RESUMEN
The change in alpha-tocopherol content (as an index of the antioxidative organism system mobilization) in the brain, liver, muscles and heart of rats prior to and after total gamma-irradiation with lethal dose has been studied. Prior to the irradiation alpha-tocopheryl-acetate (oil solution), alpha-tocopheryl-phosphate dipotassium salt (water solution), gammaphos (prepared WR 2721, water solution) were introduced into rats. It is shown that water-soluble form of vitamin E is more effective than gammaphos and much more efficient than oil form of alpha-tocopherol.
Asunto(s)
Amifostina/uso terapéutico , Traumatismos Experimentales por Radiación/prevención & control , Protectores contra Radiación/uso terapéutico , Vitamina E/análogos & derivados , Irradiación Corporal Total , alfa-Tocoferol/análogos & derivados , Amifostina/farmacología , Animales , Encéfalo/efectos de los fármacos , Encéfalo/efectos de la radiación , Corazón/efectos de los fármacos , Corazón/efectos de la radiación , Hígado/efectos de los fármacos , Hígado/efectos de la radiación , Músculos/efectos de los fármacos , Músculos/efectos de la radiación , Protectores contra Radiación/farmacología , Ratas , Ratas Wistar , Soluciones , Tocoferoles , Vitamina E/farmacología , Vitamina E/uso terapéuticoRESUMEN
The content of alpha-tocopherol in brain, liver, heart and muscle of Wistar rats has been studied. The water-soluble form of alpha-tocopherol: alpha-tocopheryl-phosphate dipotassium is more effective than the oil-soluble form: alpha-tocopheryl-acetate.