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1.
F1000Res ; 3: 4, 2014.
Artículo en Inglés | MEDLINE | ID: mdl-24715973

RESUMEN

Melioidosis is endemic in areas of Southeast Asia, however, there are no published reports from the Thai-Myanmar border. We report the first two documented cases of fatal melioidosis in this region. This is of great public health importance and highlights the need to both increase clinical awareness of melioidosis on the Thai-Myanmar border, and to assess the true burden of disease in the area through improved case detection and Burkholderia pseudomallei prevalence studies.

2.
Curr Opin Immunol ; 22(1): 55-62, 2010 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-20137905

RESUMEN

While inflammatory phagocytosis of microbial pathogens and non-inflammatory phagocytosis of apoptotic cells have each been studied extensively, the consequences of innate immune recognition of host cells undergoing apoptosis as a direct result of infection are unclear. In this situation, the innate immune system is confronted with mixed signals, those from apoptotic cells and those from the infecting pathogen. Nuclear receptor activation has been implicated downstream of apoptotic cell recognition while Toll-like receptors are the prototypical inflammatory receptors engaged during infection. When the two signals combine, a new set of events takes place beginning with transrepression of a subset of inflammatory-response genes and ending with the induction of a T helper-17 adaptive immune response. This response is best suited for clearing the infecting pathogen and repairing the damage that occurred to the host tissue during infection.


Asunto(s)
Apoptosis , Infecciones/inmunología , Mediadores de Inflamación/inmunología , Inmunidad Adaptativa , Animales , Humanos , Infecciones/metabolismo , Infecciones/patología , Mediadores de Inflamación/metabolismo , Receptores Toll-Like/inmunología , Receptores Toll-Like/metabolismo
3.
Cell Mol Life Sci ; 67(9): 1407-21, 2010 May.
Artículo en Inglés | MEDLINE | ID: mdl-20054607

RESUMEN

In the few years since their discovery, T helper 17 cells (T(H)17) have been shown to play an important role in host defense against infections, and in tissue inflammation during autoimmunity. T(H)17 cells produce IL-17, IL-21, IL-10, and IL-22 cytokines, and thus have broad effects on a variety of tissues. Notably, the requirement for the immunosuppressive cytokine TGF-beta along with the pro-inflammatory cytokine IL-6 for T(H)17 differentiation supports the intimate relationship between the T(H)17 subset and FOXP3(+) regulatory T cells. Here, we discuss current knowledge on effector functions and differentiation of the T(H)17 lineage. Furthermore, we now know of a physiological stimulus for T(H)17 differentiation: innate immune recognition of cells undergoing apoptosis as a direct result of infection induces unique development of this subset. As our knowledge of T(H)17 and T regulatory cells grows, we are building on a new framework for the understanding of effector T cell differentiation and the biology of CD4(+) T cell adaptive immune responses.


Asunto(s)
Interleucina-17/inmunología , Subgrupos de Linfocitos T/inmunología , Linfocitos T Colaboradores-Inductores/inmunología , Animales , Autoinmunidad/inmunología , Linfocitos T CD4-Positivos/inmunología , Diferenciación Celular/inmunología , Citocinas/inmunología , Células Dendríticas/inmunología , Humanos , Inmunidad Innata/inmunología , Inflamación/inmunología , Interleucina-10/inmunología , Interleucinas/inmunología , Receptores de Antígenos de Linfocitos T/inmunología , Factor de Transcripción STAT3/inmunología , Transducción de Señal/inmunología , Subgrupos de Linfocitos T/citología , Linfocitos T Colaboradores-Inductores/citología , Linfocitos T Reguladores/inmunología , Interleucina-22
4.
Nature ; 458(7234): 78-82, 2009 Mar 05.
Artículo en Inglés | MEDLINE | ID: mdl-19262671

RESUMEN

Adaptive immune responses rely on differentiation of CD4 T helper cells into subsets with distinct effector functions best suited for host defence against the invading pathogen. Interleukin (IL)-17-producing T helper cells (T(H)17) are a recently identified subset, separate from the T helper type 1 (T(H)1) and T helper type 2 (T(H)2) subsets. Synergy between the cytokines transforming growth factor-beta and IL-6 in vitro induces development of T(H)17 cells in mouse and human systems, whereas IL-23 supports expansion of these cells. However, it is not known which conditions in vivo would induce this combination of cytokines. Furthermore, it is enigmatic that a combination of pro-inflammatory and anti-inflammatory cytokines would be required to generate an effector T(H)17 response. Here we show that the relevant physiological stimulus triggering this combination of cytokines is the recognition and phagocytosis of infected apoptotic cells by dendritic cells. Phagocytosis of infected apoptotic cells uniquely triggers the combination of IL-6 and transforming growth factor-beta through recognition of pathogen-associated molecular patterns and phosphatidylserine exposed on apoptotic cells, respectively. Conversely, phagocytosis of apoptotic cells in the absence of microbial signals induces differentiation of the closely related regulatory T cells, which are important for controlling autoimmunity. Blocking apoptosis during infection of the mouse intestinal epithelium with the rodent pathogen Citrobacter rodentium, which models human infections with the attaching and effacing enteropathogenic and enterohaemorrhagic Escherichia coli, impairs the characteristic T(H)17 response in the lamina propria. Our results demonstrate that infected apoptotic cells are a critical component of the innate immune signals instructing T(H)17 differentiation, and point to pathogens particularly adept at triggering apoptosis that might preferentially induce T(H)17-mediated immunity. Because T(H)17 cells have been correlated with autoimmune diseases, investigation of the pathways of innate recognition of infected apoptotic cells might lead to improved understanding of the causative defects in autoimmunity.


Asunto(s)
Apoptosis , Diferenciación Celular , Citrobacter rodentium/inmunología , Inmunidad Innata/inmunología , Interleucina-17/inmunología , Linfocitos T Colaboradores-Inductores/citología , Linfocitos T Colaboradores-Inductores/inmunología , Animales , Citrobacter rodentium/fisiología , Células Dendríticas/inmunología , Células Dendríticas/metabolismo , Interleucina-10/biosíntesis , Interleucina-10/inmunología , Interleucina-17/metabolismo , Interleucina-23/inmunología , Interleucina-6/biosíntesis , Ligandos , Ratones , Ratones Endogámicos C57BL , Fagocitosis , Linfocitos T Colaboradores-Inductores/metabolismo , Receptores Toll-Like/inmunología , Receptores Toll-Like/metabolismo , Factor de Crecimiento Transformador beta/inmunología
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