1.
Org Lett
; 3(1): 83-6, 2001 Jan 11.
Artículo
en Inglés
| MEDLINE
| ID: mdl-11429878
RESUMEN
[figure: see text] A solid-phase route to substituted benzimidazoles has been developed using a modified base-labile linker strategy to release the final products in a traceless manner. This approach permits the synthesis of diverse compounds in moderate yields and high purity.
Asunto(s)
Bencimidazoles/síntesis química , Aminas/química , Bencimidazoles/química , Catálisis , Cromatografía Líquida de Alta Presión , Espectroscopía de Resonancia Magnética , Espectrometría de Masas , Estructura Molecular , Relación Estructura-Actividad
2.
Comb Chem High Throughput Screen
; 4(3): 287-93, 2001 May.
Artículo
en Inglés
| MEDLINE
| ID: mdl-11375743
RESUMEN
An on-line sample preparation method utilizing a time-programmed autosampler is described for high throughput liquid chromatography/mass spectrometry (LC/MS). This approach is particularly helpful for the LC/MS analysis of samples which require solvents incompatible with HPLC in the sample preparation process. The on-line sample preparation approach minimizes a bottleneck in throughput and improves sample recovery under some circumstances.