[Depression in patients with chronic hepatitis C during the antiviral treatment: a clinical and psychopathological qualification and a nosological interpretation].

Authors studied 160 patients with chronic hepatitis C on antiviral treatment. Depressive disorders developed in 85 patients. Clinical and pharmacotherapeutic features of depression were specified. Predictors for the prevalence, structure and severity of the depressive syndrome were found. The clinical and demographic heterogeneity of depressions was identified. The results of the clinical and statistical analysis allow to specify the nosological qualification of these depressions, to optimize diagnostic and treatment algorithms and to make more effective treatment of the main disease (chronic hepatitis C).

[Depressive disturbances during antiviral therapy in patients with type C hepatitis].

The article presents the results of a clinico-psychopathological study of depressive disorder (DD) in 91 patients with chronic C hepatitis and no psychiatric background during combined antiviral therapy (AVT) with interferon-alpha (IFN-alpha) and ribavirin. Depression developed in 39 or 43% of the patients. Moderate or severe depressions (46% and 31%, respectively) prevailed. Clinical features that were different in cases of IFNa-induced depression and endogenous DD were revealed. The severity of depression did not correlate with the severity of the underlying disease, the duration of AVT, and the type of used. The antidepressants and remeron proved to be effective in treatment of IFN-alpha-induced depressions. In all cases, treatment with antidepressants made it possible to carry out complete AVT.