the largest non-Caucasian pedigree described with SCD. Visual rehabilitation may be performed successfully with lamellar surgical procedures as opposed to full-thickness corneal grafts.


Asunto(s)
Distrofias Hereditarias de la Córnea/genética , Mutación Puntual/genética , Proteínas/genética , Adulto , Anciano , Anciano de 80 o más Años , Pueblo Asiatico , Distrofias Hereditarias de la Córnea/cirugía , Trasplante de Córnea , Análisis Mutacional de ADN , Dimetilaliltranstransferasa , Femenino , Ligamiento Genético , Predisposición Genética a la Enfermedad , Humanos , Persona de Mediana Edad , Linaje , Fenotipo , Tomografía de Coherencia Óptica , Agudeza Visual
15.
Br J Ophthalmol ; 93(3): 299-304, 2009 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-18927226

RESUMEN

AIM: The aim of the study was to describe the prevalence and visual outcomes of cataract surgery in an urban Asian population. METHODS: This was a population-based study of 3280 Singapore Malays aged 40-80 years (response rate 78.7%). Participants had a standardised interview and comprehensive ocular examination. Poor post-operative visual outcome was defined as visual acuity

Asunto(s)
Extracción de Catarata/estadística & datos numéricos , Adulto , Anciano , Anciano de 80 o más Años , Estudios Transversales , Femenino , Humanos , Masculino , Persona de Mediana Edad , Prevalencia , Singapur/epidemiología , Resultado del Tratamiento , Población Urbana/estadística & datos numéricos , Agudeza Visual
16.
Opt Lett ; 33(24): 3013-5, 2008 Dec 15.
Artículo en Inglés | MEDLINE | ID: mdl-19079525

RESUMEN

A strongly coupled, chirped Bragg grating made by sinusoidally modulating the sidewalls of a silicon waveguide is designed, fabricated, and experimentally characterized. By varying the device parameters, the operating wavelength, device bandwidth, sign (normal or anomalous), and magnitude of group-velocity dispersion may be engineered for specific photonic applications. Asymmetric Blackman apodization is best suited for maximizing the useable bandwidth while providing good ripple suppression. Dispersion values up to 7.0 x 10(5) ps/nm/km are demonstrated at 1.55 microm.

18.
Int J Oral Maxillofac Surg ; 36(9): 807-13, 2007 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-17630251

RESUMEN

The aim of this retrospective study was to describe the oral procedures used in osteo-odonto-keratoprosthesis (OOKP) surgery, and the demographics and oral findings of candidate patients in Singapore. The OOKP procedure utilizes an autologous tooth-bone complex to mount a poly-methylmethacrylate optical cylinder, as an artificial cornea, stabilized by an overlying autologous buccal mucosal graft. Consecutive patients referred over 3 years for dental evaluation prior to OOKP surgery were included. A total of 21 patients underwent oral clinical and radiographic evaluation. The aetiology of blindness included Stevens-Johnson's syndrome (11 cases), chemical burns (9 cases) and multiple failed corneal grafts (1 case). Evaluation revealed that 12 patients were suitable for OOKP surgery, 8 were at risk of complication or failure and 1 had no usable teeth. Fourteen patients have undergone unilateral OOKP Stage 1 surgery successfully. Complications included fracture of a tooth from its lingual bone necessitating the harvesting of a second tooth (1 case), oronasal perforation (1 case), exposure of adjacent roots (5 teeth), lower lip paresthesia (2 cases) and submucosal scar band formation in the buccal mucosal graft donor site (10 cases). Thirteen patients have completed Stage 2 surgery, with attainment of their best possible visual potential following OOKP surgery.


Asunto(s)
Proceso Alveolar/trasplante , Bioprótesis , Ceguera/cirugía , Procedimientos Quirúrgicos Orales/métodos , Implantes Orbitales , Raíz del Diente/trasplante , Adolescente , Adulto , Ceguera/rehabilitación , Trasplante Óseo/métodos , Córnea/patología , Córnea/cirugía , Opacidad de la Córnea/cirugía , Femenino , Humanos , Masculino , Persona de Mediana Edad , Procedimientos Quirúrgicos Oftalmológicos/métodos , Osteotomía/métodos , Diseño de Prótesis , Implantación de Prótesis/métodos , Procedimientos de Cirugía Plástica/métodos , Refracción Ocular , Estudios Retrospectivos
19.
Br J Ophthalmol ; 90(10): 1230-5, 2006 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-16809384

RESUMEN

AIM: To compare the prevalences of refractive errors in Malay, Chinese and Indian children in Malaysia and Singapore. METHODS: Children aged 7-9 years from three schools in the Singapore Cohort study of the Risk factors for Myopia (n = 1962) and similarly aged children from a random cluster sample in the metropolitan Kuala Lumpur area in the Malaysia Refractive Error Study in Children (n = 1752) were compared. Cycloplegic autorefraction was conducted in both countries. RESULTS: The prevalence of myopia (spherical equivalent of at least -0.5 diopters (D) in either eye) was higher in Singapore Malays (22.1%) than in Malays in Malaysia (9.2%; 95% confidence interval (CI) 11.2 to 14.7; p<0.001). Similarly, Singapore Chinese (40.1%) had higher prevalences than Malaysian Chinese (30.9%; 95% CI 1.5 to 16.9). Singapore Indians had a higher prevalence (34.1%) than Malaysian Indians (12.5%; 95% CI 17.4 to 25.9). The multivariate odds ratio of astigmatism (cylinder at least 0.75 D in either eye) in Singapore Malays compared with Malaysian Malays was 3.47 (95% CI 2.79 to 4.32). Ethnicity-specific hyperopia rates did not differ in Singapore and Malaysia. CONCLUSION: The ethnicity-specific prevalences of myopia in Singapore Malays, Chinese and Indians are higher than those in Malaysian Malays, Chinese and Indians. As Malays, Chinese and Indians in Malaysia have genetic make-up similar to that of Malays, Chinese and Indians in Singapore, environmental factors may contribute to the higher myopia rates.


Asunto(s)
Errores de Refracción/etnología , Pueblo Asiatico/estadística & datos numéricos , Astigmatismo/etnología , Niño , Escolaridad , Femenino , Humanos , Hiperopía/etnología , Malasia/epidemiología , Masculino , Miopía/etnología , Prevalencia , Singapur/epidemiología , Población Blanca/estadística & datos numéricos
20.
Br J Ophthalmol ; 90(6): 769-72, 2006 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-16488932

RESUMEN

BACKGROUND: Pterygium is a fibrovascular overgrowth from the conjunctiva onto the cornea. The pathogenesis of this common ocular surface disorder is not well understood and the only treatment is surgical removal. METHODS: DNA microarray analysis of primary pterygium tissue was carried out using uninvolved conjunctiva tissue as a comparison for gene expression levels. Real time polymerase chain reaction (PCR) was used to verify the mRNA level of expression for genes changed in pterygium. Western blot analysis and immunohistochemistry showed protein expression levels and the tissue distribution. RESULTS: Microarray analysis revealed that mRNA levels of a number of genes were changed in primary pterygium. In particular the gene for insulin-like growth factor binding protein-3, (IGFBP3), which modulates the effects of insulin-like growth factor on cells was significantly decreased. Both the message and protein expression of IGFBP3 in pterygium were decreased compared to normal, uninvolved conjunctiva. CONCLUSION: Decreased levels of IGFBP3 protein have been strongly correlated with the presence of cancer. Identification of the low level of expression of IGFBP3 in pterygium suggests that the pathway controlling cell proliferation has lost an important control mechanism, which may explain the continued growth of pterygium.


Asunto(s)
Proteína 3 de Unión a Factor de Crecimiento Similar a la Insulina/biosíntesis , Pterigion/metabolismo , Adulto , Western Blotting , Regulación hacia Abajo , Femenino , Humanos , Proteína 2 de Unión a Factor de Crecimiento Similar a la Insulina/biosíntesis , Proteína 2 de Unión a Factor de Crecimiento Similar a la Insulina/genética , Proteína 3 de Unión a Factor de Crecimiento Similar a la Insulina/genética , Masculino , Persona de Mediana Edad , Análisis de Secuencia por Matrices de Oligonucleótidos/métodos , Reacción en Cadena de la Polimerasa/métodos , ARN Mensajero/genética , Reacción en Cadena de la Polimerasa de Transcriptasa Inversa/métodos
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