RESUMEN
The antibody profiles against Epstein-Barr virus were studied in 136 patients presenting with chronic fatigue syndromes. These profiles were compared with a panel of sera from blood donors. The patients exhibited higher titres in a combined assay for antibodies to the Restricted (R) and Diffuse (D) components of the Early Antigen complex than controls (P less than 0.001) but titres against these antigens were not useful on an individual patient basis. The patients who displayed elevated titres of antibodies to Early Antigens did not differ clinically from those displaying titres in the control range. Four of nine patients who had increased antibodies to Early Antigens also had evidence of active enterovirus infection.
Asunto(s)
Anticuerpos Antivirales/sangre , Síndrome de Fatiga Crónica/inmunología , Herpesvirus Humano 4/inmunología , Adulto , Antígenos Virales/inmunología , Donantes de Sangre , Femenino , Humanos , Masculino , Persona de Mediana EdadRESUMEN
The case is reported of a 17-year-old male with secondary glaucoma and retinochoroiditis complicating acute clinical infectious mononucleosis. The diagnosis was confirmed by Epstein-Barr virus specific serology. Toxoplasmic infection was initially suspected. The differential diagnosis and relevant literature are discussed.
Asunto(s)
Coriorretinitis/etiología , Mononucleosis Infecciosa/complicaciones , Enfermedad Aguda , Adolescente , Coriorretinitis/diagnóstico , Humanos , Mononucleosis Infecciosa/diagnóstico , MasculinoAsunto(s)
Proteínas de la Cápside , Trasplante de Corazón , Trasplante de Corazón-Pulmón , Infecciones por Herpesviridae/etiología , Trasplante de Pulmón , Adolescente , Adulto , Anticuerpos Antivirales/biosíntesis , Antígenos Virales/inmunología , Niño , Infecciones por Herpesviridae/microbiología , Herpesvirus Humano 4 , Humanos , Inmunoglobulina G/biosíntesis , Inmunoglobulina M/biosíntesis , Linfoma no Hodgkin/tratamiento farmacológico , Linfoma no Hodgkin/etiología , Masculino , Persona de Mediana Edad , Complicaciones Posoperatorias/etiologíaRESUMEN
Nigerian patients with tumors of the jaw were compared with controls in respect of antibodies to the viral capsid antigens of Epstein-Barr Virus (EBV) and of total immunoglobulin levels. Immunoglobulin levels did not differ between patients and controls but increased two weeks postsurgery. Immunoglobulin A (IgA) antibodies to EBV were detected in a small number of patients, and mean titers of IgG antibodies to EBV were lower in the patient group, indicating a lack of association between EBV and tumor formation. An association was noted between the presence of Hepatitis B surface antigen, and depressed antibody titers to EBV in patients with tumors. Of 78 patients studied, 12% were Hepatitis B surface antigen positive.
Asunto(s)
Ameloblastoma/microbiología , Neoplasias Maxilomandibulares/microbiología , Infecciones Tumorales por Virus/microbiología , Anticuerpos Antivirales/análisis , Cápside/inmunología , Antígenos de Superficie de la Hepatitis B/análisis , Antígenos e de la Hepatitis B/análisis , Herpesvirus Humano 4 , Humanos , Inmunoglobulina A/análisis , Inmunoglobulina G/análisis , Inmunoglobulina M/análisis , Neoplasias Maxilomandibulares/inmunología , Nigeria , Infecciones Tumorales por Virus/inmunologíaRESUMEN
This study was designed to examine prospectively the incidence of perioperative complications associated with elective tracheostomy in critically ill patients. An experienced surgeon and anesthesiologist participated in every tracheostomy procedure. In 81 procedures, there was no loss of airway control for greater than 20 sec, no airway obstruction, no blood loss exceeding 50 ml, and no aspiration. One patient (1.2%) had cardiovascular instability. During the next 48 h, two patients (2.4%) required wound packing to control hemorrhage but did not require blood transfusion and two patients (2.4%) had evidence of supraclavicular subcutaneous emphysema that was physiologically inconsequential. There was no perioperative mortality or major morbidity associated with the tracheostomy procedure. We conclude that, under controlled conditions, elective tracheostomy can be performed safely in critically ill patients.
Asunto(s)
Traqueotomía/efectos adversos , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Cuidados Críticos , Femenino , Humanos , Complicaciones Intraoperatorias , Masculino , Persona de Mediana Edad , Complicaciones Posoperatorias , Estudios ProspectivosRESUMEN
A strain of Semliki Forest virus (A7) which is avirulent in adult mice killed baby mice in a similar manner to strain V13 which was also virulent for adult mice. In the muscle and brains of baby mice A7 and V13 replicated and produced haemagglutinating activity similarly. Our previous suggestion that defective interfering particles were present in the brains of A7-infected adult mice appears not to be so. The interference formerly detected was due to an inhibitor present in brain tissue of adult and baby mice both normal and infected. Homogenates of A7-infected adult brain produced normal RNA species in BHK cells and not those characteristic of defective interfering particles. Organ culture experiments indicated that avirulence of A7 was not due to lack of release of virus from infected adult brain cells. Also, A7 as well as V13 was detected and was probably replicating in all parts of the brain and spinal cord that were sectioned and examined. Evidence is presented that suggests that the reason for the avirulence of A7 for adult mice compared with its virulence for baby mice may relate to a lower ability to replicate in brain tissue per se rather than to interaction with host defence mechanisms.