Proposta de Sistema de Informação para Atenção Farmacêutica baseado no Método Dáder / Proposal of an Information System for Pharmaceutical Care based on Dader Method

A característica principal do Acompanhamento Farmacoterapêutico, um dos macrocomponentes da Atenção Farmacêutica, é a documentação sistemática de informações para solução dos Problemas Relacionados aos Medicamentos (PRM). Essa documentação é feita, com frequência, de forma não automatizada e com o preenchimento de fichas manuais catalogadas em arquivos, o que dificulta a sua organização e torna o processo de recuperação dos dados exaustivo e complicado, limitando a sua aplicação no cotidiano. Uma maneira de minimizar estes problemas é utilizar um sistema de informação para dinamizar esse processo, facilitar o acesso aos dados da terapia e melhorar a comunicação entre o médico e a equipe de saúde responsável pelo paciente. Este artigo apresenta, portanto, o desenvolvimento de um sistema para Atenção Farmacêutica baseado no método Dáder, denominado Farmatools. Esse sistema tem como objetivo informatizar o método Dáder, facilitando o acompanhamento farmacoterapêutico, otimizando o tempo de visita e melhorando a recuperação de informação e a comunicação entre os profissionais de saúde. O Farmatools visa melhorar o acesso à informação, diminuindo a inacessibilidade e a perda das informações.

These registrations are often not automated, but done by filling manual forms, that are cataloged. Over time, with the increase in attendances, there is an increase in the number of forms (amount of paper), making the recovery data process extensive and complicated, thereby, its application in daily life. One way to minimize these problems is to use an information system to improve the process and facilitate the data access recorded during the visits, improving communication with the doctor and the health care team responsible for the patient. This paper presents Farmatools, anelectronic system for pharmaceutical care based on Dader Method. The system aims to automate the Dader method, facilitating the pharmaceutical monitoring, reducing visit time, improving the information retrieval, as well as the communication between health professionals. Furthermore, Farmatools avoid the pharmaceutical paper records of patients accumulation, the inaccessibility of them and the loss of information.

Enhanced in vitro and in vivo antioxidant activity and mobilization of free phenolic compounds of soybean flour fermented with different beta-glucosidase-producing fungi.

AIMS: To evaluate the soybean polyphenol glucosides bioconversion to aglycone forms by different beta-glucosidases-producing filamentous fungi to enhance their antioxidant activity. METHODS AND RESULTS: Soybean defatted flour was submitted to solid-state fermentation with Aspergillus niger, Aspergillus niveus and Aspergillus awamori. The fungi studied produced approximately the same beta-glucosidase activity units amount when p-nitrophenyl-beta-d-glucopyranoside was used as substrate for the assay. However, electrophoretic analysis, using 4-methylumbellipheryl-beta-d-glucopyranoside as substrate, showed that beta-glucosidase produced by A. niveus was more active. Fermented methanolic extracts showed an increase in polyphenol and genistein contents and antioxidant activities. The highest genistein content was found in soybean fermented by A. niveus. Methanolic extracts of the soybean fermented by the different fungi showed a similar capacity of scavenging H(2)O(2) generated in vivo by the tumour promoter 12-O-tetradecanoyl phorbol-13-acetate. CONCLUSIONS: A. niveus synthesized a beta-glucosidase with higher specificity to hydrolyse genistin beta-glycosidic bond than those produced by A. awamori and A. niger. SIGNIFICANCE AND IMPACT OF THE STUDY: The utilization of these beta-glucosidases-producing fungi in soybean fermentation processes resulted in the obtaining of methanolic extracts with different antioxidant potentials that could be used either therapeutically or as an antioxidant in nonphysiological oxidative stress conditions, as the one induced in skin by UV radiation.