Asunto(s)
Placenta Previa/cirugía , Complicaciones del Embarazo/cirugía , Hemorragia Uterina/prevención & control , Útero/irrigación sanguínea , Adulto , Pérdida de Sangre Quirúrgica , Cesárea/métodos , Femenino , Estudios de Seguimiento , Hemostasis Quirúrgica/métodos , Humanos , Ligadura , Placenta Previa/diagnóstico , Embarazo , Complicaciones del Embarazo/diagnóstico , Tercer Trimestre del Embarazo , Medición de Riesgo , Resultado del Tratamiento , Hemorragia Uterina/cirugía , Útero/cirugíaRESUMEN
BACKGROUND: Very few clinical studies have been conducted in South Africa to assess the value and efficacy of traditional herbal medicines that are commonly used by traditional healers for the treatment of HIV-positive patients. OBJECTIVE: To assess efficacy of a South African traditional herbal medicine in reducing viral load and increasing CD4+T cell counts of HIV/AIDS patients. DESIGN: A descriptive, prospective, follow-up study of 33 HIV-positive volunteers over a one year period. Viral load and CD4 counts were taken three times from each participant. SETTING: From November 2001 to October 2002, patients were treated at the Rustenburg Community Based Centre for traditional therapy. Clinical and paraclinical treatments and screening of patients were done at Pretoria Gynaecological Hospital. PARTICIPANTS: Seven men and 26 women aged between 22 and 43 years took part in a 12-month long follow-up study. HIV monitoring was done at the beginning and after 4 and 8 months in symptomatic and asymptomatic patients with CD4 counts below 200 cells/mm3 or viral load counts above 10,000 copies. INTERVENTION AND ASSESSMENT: ab mitio and after 4-months, viral load, CD4+T cell count, FBC, LFT, glycaemia, U/E, cholesterol, pap smear, clinical and subjective assessment, modern drugs plus hospitalisation for opportunistic infections and resuscitation where needed, powder or suspension of herbal medicine followed by meals. MAIN OUTCOME MEASURES: Improvement in overall health condition and immune system, increase in CD4+T cell count and decrease in viral load count. The two sample paired t-test was used to compare initial and final counts at the 5% level of significance and power of 80%. Ninety five per cent confidence intervals were obtained for differences between mean values. RESULTS: After four and/or eight months of therapy, significant health improvement was achieved: better physical appearance (80% of patients), increased appetite (65%), feeling of well-being (60%), disappearance of skin marks (70%) and urogenital lesions (100%), resumption of workplace duties (60%), weight gain (80%), significant reduction in viral loads (85.4%, p = 0.0015) and significant increase in CD4+ T cell counts (226%, p = 0.0000). CONCLUSION: Achievement of health improvement within eight months indicates that herbal medicine can be used as supplementary or alternative treatment for HIV/AIDS patients, and that it is an obvious immune system booster and probable "virus-cidal" factor. The apparent safety and efficacy of herbal medication warrants further research with a larger sample size of study.
Asunto(s)
Infecciones por VIH/tratamiento farmacológico , Fitoterapia , Adulto , Recuento de Linfocito CD4 , Femenino , Estudios de Seguimiento , Humanos , Masculino , Estudios Prospectivos , Calidad de Vida , Sudáfrica , Carga ViralAsunto(s)
Cesárea/estadística & datos numéricos , Maternidades/normas , Hospitales Privados/normas , Evaluación de Resultado en la Atención de Salud , Resultado del Embarazo/epidemiología , Tasa de Natalidad , Cesárea/efectos adversos , Cesárea/normas , Femenino , Encuestas de Atención de la Salud , Mal Uso de los Servicios de Salud , Maternidades/estadística & datos numéricos , Hospitales Privados/estadística & datos numéricos , Hospitales Públicos/normas , Hospitales Públicos/estadística & datos numéricos , Hospitales de Enseñanza/normas , Hospitales de Enseñanza/estadística & datos numéricos , Humanos , Incidencia , Mortalidad Infantil , Recién Nacido , Mortalidad Materna , Auditoría Médica , Evaluación de Resultado en la Atención de Salud/organización & administración , Selección de Paciente , Embarazo , Estudios Retrospectivos , Sudáfrica/epidemiologíaRESUMEN
OBJECTIVE: To assess external pelvimetry and maternal height, as predictors of cephalopelvic disproportion. DESIGN: Prospective cohort study. SETTING: Four hospitals in Zaire. POPULATION: Six hundred and five nulliparous women. METHODS: Maternal height and external pelvimetry were assessed during the third trimester antenatal visit. Cut off values for considering women at risk for cephalopelvic disproportion were height < 150 cm and external pelvic distances < 10th centile for the population. Logistic regression analysis, combining height and pelvic measurements, was performed to predict women at risk for cephalopelvic disproportion. MAIN OUTCOME MEASURE: Cephalopelvic disproportion was considered when there was caesarean section for failure to progress, vacuum or forceps delivery or intrapartum stillbirth. RESULTS: Cephalopelvic disproportion was present in 42 women. In univariate analysis, height, intertrochanteric diameter and the transverse diagonal of Michaelis sacral rhomboid area were found to be associated with cephalopelvic disproportion. Logistic regression analysis showed that maternal height < 150 cm and/or transverse diagonal < 9.5 cm were the variables most associated with cephalopelvic disproportion. The adjusted odds ratios were 2 x 2 (95% CI 0.9 to 5.4) and 6.5 (95% CI 3.2 to 13.2), respectively. The positive predictive value and likelihood ratio were 24% and 4.0 (95% CI 2.8 to 5.8), respectively. The addition of transverse diagonal to maternal height increased the sensitivity in predicting cephalopelvic disproportion from 21% to 52%. CONCLUSION: In addition to height, transverse diagonal measurement is able to predict one out of two cases of cephalopelvic disproportion in nulliparous women. After validation in a separate cohort, this simple predictive method may be used in peripheral centres for timely referral of pregnant women at risk for cephalopelvic disproportion.