Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 105
Filtrar
1.
Neuroscience ; 305: 238-47, 2015 Oct 01.
Artículo en Inglés | MEDLINE | ID: mdl-26241340

RESUMEN

Acidic fibroblast growth factor (aFGF) is a neurotrophic factor which is a powerful neuroprotective and neuroregenerative factor of the nervous system. Prior study had shown that levels of FGFs significantly increase following ischemic injury, reflecting a physiological protection mechanism. However, few reports demonstrated the efficacy of applying aFGF in cerebral ischemia. A recent report showed that the intranasal aFGF treatment improved neurological functional recovery; however, it did not significantly reduce the lesion size in ischemic rats. The present study examines the neuroprotective effect of aFGF on cortical neuron-glial cultures under oxygen glucose deprivation (OGD)-induced cell damage and investigates whether epidural application of slow-released aFGF could improve benefit on ischemic stroke injury in conscious rats. We used a topical application of aFGF mixed in fibrin glue, a slow-release carrier, over the peri-ischemic cortex and examined such treatment on cerebral infarction and behavioral impairments of rats subjected to focal cerebral ischemia (FCI). Results demonstrate that aFGF effectively protected cortical neuron-glial cultures from OGD-induced neuronal damage. Neurite extension from cortical neurons was significantly enhanced by aFGF, mediated through activation of AKT and ERK. In addition, topical application of fibrin glue-mixed aFGF dose-dependently reduced ischemia-induced brain infarction and improved functional restoration in ischemic stroke rats. Slow-released aFGF not only protected hippocampal and cortical cell loss but reduced microglial infiltration in FCI rats. Our results suggest that aFGF mixed in fibrin glue could prolong the protective/regenerative efficacy of aFGF to the damaged brain tissue and thus improve the functional restorative effect of aFGF.


Asunto(s)
Factor 1 de Crecimiento de Fibroblastos/uso terapéutico , Infarto de la Arteria Cerebral Media/patología , Neuritas/efectos de los fármacos , Neuronas/efectos de los fármacos , Neuronas/patología , Fármacos Neuroprotectores/uso terapéutico , Animales , Infarto Encefálico/inducido químicamente , Infarto Encefálico/tratamiento farmacológico , Hipoxia de la Célula/efectos de los fármacos , Células Cultivadas , Modelos Animales de Enfermedad , Embrión de Mamíferos , Factor 1 de Crecimiento de Fibroblastos/farmacología , Lateralidad Funcional , Glucosa/deficiencia , Infarto de la Arteria Cerebral Media/complicaciones , Infarto de la Arteria Cerebral Media/tratamiento farmacológico , MAP Quinasa Quinasa Quinasa 3/metabolismo , Masculino , Trastornos del Movimiento/tratamiento farmacológico , Trastornos del Movimiento/etiología , Neuroglía/efectos de los fármacos , Fármacos Neuroprotectores/farmacología , Proteínas Proto-Oncogénicas c-akt/metabolismo , Ratas , Ratas Long-Evans , Ratas Sprague-Dawley , Transducción de Señal/efectos de los fármacos
2.
Opt Lett ; 34(18): 2733-5, 2009 Sep 15.
Artículo en Inglés | MEDLINE | ID: mdl-19756087

RESUMEN

We demonstrate a chip-scale compact optical curvature sensor. It consists of a low threshold InGaAsP microdisk laser on a flexible polydimethylsiloxane polymer substrate. The curvature dependence of lasing wavelength was characterized by bending the cavity at different bending radii. The measurements showed that the lasing wavelength decreases monotonously with an increasing bending curvature. A good agreement between experiment and three-dimensional finite-difference time-domain simulation was also obtained. The sensitivity of the compact device to the bending curvature is -23.7 nm/mm from the experiment.

3.
Opt Express ; 17(2): 991-6, 2009 Jan 19.
Artículo en Inglés | MEDLINE | ID: mdl-19158916

RESUMEN

Compact microdisk cavities were fabricated on a polydimethylsiloxane substrate. The lasing of the flexible compact cavity was achieved with a low threshold power. The whispering-gallery mode of the microdisk was also characterized with three-dimensional finite-difference time-domain simulation. The curvature dependence in output power and threshold was also demonstrated by bending the microdisk cavity.

4.
Int J Obstet Anesth ; 14(3): 252-5, 2005 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-15935643

RESUMEN

We present a rare case in which a healthy parturient developed a paraspinal abscess after spinal anaesthesia for caesarean section and epidural analgesia for postoperative pain management. The catheter was in situ for 58 h. Backache was the initial and major symptom. A concealed course with no neurological deficit resulted in a delayed diagnosis and treatment in this case. The infection was not diagnosed until 20 days after the removal of the epidural catheter when there was a purulent discharge from the epidural puncture site. Surgical drainage was required. Anaesthesiologists should be aware that serious epidural analgesia-related infections can happen in extra spinal-epidural spaces. Vigilance for these infections, especially in postpartum patients with backache, is needed.


Asunto(s)
Absceso/etiología , Analgesia Epidural , Analgesia Controlada por el Paciente , Anestesia Obstétrica , Anestesia Raquidea , Cesárea , Dolor Postoperatorio/tratamiento farmacológico , Absceso/patología , Adulto , Drenaje , Femenino , Humanos , Imagen por Resonancia Magnética , Dolor Postoperatorio/complicaciones , Embarazo
5.
Br J Anaesth ; 94(6): 856-8, 2005 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-15764626

RESUMEN

An 86-yr-old man with recurrent laryngeal carcinoma developed gastric rupture after awake fibreoptic intubation before induction of general anaesthesia. Early clinical signs included a distended, tense and tympanic abdomen with pain and massive pneumoperitoneum (chest radiograph). Laparotomy revealed a 4-cm longitudinal perforation along the lesser curvature of the stomach. This case represents a rare but severe complication that may occur during fibreoptic intubation in the awake patient.


Asunto(s)
Tecnología de Fibra Óptica , Complicaciones Intraoperatorias , Intubación Intratraqueal/efectos adversos , Neoplasias Laríngeas/cirugía , Rotura Gástrica/etiología , Anciano , Anciano de 80 o más Años , Humanos , Masculino , Recurrencia Local de Neoplasia/cirugía , Neumoperitoneo/etiología
6.
Br J Anaesth ; 92(2): 271-3, 2004 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-14722181

RESUMEN

BACKGROUND: It may be clinically useful to predict the depth of the epidural space. METHODS: To investigate the accuracy of preoperative abdominal computed tomography (CT) in prediction of the distance for low-thoracic epidural insertion, a single group observational study was conducted in 30 male patients undergoing elective major abdominal surgery requiring epidural analgesia for postoperative pain relief. Using the paramedian approach, low-thoracic epidural insertion at T10-11 interspace was performed with a standardized procedure to obtain an actual insertion length (AIL). According to the principles of trigonometry, an estimated insertion length (EIL) was calculated as 1.26 times the distance from skin to epidural space measured from the preoperative abdominal CT. RESULTS: The mean (SD) EIL and AIL were 5.5 (0.7) and 5.1 (0.6) cm, respectively, with a significant correlation (r=0.899, P<0.01). The EIL tended to have a higher value than the AIL (0.4 (0.3) cm). There were significant correlations of both EIL and AIL with weight (P<0.01), BMI (P<0.01), and body fat percentage (P<0.01), but not with height (P>0.05). CONCLUSIONS: We conclude that the preoperative abdominal CT is helpful in prediction of the distance for low-thoracic epidural insertion using the paramedian approach.


Asunto(s)
Analgesia Epidural/métodos , Espacio Epidural/diagnóstico por imagen , Tomografía Computarizada por Rayos X , Abdomen/cirugía , Adulto , Anciano , Anciano de 80 o más Años , Antropometría , Espacio Epidural/anatomía & histología , Humanos , Masculino , Persona de Mediana Edad , Dolor Postoperatorio/prevención & control , Cuidados Preoperatorios
7.
Anaesth Intensive Care ; 32(6): 832-4, 2004 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-15648998

RESUMEN

A fatality associated with epidural analgesia in a patient with an unsuspected brain tumour has not been reported in the literature. We describe a case of postoperative lumbar epidural analgesia in a 54-year-old female patient who had an undiagnosed brain tumour and a fatal outcome postoperatively. The factors that potentially contributed to this mishap and the possible alternative management of this patient are discussed.


Asunto(s)
Analgesia Epidural/efectos adversos , Neoplasias Encefálicas/diagnóstico , Errores Diagnósticos , Histerectomía/métodos , Hipertensión Intracraneal/diagnóstico , Dolor Postoperatorio/tratamiento farmacológico , Analgesia Epidural/métodos , Analgésicos/uso terapéutico , Neoplasias Encefálicas/complicaciones , Resultado Fatal , Femenino , Humanos , Histerectomía/efectos adversos , Hipertensión Intracraneal/complicaciones , Leiomioma/diagnóstico , Leiomioma/cirugía , Persona de Mediana Edad , Dolor Postoperatorio/diagnóstico , Medición de Riesgo , Tomografía Computarizada por Rayos X , Neoplasias Uterinas/diagnóstico , Neoplasias Uterinas/cirugía
9.
Br J Anaesth ; 91(2): 294-6, 2003 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-12878635

RESUMEN

Metallic tracheal stents have been used in the treatment of paediatric tracheomalacia for more than a decade. We describe a case in which critical airway obstruction occurred during removal of a welded tracheal stent using a rigid bronchoscope under general anaesthesia. Life-saving cardiopulmonary bypass was instituted urgently, and the welded stent was then removed successfully by directly opening the trachea.


Asunto(s)
Puente Cardiopulmonar , Remoción de Dispositivos/métodos , Cuerpos Extraños/cirugía , Stents , Tráquea , Enfermedades de la Tráquea/cirugía , Obstrucción de las Vías Aéreas/etiología , Remoción de Dispositivos/efectos adversos , Cuerpos Extraños/etiología , Humanos , Lactante , Masculino , Stents/efectos adversos , Enfermedades de la Tráquea/etiología
10.
Br J Anaesth ; 88(4): 590-2, 2002 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-12066740

RESUMEN

A case of an infant receiving orthotopic heart transplantation with over-sized donor heart was reported. Left lower pulmonary venous obstruction after sternotomy closure was detected by transoesophageal echocardiography (TOE) and the decision to delay sternal closure was made and the clinical outcome was very satisfactory. The usefulness of intraoperative TOE monitoring and postoperative TOE follow-up for infant heart transplantation, especially in those cases of size mismatch, was well demonstrated.


Asunto(s)
Ecocardiografía Transesofágica , Trasplante de Corazón , Complicaciones Intraoperatorias/diagnóstico por imagen , Monitoreo Intraoperatorio/métodos , Enfermedad Veno-Oclusiva Pulmonar/diagnóstico por imagen , Humanos , Lactante , Masculino , Cuidados Posoperatorios/métodos , Enfermedad Veno-Oclusiva Pulmonar/etiología , Esternón/cirugía
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA