[Experimental ethanol poisoning in rats]. / Unele aspecte în intoxicatia experimentala cu etanol la sobolan.

Ethanol is one of the most used substances that produce liver lesions. The differences between species, the pathway of administration and the genetic variation are factors that influence the response of liver to ethanol. The experiment used adult male Wistar rats and the hepatic lesions were assessed using standard histological examination. The results show an increase of triglycerides in liver cells even in acute intoxication, the most affected cells being located in the periphery of the hepatic lobule, associated with a dilatation of blood vessels.

[Pharmacological studies of sulbactam and its association with semisynthetic beta-lactam antibiotics]. / Cercetari farmacologice asupra sulbactamei si asocierii sale cu unele antibiotice beta-lactamice de semisinteza.

The acute toxicity, local tolerance and pharmacokinetic properties of sulbactame manufactured by the Iasi Antibiotic Investigation Centre, alone or in association with ampicillin or amoxicillin were tested. Some tests were made comparatively with the product Unasyn--Pfizer. The obtained data show that this beta-lactamase inhibitor has a low toxicity--DL50 i.p. in mice over 4,000 mg/kg, both alone or associated with the two semisynthetic beta-lactamic antibiotics. The local tolerance is good and the serum levels of the above mentioned associations are above towards the tested bacteria and are similar or very close to those of Unasyn. It is believed that the therapeutical use of the association sulbactame + ampicillin or sulbactame + amoxicillin is very useful in the beta-lactamase producing germs infection.

[The evaluation of the teratogenesis and embryotoxicity of the pharmaceutical product Boicil tablets. I. The effect of the pharmaceutical product Boicil tablets on fertilization and implantation in rats and mice]. / Evaluarea teratogenezei si embriotoxicitatii la produsul farmaceutic Boicil-comprimate. Nota I: Efectul produsului farmaceutic Boicil-comprimate asupra fertilizarii si implantarii la sobolani si soareci.

The teratogen action of Boicil tablets was studied in two animal species, rats and mice, the prefertilization and implantation stages being the main interest. Three generations of animals were followed up. The active powder suspended in distilled water (0.1 ml/10 g for mice and 1 ml/100 g for rats) was administered per os in a single dose, prepared on spot and in two doses, 2 mg/kg body weight and 20 mg kg body weight, respectively. The administered doses were equivalent to the daily maximum therapeutic dose prescribed in humans (110 mg active principle). The first gestational day was determined differently in the two species. For estimating the effect on prefertilization, Boicil tablets was administered for 5 days before making and for its effects on the number of implantations during the first 3 gestational days. The two parameters under investigation were within normal limits and all newborn animals followed up for three generations did not present pathological microscopic and gross alterations or somatic malformations. It was concluded that Boicil tablets is not teratogenic.