RESUMEN
Glycosyltransferase VinC was explored for a construction of glycoside libraries using dTDP-vicenisamine and structurally unrelated unnatural aglycons, and new unnatural vicenisaminides were successfully constructed. Structural elements of aglycon recognition by VinC were proposed by modeling studies and were confirmed by the success of transglycosylation upon a designed aglycon.
Asunto(s)
Glicósidos/química , Glicosiltransferasas/química , Glicósidos/síntesis química , Glicósidos/metabolismo , Glicosiltransferasas/metabolismo , Interacciones Hidrofóbicas e Hidrofílicas , Modelos Moleculares , Resonancia Magnética Nuclear Biomolecular , Relación Estructura-ActividadRESUMEN
We have developed the epoch-making contact lens that is equipped with drug delivery system. The hydrogels contain cationic functional group in its side chain were prepared with 2-hydroxyethyl methacylate (HEMA) and methacrylamide propyltrimethylammonium chloride (MAPTAC). The obtained hydrogel is capable to store the anionic drug such as azulene based on ion-exchange reaction. The incorporated anionic drug would be released in physiological condition. The size change of the hydrogel may occur before and after drug release, but we have discovered that the addition of anionic monomer such as methacrylic acid (MAA) and 2-methacryloxyethyl acid phosphate (MOEP) to the above-mentioned composition is effective to prevent the size change, indicating that this hydrogel has the possibility to be applied as a significant drug delivery system device.