1.
Neurology
; 91(18): 837-839, 2018 10 30.
Artículo
en Inglés
| MEDLINE
| ID: mdl-30258026
2.
Epilepsy Behav Case Rep
; 6: 67-9, 2016.
Artículo
en Inglés
| MEDLINE
| ID: mdl-27668180
RESUMEN
West Syndrome is characterized by infantile spasms, a hypsarrhythmic electroencephalogram (EEG) pattern, and a poor neurodevelopmental prognosis. First-line treatments include adrenocorticotrophic hormone (ACTH) and vigabatrin, but adverse effects often limit their use. CPP-115 is a high-affinity vigabatrin analogue developed to increase therapeutic potency and to limit retinal toxicity. Here, we present a child treated with CPP-115 through an investigational new drug protocol who experienced a marked reduction of seizures with no evidence of retinal dysfunction. Given the potential consequences of ongoing infantile spasms and the limitations of available treatments, further assessment of CPP-115 is warranted.