1.
Bioorg Med Chem Lett
; 17(15): 4347-50, 2007 Aug 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-17531480
RESUMEN
High throughput screening identified a phenoxyacetic acid scaffold as a novel CRTh2 receptor antagonist chemotype, which could be optimised to furnish a compound with functional potency for inhibition of human eosinophil shape change and oral bioavailability in the rat.