RESUMEN
The use of methotrexate (MTX) has been contraindicated for treatment of severe psoriasis in HIV infection on the basis of six previously reported cases in which MTX appeared to potentiate opportunistic infections and accelerate HIV disease. We describe three HIV-infected patients who were given MTX for severe psoriatic arthritis. In two patients opportunistic infections did not develop. On the basis of survival data, it is not clear that use of MTX adversely affected the natural course of their HIV disease.
Asunto(s)
Artritis Psoriásica/tratamiento farmacológico , Infecciones por VIH/complicaciones , Metotrexato/uso terapéutico , Infecciones Oportunistas Relacionadas con el SIDA/inducido químicamente , Síndrome de Inmunodeficiencia Adquirida/complicaciones , Adulto , Artritis Psoriásica/complicaciones , Contraindicaciones , Humanos , Masculino , Metotrexato/efectos adversosRESUMEN
Treatment of chromoblastomycosis is frequently difficult and unsatisfactory. A representative case is presented of this chronic subcutaneous fungal infection, characterized by warty, cauliflower-like lesions usually on the extremities. Chromoblastomycosis and its treatment are reviewed, with attention to itraconazole, a new triazole compound, as the possible drug of choice.