RESUMEN
The aim of this study was to investigate sacroiliitis in patients with seronegative oligoarthritis. Thirty consecutive patients with seronegative oligoarthritis and no other signs of spondylarthropathy were included. Sacroiliac (SI) joints were investigated by both radiography and magnetic resonance imaging. HLA B27 antigen was studied and family history was reexamined in 2006. Five patients had sacroiliitis. Additionally, 15 patients had HLA B27 antigen or family history of either psoriasis or ankylosing spondylitis. Our conclusion is that during the first decade of seronegative oligoarthritis, HLA B27 antigen, family history, and especially imaging of SI joints reveal in two thirds of the patients the spondylarthritic nature of their disease.
Asunto(s)
Artritis Reumatoide/fisiopatología , Articulación Sacroiliaca/fisiopatología , Adulto , Artritis Reumatoide/diagnóstico por imagen , Artritis Reumatoide/inmunología , Femenino , Antígeno HLA-B27/análisis , Humanos , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Radiografía , Articulación Sacroiliaca/diagnóstico por imagenAsunto(s)
Artritis/diagnóstico , Antígeno HLA-B27 , Dolor de la Región Lumbar/diagnóstico , Imagen por Resonancia Magnética/métodos , Articulación Sacroiliaca , Adulto , Artritis/complicaciones , Enfermedad Crónica , Femenino , Antígeno HLA-B27/sangre , Humanos , Dolor de la Región Lumbar/etiología , Dolor de la Región Lumbar/inmunología , Masculino , Persona de Mediana Edad , Reproducibilidad de los ResultadosRESUMEN
RATIONALE AND OBJECTIVES: The variation of measured magnetic resonance T1 relaxation times of autopsied human muscle samples is confusing. Hence, the authors studied rats' muscles to evaluate the effect of fiber type, the relative area of nonmyofiber space, fat and water content, cell death, and the mechanism of death on proton T1. METHODS: Rats were studied on a 0.1 T magnetic resonance device. We studied how death by cervical dislocation, pentobarbital injection, or a combination of these methods, as well as the amount of time lapsed after death, variably affected T1. RESULTS: Death itself did not affect T1, but the mechanism of death did: rats killed by cervical dislocation after ether anesthesia had longer T1 than those killed with an overdose of pentobarbital. T1 was significantly shorter 1 day after death than at 4 hours after and returned to baseline levels within 4 days after death. Repeated warming caused variation in T1 and obscured other possible changes. CONCLUSIONS: Investigation methods should be strictly controlled and standardized before measurements of the relaxation time, T1, of muscle tissue will provide consistent results.
