[Effects of cisplatin on telomerase activity of human choroidal melanoma cells].

OBJECTIVE: To study the effects of CDDP (cis-dichlorodiamine platinum) on the telomerase of human choroidal melanoma cells and to investigate the toxic effects of CDDP on these cells. To study the relationship between these two effects and to explore the possibility of using CDDP in the chemotherapy of choroidal melanoma. METHODS: It was an experimental research. CDDP was added to the culture medium of primary cultured human choroidal melanoma cells at different concentrations (0.01, 0.1, 1, 10 and 100 mg/L, 72 h) and times (12, 24, 48, 72 and 96 h, 10 mg/L) and the results were compared with that of the controls. Toxic effects of CDDP were evaluated by MTT test and the level of telomerase was measured by PCR-ELISA assay. The correlation between these two effects was analyzed. RESULTS: The telomerase activity was inhibited by CDDP time dependently and dose dependently. Cell viability was decreased when the concentration of CDDP attained 0.1 mg/L and acted for 24 hours. The cell toxicity of CDDP was correlated negatively (r = -0.900, P = 0.037) with the inhibition of telomerase. The cell death was lagged behind the decrease of telomerase. CONCLUSIONS: CDDP is an effective telomerase inhibitor which can decrease the telomerase activity of cultured human choroidal melanoma cells significantly. This effect is dose and time dependent. CDDP can also cause the death of cultured melanoma cells.

Immunohistochemical study of the presence of mast cells in idiopathic orbital inflammatory pseudotumor: possible role of mast cells in the course of its pathogenesis.

BACKGROUND: It is well known that mast cells (MC) are involved in fibrosis and many forms of chronic inflammation. Chronic inflammatory cells infiltration and fibrosis in various orbital tissues are the main histopathologic features in patients with idiopathic orbital inflammatory pseudotumor (IOIP). Whether MC is involved in the course of chronic inflammatory conditions of IOIP is not yet clear. We sought to investigate the distribution of MCs in samples of IOIP and to explore the possible role of MC in the course of its pathegenesis. METHODS: Immunohistochemistry with tryptase monoclonal antibody (a specific mast-cell surface marker) was used in 53 different subtypes of IOIP specimens including 19 of the lymphocyte infiltrative type, 22 of the fibrotic type, 12 of the mixed type and 4 specimens of normal orbital tissue. The number of positive stained MC was counted by light microscopy. The differences of the number of MC between various subtypes of IOIP were analyzed. RESULTS: The average number of positive stained MC in the normal control group was 33.33 +/- 4.72 /mm(3), whereas the average numbers of positive stained MC in the lymphocyte infiltrative subtype group, the mixed subtype group and the fibrotic subtype group were 306.35 +/- 55.81 /mm(3), 662.93 +/- 115.28 /mm(3) and 813.44 +/- 146.56 /mm(3), respectively. Compared with the normal control, the number of MC increased significantly in all three subtypes of IOIP samples (P < 0.01). The number of MC in fibrotic subtype IOIP was the largest, followed by mixed subtype IOIP, and the lymphocyte infiltrative subtype IOIP (P < 0.05). The MC were distributed mainly around small vessels and in collagen fibers. CONCLUSION: Mast cells may play an underappreciated role in the fibrosis of IOIP.

Features associated with recurrence of idiopathic orbital inflammatory pseudotumor.

PURPOSE: To explore factors which lead to recurrence of idiopathic orbital inflammatory pseudotumor (IOIP). METHODS: Idiopathic orbital inflammatory pseudotumor in 209 cases between Jan 1, 1978 and Dec 31, 1999 in our hospital was evaluated retrospectively. The comparison of clinical and pathological parameters between patients with at least one episode of recurrence and those with no recurrence at all was performed and analyzed using logistic regression method. RESULTS: Follow-up results (with a mean follow-up time of 3.4 years, ranging from 0.5 year to 21.0 years) showed that the recurrence rate of IOIP was 41%. Sex and proptosis were associated with the recurrence of IOIP. Male gender was more likely to relapse than female counterparts, with the male being 52% and female being 25%. The severer the proptosis is, the higher the rate of recurrence. Among the clinical subtypes of IOIP, the rate of recurrence (17%) in cases with dacryoadenitis was the lowest, followed by anterior local orbital mass (44%), posterior orbital mass (54%), myositis (75%) and diffuse subtype (100%). However, the clinical subtypes did not show significant relationship with the recurrence of IOIP. CONCLUSIONS: Male gender and severe proptosis are associated with a higher recurrent rate in patients with IOIP.

[A preliminary study in establishment of mice model of experimental uveal melanoma].

OBJECTIVE: To explore the methods to establish a nude mice model of experimental uveal melanoma by the implantation the primary cultured cells into anterior chamber or subcutaneous injection. METHODS: 35 nude mice, which applied with the SPF grade standard by national healthy department, were divided into 3 groups: anterior chamber group (15), subcutaneous A group (10) and subcutaneous B group (10), respectively. (2 - 3) x 10(5) melanoma cells were inoculated into the anterior chamber of each nude mouse, while 2 x 10(6) cells were inoculated into every subcutaneous of the hind legs in A group. Besides this, the fresh mass of the tumor come from enucleated eye were transplanted into every subcutaneous of the hind legs in B group. Then the condition of transplanted tumor were observed under the slit lamp and naked eye, all nude mice were followed for 3 months the rates of tumor induction were compared. RESULTS: The results of the rates of tumor induction in the 3 groups were 7 (46.6%) of 15, 2 (20%) of 10 and 0 of 10, respectively. The discrepancy were of significance (chi(2) = 7.080, P = 0.029). CONCLUSIONS: Uveal melanoma can be induced successfully by inoculation the primary cultured human uveal melanoma cells into anterior chamber or subcutaneous in nude mice. The results suggest that the ration of the tumor growth is higher in subcutaneous mass transplant than any other groups.

Orbital neurofibroma presenting with a negative Hounsfield unit on computerized tomography.

PURPOSE: To report a case of diffuse orbital neurofibroma which displayed an unusual computed tomography (CT) feature. METHODS: Results of ocular examination, orbital CT examination and pathological findings in a patient with a space-occupying orbital lesion are presented. RESULTS: Orbital CT evaluation of a male patient, aged one and a half years old, revealed a right orbital lesion with a strongly negative value in Hounsfield units. The preoperative diagnosis was a dermoid cyst. An anterior orbitotomy was performed, and the surgical specimen demonstrated a typical plexiform neurofibroma with routine hematoxylin and eosin staining and immunohistochemical studies. CONCLUSIONS: Plexiform orbital neurofibromas may demonstrate a negative Hounsfield value on CT examination.

[Clinical analysis of orbital metastasis from nasopharyngeal carcinoma].

OBJECTIVE: Metastasis of nasopharyngeal carcinoma (NPC) to the orbit has been rarely known. We report 11 patients with metastasis of NPC to the orbit and discuss their clinical characteristics and prognosis. METHODS: Eleven patients with orbital metastasis of NPC who were seen between January 1, 1991 and December 31, 2003 in Zhongshan Ophthalmic Center, Sun Yat-sen University, were retrospectively reviewed. RESULTS: Among 11 patients, there were nine males and two females. The mean age at diagnosis was 45.5 years. The left eye was involved in ten cases, and right eye in one. There were seven patients with a known history of NPC and four with no NPC history at the time of presentation. The seven patients with NPC history developed orbital metastasis at a mean time of 12.7 months (range 2.0 - 60.0 months) after the diagnosis of NPC. The mean duration of eye lesions at presentation was 10.3 months (range 0.7 - 36.0 months). Nine patients developed single metastatic focus and two patients had two foci in the affected orbit. The main component of the tumor was located in the nasal part of the orbit in eight cases, in the temporal part in two, and in the orbital apex in one. The anterior part of the orbit was affected in eight cases. The neoplasm was resected completely or partly through surgery. The diagnosis was histopathologically confirmed as NPC. Among them, four cases were squamous cell carcinomas, two cases lymphoepitheliomas, and five cases unclassified carcinomas. At the last following up examination, five patients had died as a result of disseminated metastasis, one patient had died of unknown cause and three were still alive with no active metastasis. Two patients had lost follow-up. The mean survival time after orbital diagnosis was 21 months. CONCLUSIONS: NPC with orbital metastasis is rare. However, it is the most common primary cancer metastasizing to the orbit in our Center. Most of them were located in the anterior nasal part of the orbit. The prognosis of these metastasis cases is very poor.

[Diagnosis and surgical management of 209 cases of orbital cavernous hemangioma].

OBJECTIVE: To study the clinical features, preoperative diagnosis and surgical choice of orbital cavernous hemangioma. METHODS: Records of all cavernous hemangioma patients (209 cases) who were seen in Eye Hospital, Zhongshan Ophthalmic Center, Sun Yat-sen University from January 1, 1986 to December 31, 2000 were reviewed. RESULTS: Among 209 cases, 123 patients were females and 86 were males. The left orbit was affected in 123 cases and the right orbit in 86 cases. No case was bilaterally involved. The mean age was 39.2 years old, ranging from 5 to 68 years. A painless, gradually progressive proptosis and visual disturbance were the main clinical signs. Ninety-five percent (199/209) of them could be accurately diagnosed preoperatively based on ultrasound scan and CT/MRI examination. The tumors were removed successfully by the surgical procedure of standard lateral orbitotomy in 36% (75/209) of patients and anterior orbitotomy in 64% cases (134/209). CONCLUSIONS: Nearly all patients with cavernous hemangioma could be correctly diagnosed by preoperative image studying. The simple surgical procedure of anterior orbitotomy can be successfully used in about two third of cases with less surgical complication.

Idiopathic orbital inflammatory pseudotumor in Chinese children.

PURPOSE: To study the clinical features of idiopathic orbital inflammatory pseudotumor (IOIP) in Chinese children. METHODS: Pediatric patients with IOIP seen between Jan. 1, 1978 and Dec. 31, 1999 in the Eye Hospital, Zhongshan Ophthalmic Center, Sun Yat-sen University were evaluated retrospectively. Their clinical features were compared with those of adult cases of IOIP. RESULTS: Of the 209 cases, 24 (11.5%) were equal to or less than 20 years old; 14 were female and 10 were male. There were 11 in the right eye, 9 in the left eye and 4 in both eyes. Palpable mass (58%), ocular motility restriction (46%), swollen eyelid (42%), proptosis (42%) and high orbital pressure (42%) were the five most common presenting signs in children with IOIP. Ptosis occurred more often in pediatric IOIP cases (38%) than in adult IOIP cases (9%) (P < 0.0003). However, compared with adult IOIP cases, pediatric patients showed less proptosis (69% vs. 42%, P = 0.0074). According to radiological and surgical findings, a local mass within the orbit was the most frequent subtype (50%), followed by dacryoadenitis (29%), myositis (8%), perineuritis (4%), eyelid pseudotumor (4%), and diffuse orbital inflammation (4%). The frequency of clinical subtypes in children was similar to that in adults. After systemic corticosteroids, surgical management and local radiotherapy the full recovery response rate was 29% and the total effective rate was 92%. CONCLUSIONS: Pediatric IOIP accounted for 11.5% of all IOIP patients. Pediatric cases had more sign of ptosis and less sign of proptosis than in adult IOIP. The full recovery response rate was low in children with IOIP.

Orbital cavernous hemangioma with bone erosion.

PURPOSE: To report a rare computed tomography (CT) feature in one case of orbital cavernous hemangioma (OCH). METHODS: Case report. The clinical features, CT findings, and pathological examination are presented. RESULTS: A 43-year-old Chinese man developed slowly progressive proptosis and decreased vision in his left eye over 13 years. The best-corrected visual acuity was 20/400 OS. Fundus examination showed moderate disc pallor in the left eye. CT scan revealed a 3.7 x 3.5-cm homogeneous soft tissue mass occupying nearly the whole retrobulbar space. There was focal bone erosion of both the deep lateral orbital wall and deep superior wall. At surgery, a 3.5 x 3.0 x 3.3-cm purplish, well-defined, round mass was removed intact without complication. The histopathologic examination proved it to be OCH. One year later, the visual acuity recovered to 20/15. CONCLUSION: Patients with OCH may show bone erosion on CT scan, so the presence of bone defect on CT scan should consider the possibility of OCH.

[Emphasizing the fundamental and clinical research on thyroid-associated ophthalmopathy].

In this article, we discussed the pathogenesis and current status of the research in thyroid-associated ophthalmopathy (TAO). TAO, the most common orbital disease in adults, is an orbital autoimmune disease closely related to Graves' disease. Now, the fundamental and clinical research on TAO should be further enhanced.

Cavernous hemangioma of the bony orbit.

PURPOSE: To study the clinical features, diagnosis and management of intraosseous cavernous hemangioma of the orbit. METHODS: Five cases of intraosseous cavernous hemangioma seen in our hospital from Jan 1, 1986 to Dec 31, 2000 were reviewed. RESULTS: Among all five cases, two were male and three were female. The mean age was 47.6 years old, ranging from 39.0 to 55.0 years. The left orbit was affected in 4 cases and the right one in 1 case. The bony involvement occurred in frontal bone (two cases), zygomatic bone (two cases) and sphenoid bone (one case). A painless, slowly enlarging hard bony mass fixed to the bone with no pulsations was the main clinical sign. The x-ray and CT appearance of intraosseous cavernous hemangioma of the orbit were characteristic and usually diagnostic. The differential diagnosis of it included fibrous dysplasia, eosinophilic granuloma, multiple myeloma and metastatic carcinoma. Treatment is local removal of the bone containing the tumor. CONCLUSIONS: Intraosseous cavernous hemangioma is a rare tumor of the orbit and usually has good surgical result.

Culture and differentiation of human orbital preadipocytes in thyroid-associated ophthalmopathy.

PURPOSE: To identify whether there are preadipocytes in the orbits of thyroid-associated (TAO) patients and whether they possess the capacity to undergo ophthalmopathy adipocytic differentiation. METHODS: Orbital fat tissue from TAO patients was placed in primary culture and proliferating cells were sub-passaged. The preadiocytes were identified with immunohistochemistry. Confluent preadipocytes were subjected to a differentiation protocol. And Peroxisome proliferators-associated receptory (PPARgamma) transcript levels were determined before and after differentiation. RESULT: In primary culture, cells were spindly and showed positive immunostaining for preadipocyte factor-1 (pref-1) protein. During the process of differentiation, orbital cells showed evidence of adipogenesis and relatively greater PPARy gene expression with differentiation. CONCLUSION: There are active preadipocytes in the orbital tissue of TAO patients which might be able to undergo adipocyte differentiation. These observations suggest that the preadipocytes differentiation contributed to excess orbital adipose tissue volume in TAO.

The drug sensitivity of cyclosporine A combined with antineoplastic drugs in retinoblastoma in vitro.

PURPOSE: To study cyclosporine A inhibition on the fresh retinoblastoma cells in vitro and increasing the drug sensitivity after combined with different antineoplastic drugs. METHODS: To study the growth curve of cyclosporine A on 27 samples of primary retinoblastoma cells by MTT assay and to study the change of the drug sensitivity by cyclosporine A combined with seven antineoplastic drugs. RESULTS: The average IC50 of cyclosporine A on the 27 retinoblastoma cells is 67.81microg/ ml and the average inhibitive rate of these samples is 26.1% when cyclosporine A is in the concentration of 2microg/ml. The inhibitive rates all got improved after the seven antineoplastic drugs combined with cyclosporine A and the increasing average inhibitive rate is more than 5. CONCLUSION: Cyclosporine A can inhibit retinoblastoma cells in vitro and its inhibitive effect is dose dependent. Moreover it can enhance the inhibition of multiple antineoplastic drugs on retinoblastoma cells.

The differentiation of idiopathic inflammatory pseudotumor from lymphoid tumors of orbit: analysis of 319 cases.

PURPOSE: To analyze the clinical, morphologic, immunophenotypic, and molecular genetic differences between idiopathic inflammatory pseudotumor and lymphoid tumors of the orbit. METHODS: 209 patients with IOIP and 110 patients with lymphoid tumors seen between January 1, 1978 and December 31, 1999 in Zhongshan Ophthalmic Center, Sun Yat-sen University were evaluated retrospectively. RESULTS: More patients with lymphoid tumors had palpable mass than patients with idiopathic orbital inflammatory pseudotumor (IOIP) (P < 0.0001), with the percentage of 90% and 65%, respectively, whereas more patients with IOIP had swollen eyelid, eyelid or conjunctival congestion, pain, retinal folds or hamorrhage, and optic nerve atrophy than patients with lymphoid tumors, with the percentage of 55% and 40% (P = 0.014), 42% and 24% (P = 0.001), 24% and 1% (P < 0.0001), 14% and 4% (P = 0.004), 7% and 2% (P = 0.043), respectively. Ultrasound and computed tomography/magnetic resonance image (CT/MRI) scan usually could not differentiate IOIP from lymphoma. Nearly one third of patients with IOIP could not be easily differentiated pathologically from lymphoid tumor. Immunophenotypic, and molecular genetic analyses can differentiate IOIP from lymphoid tumor based on polyclonal or monoclonal proliferation of lymphocytes with the IOIP being polyclonal and lymphoma monoclonal. CONCLUSIONS: Idiopathic orbital inflammatory pseudotumor and lymphoid tumor showed distinguishing clinical, morphologic, immunophenotypic, and molecular genetic characteristics.

Measurement of intraocular concentrations of etoposide after systemic and local administration.

PURPOSE: To determine and compare the concentrations of etoposide achieved in the aqueous and vitreous humors after intravenous and subconjunctival administration. METHODS: Eight New Zealand rabbits were treated with etoposide (5mg/kg) intravenous and etoposide (2.5 mg/ml, 0.5 ml) subconjunctival respectively. The samples of the aqueous and vitreous humors of rabbits were drawed at 1, 2, 3 hours after the end of infusion. The concentrations of the etoposide were determined by high-performance liquid chromatography. A Diamonsil TM C18 column ( 6 x 40 mm, 3 microm ) with a mobile phase of 400 ml of methanol and 600 ml of 100 mmol x L(-1) sodium dihydrogen phosphate with 0.02 mmol x L(-1) dioctyl sodium sulfosuccinate and 0.5% triethylanine (pH value was adjusted to 6 by phosphoric acid) was used. The detective wavelength was at 235 nm and the flow rate was 1.0 ml x min(-1). RESULTS: The concentrations of etoposide in aqueous and vitreous humors after administrated in intravenous for 1, 2, 3 hours were 38.5, 52.2, 44.1(ng/ml) and 12.0, 25.1, 18.0 (ng/ml) respectively. The concentrations of etoposide in aqueous and vitreous humors after infused in subconjunctival for 1, 2, 3 hours were 98.0, 113.0, 99.0 (ng/ml) and 43.7, 66.7, 32.4 (ng/ml) respectively. The concentrations in the aqueous and vitreous humor after local administrated were 2 to 4 times higher than those obtained after intravenous administration. There are statistical significance between the concentrations of etoposide of aqueous and vitreous humor after intravenous and subconjunctival administration. CONCLUSIONS: The delivery of subconjunctival of etoposide results in higher concentrations in aqueous and vitreous humors than intravenous administration. These results suggest that local administration of chemotherapeutic agents should be more effective for retinoblastoma chemotherapy than systemic administration.

Cavernous hemangioma of the orbit: analysis of 214 cases.

The records of all patients with orbital cavernous hemangioma managed at Zhongshan Ophthalmic Center, Sun Yat-sen University from Jan. 1, 1986 to Dec. 31, 2000 (n = 214) were reviewed retrospectively. Among them, 126 patients were female and 88 were male. The mean age was 39.4 years, ranging from 5.0 to 68.0 years. The left orbit was affected in 127 cases and the right one in 87 cases. No case showed bilateral involvement. A painless, gradually progressive proptosis and visual disturbance were the main clinical signs. Ninety-three percent of the patients (199/214) could be accurately diagnosed preoperatively based on echography and CT/MRI. The tumors were removed successfully by standard lateral orbitotomy in 35% (75/214) and by anterior orbitotomy in 65% (139/214). Anterior orbitotomy has become an important surgical procedure in the treatment of orbital cavernous hemangioma with excellent effect.

[Clinical analysis of 339 cases of thyroid-associated ophthalmopathy].

OBJECTIVE: To summarize the clinical manifestation of thyroid-associated ophthalmopathy (TAO), to analyze the thyroid function and to monitor the therapeutic effect of anti-hyperthyroidism on the progression of TAO. METHODS: Three hundred and thirty nine TAO cases (597 eyes) were collected from 1994 to 2001 and their clinical manifestations were summarize and analyzed. RESULTS: TAO occurred mostly in individuals over 40 years with no gender preference. Exophthalmos and diplopia were the major manifestations and main reasons for ophthalmic examination. Retraction of eyelids and involvement of extraocular muscle were present in over 70% cases. In 339 TAO cases, euthyroidism was found in 93 cases and abnormal thyroid function (hyperthyroidism or hypothyroidism) was present in 246 cases. The V and VI grade of TAO occurred more frequently in patients with abnormal thyroid function than those with euthyroidism. (131)I, oral anti-hyperthyroidism drug, or thyroidectomy was used for all patients with abnormal thyroid function. TAO occurred in 39.3% cases treated with (131)I, in 15.6% cases with oral anti-hyperthyroidism drug, and in 14% cases with thyroidectomy. All ocular pathologic changes occurred after hyperthyroidism had been controlled and hypothyroidism was found in most of these cases. CONCLUSIONS: The condition of thyroid function has a certain relationship to the severity of TAO. Over-fast and undue anti-hyperthyroidism therapy may impact an untoward effect on TAO; immediate and appropriate treatment can improve the effect of therapy on TAO.

[Measurement and the clinical significance for the intraocular concentrations of carboplatin after systemic and local administration in rabbits].

PURPOSE: To investigate and compare the concentrations of carboplatins achieved in the aqueous and vitreous humors after intravenous or subconjunctivaly injection and to investigate whether local administration of carboplatin might result in higher concentrations in the aqueous and vitreous humor. METHODS: Four New Zealand rabbits were treated with carboplatin (18.7 mg/kg) in intravenous. The other 4 rabbits were injected with carboplatin (10 mg/ml 0.5 ml) in right eyes subconjunctivaly. The Samples of the aqueous and vitreous humors of rabbits were drawed at 1, 2, 3 hours after the end of infusion and measured the concentration of carboplatin with atomic absorption spectroscopy. The agent dose of systemic infusion were 8 fold for that in subconjunctival delivery. RESULTS: The concentrations of carboplatin in aqueous and vitreous humors treated with intravenous after 1, 2, 3 hours were 140, 330, 180 ng/ml and 20, 40, 17 ng/ml. The concentration of carboplatin in aqueous and vitreous humors treated with subconjunctively after 1, 2, 3 hours were 2,650, 4,390, 2,780 microg/ml and 160, 250, 110 ng/ml. There is statistical significance between the concentrations of carboplatin of aqueous and vitreous humor after intravenous and subconjunctival (P < 0.01). CONCLUSIONS: The delivery of subconjunctival of carboplatin result in higher concentrations in aqueous and vitreous humors than intravenous administation. The result suggest that local delivery of chemotherapeutic drugs should elevate the intraocular drugs concentration and be effective for retinoblastoma treatment.

Clinical analysis of 106 cases with elevated intraocular pressure in thyroid-associated ophthalmopathy.

PURPOSE: To summarize the clinical manifestation of thyroid-associated ophthalmopathy (TAO) with elevated intraocular pressure (IOP), and to analyze the contributing factors. METHODS: One hundred and six cases (188 eyes) of ocular hypertension in 339 cases (597 eyes) with TAO were collected from 1994 to 2001 and their clinic manifestations were summarized and analyzed. RESULTS: It was demonstrated that the incidence of ocular hypertension in TAO was 31.3%, and was more frequently found in the male than in the female. The elevated IOP in TAO was found to be partially related to compression of the eyeball by enlarged extraocular muscles, the elevated intraorbital pressure as result of the proliferation of intraorbital connective tissue and the enlargement as well as swelling of extraocular muscles. It was also related to the severity of TAO other than the course of TAO. The ocular hypertension in most cases can be controlled with reduction of IOP by methylprednisolone or orbital decompression. CONCLUSION: Specific clinical features were found in TAO patients with ocular hypertension. It should be differentiated with primary glaucoma. The IOP in most cases can be controlled by prompt and effective treatment of TAO.

Angioleiomyoma of the ciliary body: a case report.

PURPOSE: To report a rare case of angioleiomyoma of the ciliary body METHODS: The clinical manifestation, imaging findings, histopathologic characteristics were analyzed in a 32-year-old male patient with angioleiomyoma of the ciliary body. RESULTS: The tumor was removed intact with local resection. Histopathologic examination revealed that the tumor was full of vessels and it was composed of spindle cells with abundant cytoplasm. Immunohistochemical studies showed positive for SMA and Desmin and negative for S100 and HMB-45. CONCLUSIONS: Angioleiomyoma of the ciliary body is a rare tumor that can be successfully treated with local surgical resection in this area. It needs to be differentiated from other tumors, especially malignant melanoma.