RESUMEN
Long-lasting effects of new Russian psychotropic drugs Noopept and Afobazol on active avoidance conditioning and formation of learned helplessness neurosis were studied on an original experimental model in rats. Noopept eliminated the manifestations of learned helplessness after long-term (21-day) treatment by increasing the percent of trained animals. Afobazol was low effective in preventing manifestations of learned helplessness, but if used for a long time, it reduced the incidence of learned helplessness development by increasing the percent of untrained animals.
Asunto(s)
Reacción de Prevención/efectos de los fármacos , Bencimidazoles/uso terapéutico , Trastorno Depresivo/tratamiento farmacológico , Dipéptidos/uso terapéutico , Desamparo Adquirido , Morfolinas/uso terapéutico , Psicotrópicos/uso terapéutico , Animales , Bencimidazoles/farmacología , Dipéptidos/farmacología , Conducta Exploratoria/efectos de los fármacos , Masculino , Morfolinas/farmacología , Psicotrópicos/farmacología , RatasRESUMEN
We studied the effects of new psychotropic preparations noopept and afobazole on acquisition of the conditioned active avoidance response and development of neurosis of learned helplessness in rats. Noopept in doses of 0.05-0.10 mg/kg accelerated acquisition of conditioned active avoidance response and reduced the incidence of learned helplessness in rats. Afobazole in a dose of 5 mg/kg produced an opposite effect, which is probably related to high selective anxiolytic activity of this preparation.
