RESUMEN
Sixty-seven-year-old male presented with abdominal pain, nausea, vomiting, and decreasing level of consciousness. He was tachycardic but not hypotensive. Computed tomography scan revealed a peripherally enhancing adrenal mass and evidence of low cardiac output state. He was admitted to the intensive care unit but expired within 12 h. Autopsy determined the cause of death as acute coronary insufficiency and identified the adrenal mass as a pheochromocytoma. The pheochromocytoma may have maintained blood pressure in the setting of cardiogenic shock and delayed diagnosis of myocardial infarction.
Asunto(s)
Neoplasias de las Glándulas Suprarrenales/complicaciones , Presión Sanguínea/fisiología , Infarto del Miocardio/complicaciones , Feocromocitoma/complicaciones , Choque Cardiogénico/complicaciones , Neoplasias de las Glándulas Suprarrenales/patología , Neoplasias de las Glándulas Suprarrenales/fisiopatología , Anciano , Diagnóstico Tardío , Resultado Fatal , Humanos , Masculino , Infarto del Miocardio/patología , Infarto del Miocardio/fisiopatología , Feocromocitoma/patología , Feocromocitoma/fisiopatología , Choque Cardiogénico/patología , Choque Cardiogénico/fisiopatologíaRESUMEN
BACKGROUND: The present pilot study was designed to test the impact of passive acute normobaric hypoxic exposure (PAH) and passive short-term normobaric hypoxic exposure (PSH) conditions on energy expenditure (EE) and substrates utilisation (glucose and lipid oxidation). METHODS: Eleven participants have completed the PAH session while the control group (CG) underwent a simulated experimental condition in normobaric normoxic condition. A subset of 6 participants underwent an additional six 3-hour sessions on consecutive days. Metabolic rates were obtained pre- and post-treatments on the morning following an overnight (12 hours) fast in PAH, PSH, and CG groups. RESULTS: The statistical outcomes showed a significant increase in EE for PAH, control, and PSH while a shift in substrate utilization towards lipid sources was only detected for PAH and PSH, respectively. CONCLUSION: This pilot study showed that passive acute normobaric hypoxic exposure did affect EE and fuel utilization in sedentary overweight males and that further passive normobaric hypoxic exposures (PSH) magnified these metabolic adjustments. These outcomes provide valuable information for further research in the area of hypoxia as a new therapeutic strategy to improve the management of weight loss.
