RESUMEN
Influenza viruses A/Philippines/341/2004 (H1N2) and A/Thailand/271/2005 (H1N1) were isolated from two males, with mild influenza providing evidence of sporadic human infection by contemporary swine influenza. Both viruses were antigenically and genetically distinct from influenza A (H1N1 and H1N2) viruses that have circulated in the human population. Genetic analysis of the haemagglutinin genes found these viruses to have the highest degree of similarity to the classical swine H1 viruses circulating in Asia and North America. The neuraminidase gene and the internal genes were found to be more closely related to viruses circulating in European swine, which appear to have undergone multiple reassorting events. Although transmission of swine influenza to humans appears to be a relatively rare event, swine have been proposed as the intermediate host in the generation of potential pandemic influenza virus that may have the capacity to cause human epidemics resulting in high morbidity and mortality.
Asunto(s)
Subtipo H1N1 del Virus de la Influenza A/genética , Gripe Humana/virología , Porcinos/virología , Adulto , Animales , Preescolar , Humanos , Gripe Humana/epidemiología , Masculino , Datos de Secuencia Molecular , Filipinas/epidemiología , Filogenia , Virus Reordenados/genética , Tailandia/epidemiologíaRESUMEN
An outbreak of Influenza A virus occurred in a hilltribe village between July 18th and August 8th, 1997. The overall infection rate was 92.5 per cent. The household infection rate was higher in the crowded part of the village. The symptoms analyzed after all, were fever (100%), cough (99%), headache, myalgia (78.1%) and rhinorrhea (50.5%). The patients were self - recovery within 5-7 days. Isolation and Haemagglutination inhibition test (HI) were undertaken to identify the causative agent. The results were positive for influenza A/Wuhan/359/95(H3N2) - like strain. The outbreak did not spread to the town, possibly because of the differences in environmental condition. Predisposing factors of the village that may have influenced the outbreak were crowded living quarters, cold (8 - 10 degrees C) and moist weather, poor personal hygiene and improper sanitation.
Asunto(s)
Brotes de Enfermedades , Virus de la Influenza A , Gripe Humana/epidemiología , Femenino , Humanos , Gripe Humana/diagnóstico , Masculino , Población Rural , Tailandia/epidemiologíaRESUMEN
A prospective study was conducted to find the incidence and clinical manifestations of influenza in 201 nurse assistant students of Faculty of Tropical Medicine during June 1998 to May 1999. There were 106 episodes of influenza-like illness (incidence 52.7%) of which only 33% were proven to be influenza (incidence 17.4%). Main clinical manifestations of influenza included headache, fever, malaise, myalgia, rhinorrhea, cough, and sore throat. We found that influenza could not be diagnosed solely by using clinical manifestations. Respiratory pathogenic bacteria were rarely isolated in patients with influenza-like illness and this led to our suggestion that routine pharyngeal culture and antibiotic therapy would not be helpful. Influenza vaccination of every nurse assistant student would be beneficial.
