A prospective, randomised double-blind study on the anaesthetic effect of dexmedetomidine hydrochloride in brainstem tumour surgery.

CONTEXT: Brainstem tumour surgery is difficult, and accidents can easily occur. OBJECTIVE: To explore the effect of dexmedetomidine hydrochloride on brainstem tumour surgery. DESIGN, SETTING AND PARTICIPANTS: A total of 60 patients with brainstem tumours successfully operated on by our hospital from March 2016 to March 2018 were selected as subjects. INTERVENTIONS: These patients were randomised into two groups: the research group (n = 30) and control group (n = 30). Patients in the control group were given propofol together with a placebo (0.9% sodium chloride solution) to maintain anaesthesia after general anaesthesia, while patients in the research group were supplemented with dexmedetomidine hydrochloride. MAIN OUTCOME MEASURE: Awakening time, overall stability of various indicators in the operation and adverse reactions during the awakening period were observed. RESULTS: The results revealed that patients in the research group had a longer awakening time, higher mean stability rate, higher effective rate and less incidence of adverse reactions during the awakening period than the control group; the differences were all statistically significant (P < 0.05). CONCLUSION: Dexmedetomidine hydrochloride has a good analgesic effect in intraoperative anaesthesia during brainstem tumour surgery, which significantly reduces the incidence of adverse reactions. Therefore, it can be used to assist anaesthesia during brainstem tumour operations and is worthy of clinical popularisation and application.

[The clinical significance of S100ß protein in cerebrospinal fluid and serum from the patients with cerebral hemorrhage].

AIM: To observe the change and the clinical significance of S100ß protein level in cerebrospinal fluid and serum from the patients with cerebral hemorrhage (CH). METHODS: ELISA was used to detect the expression of S100ß protein in CSF and serum from CH patients control with Inguinal Hernia or great saphenous varix patients. Meanwhile, rabbit CH model at 6 h, 12 h, 24 h, 48 h, 72 h and 96 h . RESULTS: The levels of CSF S100ß protein at acute stage of CH patients increased significantly compared with those at recovery stage of CH patients and control group(P<0.01). The levels of S100ß protein in CSF from CH patients increased significantly compared with those in serum (P<0.01).The levels of S100ß protein in CSF of rabbit experimental group increased significantly compared with those of sham operation group at different time points(P<0.01). CONCLUSION: The level of S100ß protein in CSF from CH patients increases. It may be a biomarker as reflecting degree of pathogenetic and predicting outcome in the CH patients.