1.
Neuromuscul Disord
; 15(11): 802-16, 2005 Nov.
Artículo
en Inglés
| MEDLINE
| ID: mdl-16202598
2.
Nucleic Acids Res
; 27(19): e27, 1999 Oct 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-10481039
RESUMEN
Spatially and temporally regulated somatic mutations can be achieved by using the Cre/LoxP recombination system of bacteriophage P1. In order to develop gene knockouts restricted to striated muscle, we generated a transgenic mouse line expressing Cre recombinase under the control of the human alpha-skeletal actin promoter. Specific excision of a loxP-flanked gene was demonstrated in striated muscle, heart and skeletal muscle, in a pattern very similar to the expression of the endogenous alpha-skeletal actin gene. Therefore, the reported transgenic line can be used to target inactivation or activation of a given gene to the skeletal muscle lineage.