RESUMEN
Neuromediated behaviour of feline caudal femoral arteries was studied in vitro. Transmural stimulation of arteries, previously constricted by noradrenaline, caused an up to 58% relaxation of the induced tone. Atropine (10(-5) g/ml) blocked this response by 93%. The removal of endothelium did not affect the magnitude of the response. It is suggested that the caudal femoral artery is an example of a blood vessel which has muscarinic receptors located directly on its smooth muscles.
Asunto(s)
Músculo Liso Vascular/fisiología , Receptores Colinérgicos/fisiología , Vasodilatación , Animales , Atropina/farmacología , Gatos , Estimulación Eléctrica , Arteria Femoral/efectos de los fármacos , Arteria Femoral/inervación , Arteria Femoral/fisiología , Guanetidina/farmacología , Técnicas In Vitro , Músculo Liso Vascular/efectos de los fármacos , Músculo Liso Vascular/inervación , Norepinefrina/farmacología , Perfusión/métodos , Quinacrina/farmacología , Receptores Colinérgicos/efectos de los fármacos , Vasodilatación/efectos de los fármacosRESUMEN
The response to acetylcholine (10(-5) g/ml) was studied on the rat tail artery perfused with Krebs buffer. Perfusion with acetylcholine produced vasodilation (by 69%) in arteries pre-constricted with transmural nerve stimulation. Atropine (10(-6) g/ml) blocked more than 95% of this response. Acetylcholine had a vasodilating effect on arteries pre-constricted with norepinephrine.
