1.
J Org Chem
; 87(13): 8544-8550, 2022 07 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-35687873
RESUMEN
A simple, efficient and highly regioselective method for the preparation of 3,4- and 4,5-disubstituted N-methylpyrazoles in a one-pot procedure is reported. The methodology developed was based on the regiochemical control of the reaction of 4-acyl-1H-pyrrole-2,3-diones and methylhydrazine with an influence of the addition or absence of acid and the substrate structure.