RESUMEN
Despite tremendous efforts, bacterial infection and contamination remain a major clinical challenge to modern humans. Nanozyme materials with stimuli-responsive properties are expected to be powerful tools for the next generation of antibacterial therapy. Here, MoS2 nanosheet was firstly prepared by liquid phase exfoliation method, and Pt-MoS2 hybrid biomaterial was then successfully synthesized by a simple self-reduction method. The Pt decoration significantly improves the photothermal effect of MoS2 nanosheet under 808 nm NIR laser irradiation. Besides, benefiting from the formation of heterogeneous structure, the Pt-MoS2 has significantly enhanced peroxidase mimetic catalytic activity, which can kill bacteria through catalysis of H2O2 to generate antimicrobial hydroxyl radicals. Moreover, the temperature rise brought about by NIR laser stimulation further amplifies the nanozyme activity of the composites. After treatment by the synergistic platform, both Staphylococcus aureus and Escherichia coli can be effectively inhibited, demonstrating its broad-spectrum antibacterial properties. In addition, the developed antibacterial Pt-MoS2 nanozyme have the excellent biocompatibility, which makes them well suited for infection elimination in biological systems. Overall, this work shows great potential for rationally combining the multiple functions of MoS2-based nanomaterials for synergistic antibacterial therapy. In the future, the Pt-MoS2 nanozyme may find wider applications in areas such as personal healthcare or surface disinfection treatment of medical devices.