Asunto(s)
Trasplante de Riñón , Ácido Micofenólico , China , Humanos , Terapia de Inmunosupresión , Estudios RetrospectivosRESUMEN
This response refutes the claim made in a recent article that organs for transplantation in China will no longer be sourced from executed prisoners. We identify ongoing ethical problems due to the lack of transparent data on current numbers of transplants in China; implausible and conflicting claims about voluntary donations; and obfuscation about who counts as a voluntary donor. The big unanswered question in Chinese transplant ethics is the source of organs, and until there is an open and independently audited system in China, legitimate concerns remain about organ harvesting from prisoners of conscience.
Asunto(s)
Pena de Muerte/legislación & jurisprudencia , Ética Médica , Trasplante de Órganos/ética , Prisioneros , Obtención de Tejidos y Órganos , China/epidemiología , Coerción , Comercio , Humanos , Consentimiento Informado/legislación & jurisprudencia , Trasplante de Órganos/legislación & jurisprudencia , Consentimiento Presumido/legislación & jurisprudencia , Obtención de Tejidos y Órganos/ética , Obtención de Tejidos y Órganos/legislación & jurisprudenciaRESUMEN
In this text, we present and elaborate ethical challenges in transplant medicine related to organ procurement and organ distribution, together with measures to solve such challenges. Based on internationally acknowledged ethical standards, we looked at cases of organ procurement and distribution practices that deviated from such ethical standards. One form of organ procurement is known as commercial organ trafficking, while in China the organ procurement is mostly based on executing prisoners, including killing of detained Falun Gong practitioners for their organs. Efforts from within the medical community as well as from governments have contributed to provide solutions to uphold ethical standards in medicine. The medical profession has the responsibility to actively promote ethical guidelines in medicine to prevent a decay of ethical standards and to ensure best medical practices.
Asunto(s)
Ética Médica , Trasplante de Órganos/ética , Recolección de Tejidos y Órganos/ética , Obtención de Tejidos y Órganos/ética , China , Humanos , Principios Morales , PrisionerosRESUMEN
AIMS: It has recently been proposed that anaemia is an independent risk factor for development of cardiovascular disease in the general population. The impact of anaemia on long-term survival of patients with manifest coronary heart disease (CHD) has not been assessed so far. In this study, we examined the influence of haemoglobin concentrations on the outcome after percutaneous coronary interventions (PCI). METHODS AND RESULTS: In a retrospective cohort study, we analysed in-hospital and long-term mortality in all male patients admitted to our institution for elective PCI from 1998 to 1999. In 689 cases, complete follow-up information could be obtained (98.4%). Depending on their baseline haemoglobin, patients were divided in quintiles. In all subgroups, angiographic success after PCI (90-94%) was comparably high and in-hospital mortality was low (0-0.7%). During follow-up (median 697 days), patients in the lowest haemoglobin quintile (=12.9g/dl) were significantly more likely to suffer from all-cause death (22.2%) than those of the other quintiles (3.7-12.1%; estimated mortality rates from Kaplan-Meier models, P<0.0001, log rank test). In more detail, we found a U-shaped relationship between mortality and haemoglobin strata in steps of 1g/dl (P<0.0001, log rank test). After adjustment for potential co-variates, patients of the lowest haemoglobin quintile showed in Cox regression analysis a markedly higher risk for death (adjusted hazard rate ratio (HRR) 4.09, 95% confidence interval (CI) 1.52-11.05) compared to the quintile with a haemoglobin concentration of 14.6-15.2g/dl. CONCLUSIONS: These results indicate that anaemia is associated with markedly reduced survival in patients with CHD after elective PCI. Since PCI is a common intervention and anaemia is a frequent condition in the general population, strategies for the management of anaemic PCI patients and treatment of anaemic patients with CHD should be developed.
Asunto(s)
Anemia/mortalidad , Angioplastia Coronaria con Balón/mortalidad , Enfermedad Coronaria/terapia , Hemoglobinas/análisis , Análisis de Varianza , Anemia/sangre , Anemia/etiología , Causas de Muerte , Estudios de Cohortes , Enfermedad Coronaria/sangre , Enfermedad Coronaria/mortalidad , Estudios de Seguimiento , Mortalidad Hospitalaria , Humanos , Masculino , Estudios Retrospectivos , Factores de Riesgo , Análisis de Supervivencia , Texas/epidemiologíaRESUMEN
BACKGROUND: Patients with moderate chronic renal failure have recently been identified to suffer from a markedly higher mortality after percutaneous coronary intervention (PCI). We focused on the outcome of PCI patients with just mildly elevated creatinine levels of 1.1 to 1.5 mg/dL. METHODS: Data of all PCI patients of the years 1998 to 1999 were analyzed. Follow-up was performed by a questionnaire sent to all patients. RESULTS: During this period, PCI was performed in 1049 patients. Long-term follow-up (1184 +/- 10 days) was 99.6% complete. Total mortality increased continuously by each creatinine increment of 0.1 mg/dL above 1.0 mg/dL, with a significant difference at 1.3 mg/dL compared to patients with Asunto(s)
Angioplastia Coronaria con Balón
, Enfermedad Coronaria/complicaciones
, Enfermedad Coronaria/terapia
, Fallo Renal Crónico/complicaciones
, Fallo Renal Crónico/mortalidad
, Fallo Renal Crónico/fisiopatología
, Anciano
, Área Bajo la Curva
, Creatinina/sangre
, Estudios Transversales
, Femenino
, Estudios de Seguimiento
, Humanos
, Fallo Renal Crónico/sangre
, Masculino
, Persona de Mediana Edad
, Análisis Multivariante
, Curva ROC
, Estudios Retrospectivos
, Resultado del Tratamiento