RESUMEN
Circular RNAs (circRNAs) are stable non-coding RNAs characterized by the absence of the conventional 5' cap and 3' polyadenylated tail structure. Its involvement in various aspects of cancers underscores its significance in oncology. Elevated expression of circ_0000620 was observed in both lung adenocarcinoma (LUAD) tissues and cell lines. In vitro, experiments demonstrated that the downregulation of circ_0000620 increased cisplatin sensitivity and promoted cell apoptosis while suppressing malignant characteristics such as cell migration and proliferation. Further investigation into the mechanism underlying the increased expression of circ_0000620 revealed that Methyltransferase 3, N6-Adenosine-Methyltransferase Complex Catalytic Subunit (METTL3) mediates the m6A methylation modification of circ_0000620, thereby promoting its stability and expression. Furthermore, circ_0000620 modulates the miR-216b-5p/KRAS axis to influence apoptosis and cisplatin sensitivity in both A549 and H1299 cell lines. These findings were corroborated by in vivo nude mouse experiments, which showed that knockdown of circ_0000620 inhibited tumor growth and proliferation. In summary, METTL3 plays a role in regulating the stability of circ_0000620 expression, and circ_0000620 exerts its effects on LUAD apoptosis and cisplatin sensitivity through the miR-216b-5p/KRAS signaling pathway.
RESUMEN
This paper analyzes the received power distribution of a generalized indoor visible light communication (VLC) system. The generalization includes: both ceiling-mounted and wall-mounted layouts are considered on the transmitting end to cover some special scenarios; a generally applicable sum-of-sine luminous intensity pattern (SSLIP) is used to fit light emitting diodes (LEDs)' radiation curve; the receiver is considered to have a large light receiving area (LRA) with non-uniformly distributed received power. Through mathematical calculation, the expression of received power at any point of the room is derived. Using the expression, the impact of transmitting LEDs' radiation pattern on received power performance is investigated. It is suggested that in the ceiling-mounted scenario, the LED transmitters with sharp luminous intensity patterns have bigger received power variations and shorter optimal receiving distances. In the wall-mounted case in contrast, sharp luminous intensity patterns lead to smaller received power variations and longer optimal receiving distances.
