[Advantages of glucagon-like peptide-1 receptor agonists in the treatment of patients with type 2 diabetes mellitus: A review].

Glucagon-like peptide-1 receptor agonists (arGLP1) are an effective treatment for patients with type 2 diabetes mellitus (T2DM), mainly due to increasing insulin secretion and suppressing glucagon release by stimulating the respective receptors. Taking into account their positive effect on major cardiovascular events, drugs in this group with proven cardioprotective effects are recommended for patients with T2DM and clinical cardiovascular diseases or multiple cardiovascular risk factors. In this paper, we present an overview of current clinical studies on the clinical efficacy and safety of arGLP1 and discuss current prospects for arGLP1 as a therapy for patients with T2DM.

[Insulin therapy is a personalized approach to glycemic management in diabetes].

Type 2 diabetes is characterized by chronic hyperglycemia and varying degrees of insulin resistance and insulinopenia. Achieving targeted glycemic control in diabetic patients is important to reduce the risk of late complications, and many patients with type 2 diabetes ultimately require insulin therapy to maintain adequate glycemic control. Timely administration of insulin can prevent the progression of diabetes, reduce the development of complications, and have fewer side effects. Basal insulin is the preferred option in most cases when glycemic control is not achieved. However, there is considerable therapeutic inertia in clinical practice, both with respect to initiation of insulin therapy and titration of the basal insulin dose. The longer duration of action, reduced glucose variability and a lower risk of hypoglycemia seen with the latest generation of basal insulin analogs compared to the previous generation simplify titration and may increase patient compliance.

[Features of maternal behavior in women with epilepsy]. / Osobennosti materinskogo povedeniia bol'nykh épilepsiei zhenshchin.

AIM: To study characteristics of maternal behavior in women with epilepsy. MATERIAL AND METHODS: Twenty-three women with epilepsy, aged 25-35 years, with one or more children, aged 0-10 years, were interviewed. Thirty age-matched women were included in the control group. The following psychological methods were used: the projective test 'Mother and Child', the Scale of the degree of rejection of a child in the family, the Parent Institution Study Test Questionnaire (PARI), the projective methodology 'Unfinished sentences', a method for diagnosing the level of empathic abilities. RESULTS AND CONCLUSION: The style of child upbringing in women with epilepsy is authoritarian, directive. Often there is egocentrism, fixation on one's own behalf, internal coldness. Mothers with epilepsy have a reduced level of empathy and are irritable, anxious, hyperopic, indulgent, emotionally cold, hypochondriac, uncritical, dependent, devout, conceited.