RESUMEN
Frequent reproductive casualties (spontaneous abortions, stillbirths, prematurity and low birth weight, congenital malformations) were recorded in a group of 264 women who had viral hepatitis (VH) during pregnancy. The proportion of such events was much higher in the HBsAg-positive women (80%) than in the seronegative ones (44%) and it varied according to the trimester when VH had occurred. Liver disease could be incriminated as the main cause of infant death in 20 out of 2110 cases investigated; 6 of the 20 mothers proved to be HBsAg-positive. Asymptomatic HBsAg carriage in a group of 3800 pregnant women was found to be of about 8%; the prevalence of HBsAg was higher in the subgroups of women with an unfavourable pregnancy evolution.
Asunto(s)
Anomalías Congénitas/etiología , Hepatitis B/complicaciones , Complicaciones Infecciosas del Embarazo , Aborto Espontáneo/etiología , Femenino , Muerte Fetal/etiología , Antígenos de Superficie de la Hepatitis B/análisis , Humanos , Recién Nacido de Bajo Peso , Recién Nacido , Hepatopatías/congénito , Trabajo de Parto Prematuro/etiología , Embarazo , Primer Trimestre del Embarazo , Segundo Trimestre del Embarazo , Tercer Trimestre del EmbarazoRESUMEN
Prospective and retrospective statistical studies were performed in 1,000 cases of congenital malformations. The incidences and severity of the different types of malformations were correlated with the risk and protection factors having acted on the pregnant woman. The correlation coefficients were higher in the case of specific risk factors, among which special attention was paid to maternal virus infections. The possibility is discussed of developing a programme for the individual protection of high-risk cases, implying the compensation of the exposure to risk factors by the application of adequate protection factors, according to the calculated scores.
