RESUMEN
There is limited evidence linking airway inflammation and lung function impairment in older non-smoking asthmatics with fixed airflow obstruction (FAO), which can develop despite treatment with inhaled corticosteroids (ICS). We assessed lung function (spirometry, forced oscillation technique (FOT)), lung elastic recoil and airway inflammation using bronchoalveolar lavage (BAL) in non-smoking adult asthmatics with FAO, following 2 months treatment with high-dose ICS/long-acting beta-agonist. Subjects demonstrated moderate FAO, abnormal FOT indices and loss of lung elastic recoil. This cross-sectional study showed a lack of a relationship between BAL neutrophils, eosinophils, inflammatory cytokines and lung function impairment. Other inflammatory pathways or the effect of inflammation on lung function over time may explain FAO development.
Asunto(s)
Corticoesteroides/uso terapéutico , Asma/tratamiento farmacológico , Asma/fisiopatología , No Fumadores , Enfermedad Pulmonar Obstructiva Crónica/tratamiento farmacológico , Enfermedad Pulmonar Obstructiva Crónica/fisiopatología , Corticoesteroides/farmacología , Anciano , Asma/diagnóstico , Líquido del Lavado Bronquioalveolar , Estudios de Cohortes , Estudios Transversales , Femenino , Volumen Espiratorio Forzado/efectos de los fármacos , Volumen Espiratorio Forzado/fisiología , Humanos , Inflamación/diagnóstico , Inflamación/tratamiento farmacológico , Inflamación/fisiopatología , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Enfermedad Pulmonar Obstructiva Crónica/diagnóstico , Pruebas de Función Respiratoria/métodos , Espirometría/métodosRESUMEN
Naproxen sodium is a new non-steroid antiinflammatory drug. This paper reported the results of clinical trial of the drug in 229 cases of orthopedic conditions. Among them, 103 cases were observed with double method. The rate of symptomatic relief was 81.3% (75 cases) for rheumatoid arthritis, 72.4% (29 cases) for osteoarthritis, 76.5% (34 cases) for herniations of lumbar discs and 93% (91 cases) for mild post-operative pain. The overall efficacy of the drug was 84.2% with 6.1% side effects, chiefly gastric reactions.
