[Sulfinpyrazone-associated renal failure (author's transl)]. / Sulfinpyrazon-assoziierte Niereninsuffizienz.

Three patients developed renal failure a few days after onset of sulfinpyrazone administration. In two the renal dysfunction was reversible, while the third died of a second myocardial infarction. The clinical picture of renal failure was uncharacteristic. It is recommended that renal function be tested two to four days after starting sulfinpyrazone, and to discontinue the drug immediately if there is a rise in blood urea nitrogen and creatinine. Since in two of the patients the creatinine values were elevated before sulfinpyrazone had been administered, it is clear that even minor pointers to impaired renal function should be considered as contraindications to the use of sulfinpyrazone.

[Profound granulocytopenia in a patient treated with propafenon ]. / Fallbericht einer schweren, möglicherweise propafenonverursachten Granulozytopenie.

A case report concerning a 75 year old female patient whose treatment of multifocal ventricular extrasystoles and a ventricular tachycardia after an acute myocardial infarction consisted of multiple drugs, one of them being the antiarrhythmic substance Propafenon, is given. The patient developed a profound, but reversible, granulocytopenia, which disappeared nine days after discontinuing of most of the drugs. With the exemption of Propafenon all of the drugs were reinstituted after the remission: The not anymore needed ones only for a few days, all others until now, without ill effect. The patient is doing fairly well one year after this episode.