RESUMEN
The aim of the study was to raise efficacy of combined treatment of stage II Hodgkin's disease by optimization of fractionation and volume of irradiation. It included 179 patients with involvement of supradiaphragmatic lymph nodes treated in 1986-2006. It was found that multi-fractionation was followed by lower frequency of relapse as compared with standard regimens as well as rates of early ones. The most efficient dosage was 30-36 Gy as far as frequency, term of relapse occurrence and recurrence-free survival were concerned.
Asunto(s)
Enfermedad de Hodgkin/patología , Enfermedad de Hodgkin/terapia , Adolescente , Adulto , Anciano , Supervivencia sin Enfermedad , Fraccionamiento de la Dosis de Radiación , Femenino , Enfermedad de Hodgkin/mortalidad , Enfermedad de Hodgkin/radioterapia , Humanos , Masculino , Persona de Mediana Edad , Estadificación de Neoplasias , Dosificación Radioterapéutica , Radioterapia Adyuvante , Recurrencia , Estudios Retrospectivos , Análisis de Supervivencia , Factores de Tiempo , Resultado del Tratamiento , Adulto JovenRESUMEN
Clinical efficacy of combined treatment of 383 patients who had undergone conservative surgery for extremity soft-tissue sarcomas (combined treatment -188; surgery alone - 195, control) was assessed. The comparison, which included prognostic factors, established the advantages of combined treatment in all groups. Thus, overall 5-year survival time was in 64.3+/-2.8%, with combined treatment - 72.2+/-3.3% and surgery - 56.8+/-3.5%, t>2. Application of radiotherapy as a component of combined modality treatment made feasible a wider range of organ-saving operations. Differences in the frequency of postoperative complications after surgery and combined treatment were insignificant and of similar patterns.
Asunto(s)
Sarcoma/terapia , Neoplasias de los Tejidos Blandos/terapia , Terapia Combinada , Humanos , Sarcoma/radioterapia , Sarcoma/cirugía , Neoplasias de los Tejidos Blandos/radioterapia , Neoplasias de los Tejidos Blandos/cirugía , Análisis de SupervivenciaRESUMEN
In an analysis of data of 526 patients with carcomas of the extremity soft tissues the factors influencing the decision on the volume of surgery were determine. The 5 year survival of patients subjected to amputations was considerably lower than after sparing operations. Amputations were mostly made for local recurrences of the disease, neoplasm larger than 15 cm in diameter, low-differentiated sarcomas, with infiltration of the tumor into the bone and/or periosteum and localization of the tumor in distal parts of extremities. The rates of 5 year survival among the patients with malignant tumors of the extremity soft tissues subjected to sparing operations were found to be higher after combined program of treatment (operation + radiation therapy).
Asunto(s)
Brazo , Pierna , Sarcoma/cirugía , Procedimientos Quirúrgicos Operativos/métodos , Adolescente , Adulto , Toma de Decisiones , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Sarcoma/patología , Índice de Severidad de la EnfermedadRESUMEN
An analysis of results of treatment and prostheses of 89 patients with malignant tumors of the upper extremities and shoulder girdle has shown that among the tumors there were osteogenous sarcomas, chondroid sarcomas, nonclassified sarcomas, reticulosarcomas, angiosarcoma, fibrohistocytic sarcoma, Euring's sarcoma, solitary myeloma, giant cells tumors. Interscapular-thoracic amputations were performed in all the patients. The overall survival rate was (28.6 +/- 8.3)%. An orthosis and a modified prosthesis developed at the research institute of prostheses named after prof. G. Albrekht are recommended for rehabilitation of invalids.
