[Clinical study of termination of early pregnancy by combination of dl-15-methyl-prostaglandin F2 alpha and RU 486].

PIP: In order to study the appropriate dosage in using RU 486 for induced abortion, 80 women of or = 49 days of pregnancy were randomly assigned to 3 groups. 20 women in Group I took 175 mg of RU486 in 3 1/2 days and were given 1 mg injection of prostaglandin (PG) on the 4th day. 20 women in Group II took the same amount of RU486 as group I and were given 0.5 mg of PG injection on the 4th day. 40 women in Group III took 100 mg of RU486 in 2 days and were given 0.5 mg of PG on the 3rd day. The duration of induced abortion and bleeding and the side effects were observed. The outcome of induced abortion was classified as complete abortion, incomplete abortion, and failure. No failures occurred. About 95% of the women in each group had a complete abortion, and the differences among the 3 groups were not statistically significant. Those who had an incomplete abortion received a medical abortion. A small number of women experienced the side effects of dizziness, nausea, vomiting, and diarrhea. Compared with studies with a similar proportion of complete abortion, the dosage of RU486 in this study is 2-4 times smaller, and the dosage of PG is also reduced by 5 to 14 times that used in earlier studies. Signs of incomplete abortion should be closely observed, and action should be taken to avoid excessive bleeding or infection. Drug-induced abortion is gradually gaining acceptance; nevertheless, appropriate medical attention is necessary to guard against complications.^ieng

[Immunohistochemical study of thymus in patients with congenital heart disease or rheumatic heart disease].

A series monoclonal antibodies were used to study the intrathymic distribution of T and B cells and the process of intrathymic differentiation of T cells on frozen sections of 14 patients' thymuses by a more sensitive immunohistochemical method. The observation indicated that most of the cortical lymphocytes reacted with Leu 1, Leu 2 a, Leu 3 a and Leu 4 antibodies, thus indicating coexpression of multiple antigen on cortical lymphocytes. In cortex, the numbers of Leu 1 and Leu 4 positive cells were less than medulla. In contrary, the numbers of Leu 2 a and Leu 3 a positive cells in the cortex were more than the medulla: and the medullary thymocytes showed segregation into Leu 2 a+ Leu 3 a- and Leu 3 a+ Leu 2 a- subsets. The ANAE+ and AIG 3+ cells were almost limited to the medulla. Hence, the staining profile of medulla approximated the staining pattern of peripheral T cell subsets, which were programmed for their respective role as helper and suppressor cells. Our results supported the conclusion that the mature T cells presented in the medulla were derived from the immature cells in the cortex. In addition, the expression of Leu 7 was not only limited to the NK cells scattered in the medulla, but also found at the cortical-septa border. On the other hand, a small number of B lymphocytes scattered in the medulla stained with Leu 14, OKB-2, BA-1 and IgM antibodies. The Hassall's corpuscles were cross reaction with the B cell antibodies mentioned above; while the epithelial cells in thymic parenchyma were only stained with IgM antibody. Based on these findings we conclude that the human thymus predominantly consist of T cells, but it also contains a fraction of B cells and epithelial cells.