[Data on the hygienic regulation of benzanthrone-based vat dyes in the air of a work area]. / Materialy k gigienicheskoi reglamentatsii kubozolei na osnove benzantrona v vozdukhe rabochei zony.

With regard to acute toxicity, the cubosols are attributed to the non-cumulative compounds of low toxicity. Acute inhalation exposure threshold for cubosol "Bright green" is over 140 mg/m3. Subacute poisonings developed following intragastric administrations in concentrations 1 g/kg for 30 days, and were characterized by polymorphism of the signs. Revealed were delayed body mass increment in the laboratory animals, changes in peripheral blood and hepatorenal morphology and function.

Potential-dependent Ca channels of neurons in the mollusc Lymnaea stagnalis in aging: effect of norepinephrine.

During aging changes occur in the function of potential-dependent Ca channels of plasmic membrane of identified neurons in the mollusc Lymnaea stagnalis, i.e. the value of Ca inward current of neurons in old vs. adult molluscs was much higher at holding potential -50 - -30 mV. When held at -20 mV, the amplitude of Ca current decreased in the neurons of old molluscs, but continued to increase in those of adult molluscs. Various populations of potential-dependent Ca channels are assumed to have irregular age-related changes. The norepinephrine-induced inhibition of Ca current was more significant in old vs. adult molluscan neurons.

[Potential-dependent calcium channels of neurons of mollusks of various ages]. / Potentsialzavisimye kal'tsievye kanaly neironov molliuskov raznogo vozrasta.

It is shown that with the holding potentials (Eh) ranging from -50 to -30 mV the amplitudes of the inward Ca current of identified neurons are significantly higher in old (20-24 months) Lymnaea stagnalis molluscs than in adult ones.

[Hygienic aspects of working conditions of women engaged in the processing of synthetic dyes and semi-products]. / Gigienicheskie aspekty zhenskogo truda v proizvodstvakh sinteticheskikhkrasitelei i poluproduktov.

Unfavourable labour conditions were traced among female workers engaged in the production of aromatic carbohydrate-based synthetic dyes and intermediates. The professional group was marked by increased occupational morbidity with temporary disability and complicated pregnancies with unfavourable terminations. Limitations were proposed in the employment of female workers of reproductive age in this branch of industry, particularly for those dealing with the substances of 1-2 degree of hazard referred to the nitroaminochlorine-derivative benzene group.

Age-related changes in the function of somatic membrane potassium channels of neurons in the mollusc Lymnaea stagnalis.

The function of the membrane potassium channels of the identified neurons of the small parietal ganglion was investigated in the adult (10-12-month) and old (22-24-month) molluscs Lymnaea stagnalis. Old molluscan neurons showed a decrease in maximal amplitude of fast and delayed potassium currents, in maximal potassium conductance, and in kinetics of inactivation of the delayed outward current. These features may be conditioned by the age changes in phospholipid composition of the membranes, rather than by the shifts of neuronal surface area during aging. Age dynamics in the function of potassium channels is thought to cause changes in the neuronal function.

[Functional characteristics of potassium channels in the somatic membrane of neurons of Lymnaea stagnalis of various ages]. / Funktsional'nye kharakteristiki kalievykh kanalov somaticheskoi membrany neironov prudovikov raznogo vozrasta.

It has been found that in old Lymnaea stagnalis neurons the maximal amplitude of the delayed potassium current and the maximal potassium conductance decreases and the kinetics of inactivation of the delayed outward current slows down. It is suggested that these changes may be associated with the age peculiarities of the phospholipid composition of membranes and not related to shifts in the surface area of the nerve cell during aging. The age dependence of the function of potassium channels may underlie the changes in the neuronal function during aging.

[Role of protein biosynthesis activation in the mechanism of the negative chronotropic action of the vagus nerve and acetylcholine on the heart]. / Rol'aktivatsii biosinteza belka v mekhanizme otritsatel'nogo khronotropnogo deistviia bluzhdaiushchego nerva i atsetilkholina na serdtse.

In rats, the following data were obtained: a) acetylcholine activates the rate of protein biosynthesis in auricles in vitro; b) protein biosynthesis inhibitors (actinomycine D, sarcolysine, neutral rot, tolluidine blue) weaken the negative chronotropic effect of acetylcholine and vagus on the heart; c) anabolic hormones increase the cholinergic effect on heart; d) acetylcholine induces hyperpolarization of the myocardial fibers which is prevented by actinomycine D. The activation of protein biosynthesis followed by hyperpolarization of the pacemaker cells seems to play an important role in the mechanism of negative chronotropic effect of acetylcholine and vagus on the heart.