Neiguan (PC6) acupoint stimulation for preventing chemotherapy-induced nausea and vomiting: a cost-effective supplement in guideline-inconsistent chemotherapy-induced nausea and vomiting prophylaxis subgroup.

OBJECTIVE: To assess the efficacy and safety of Neiguan (PC6) acupoint acustimulation in preventing chemotherapy-induced nausea and vomiting (CINV), especially for patients with guideline-inconsistent CINV prophylaxis (GICP) due to personal reasons METHODS: From January 2021 to December 2021, 373 patients suffered from solid malignancy were recruited according to the inclusion criteria. Complete response (no emesis and no rescue medication use) rate during the overall phase (0-120 h of each chemo-cycle) was the primary assessment of CINV control. The Functional Living Index-Emesis (FLIE) questionnaire was investigated among these patients as a secondary 'quality of life' objective to assess the impact of CINV on patients' daily life by recording score of nausea and vomiting. RESULTS: With acustimulation of Neiguan (PC6) acupuncture point through a portable, noninvasive and user-friendly device, in terms of complete response rate and scores in nausea/vomiting by FLIE questionnaire, patients achieve a better outcome in highly emetogenic chemotherapy (HEC) induced CINV, especially GICP subgroup. Meanwhile, analysis also demonstrated this tendency existed in other patients with HEC/GCCP (guideline consistent CINV prophylaxis) and moderate emetogenic chemotherapy, although the difference was not significant. CONCLUSION: Considering advantages of Neiguan (PC6) acustimulation such as noninvasive, covered by medical insurance and few side effects, we believe it would be an ideal auxiliary tool in CINV control, especially in patients who receive highly emetogenic chemo-protocol and are reluctant to GCCP for economic reasons.

Research Progress on Mechanism of Action of DHODH in Progression of Malignant Tumors / 肿瘤防治研究

Dihydroorotate dehydrogenase (DHODH) is a flavin-dependent metabolic enzyme that oxidizes dihydroorotate acid to orotic acid in the de novo synthesis pathway of pyrimidine metabolism. DHODH is located in mitochondria, closely related to cellular oxidative phosphorylation, and an important suppressor of the ferroptosis pathway. This study investigates the influence of DHODH on the progression of malignant tumors, including its important role in the de novo synthesis of pyrimidine, oxidative phosphorylation, and ferroptosis. The objective is to present evidence that DHODH is a potential target for the clinical treatment of tumors.

Influence of the Anatomical Structure on the Hemodynamics of Iliac Vein Stenosis.

Few reports study the effects of the anatomical structure of the iliac vein on hemodynamics and the methods to reduce and delay in-stent thrombosis. The anatomical structure of iliac vein stenosis was used to establish vascular models with different stenosis rates, taper angle, and left branch tilt angle in the work. The influence of anatomical structure on hemodynamics was revealed through theoretical research and in vitro experimental verification. A real iliac vein model was built based on computed tomography angiography (CTA) images, and hemorheological parameters including time-averaged wall shear stress (TAWSS), oscillatory shear index (OSI) and relative residence time (RRT) were analyzed by computational fluid dynamics (CFD). The results showed that iliac vein stenosis could significantly increase the wall shear stress (WSS) of the blood vessels at the stenosis site and outside the intersection area, which was easy to produce eddy currents in the distal blood vessels. With the increased taper angle, the proportion of low-wall shear stress areas and the risk of thrombosis increased. A small tilt angle could aggravate the influence of narrow blood vessels on the blood flow characteristics and vascular wall. The numerical simulation results were consistent with the theoretical research results, and the experimental study verified the correctness of the simulation. The work is helpful to further understand the hemodynamic characteristics of the iliac vein, providing a scientific reference for clinical treatment and diagnosis.

Chinese evidence, practice guidelines and criteria for the diagnosis and treatment of primary headache / 中华神经科杂志

The migraine, tension-type headache and cluster headache are common primary headaches in clinic. The accurate diagnosis and standardized treatment are important to reduce the disability, chronification and medication overuse of primary headache. With the development of clinical research on primary headache, more and more evidence-based medical data provide guidance for clinical diagnosis and treatment. Particularly, new research progresses have been made in the field of both medication and non-drug treatments of primary headache. Above all, Headache Group of Chinese Society of Neurology drafted the Chinese practice guidelines for diagnosis and treatment of migraine, tension-type headache and cluster headache. The purpose of these guidelines is to improve the understanding, management, standardized diagnosis and treatment of primary headaches.

Aerobic training methods for high school soccer / Métodos de treino aeróbico para o futebol de ensino médio / Métodos de entrenamiento aeróbico para el fútbol de la escuela secundaria

ABSTRACT Introduction: Fatigue impairs exercise activity in high school students, and it is detrimental to explore aerobic training when fatigue cannot be alleviated. This factor limits the ability to exploit the full potential of young athletes for soccer. Objective: Implement a healthy development protocol for soccer application in high school. Methods: This article used a literature review among other research methods. The analysis was devoted to aerobic training for endurance in soccer for students in high school. The specific methods of implementing the developed protocol in high schools were studied. Finally, effective measures for improving students' physical fitness were presented. Results: Judging from the situation, the duration of each training session in high school soccer is closely related to the coaches' ability. High-level coaches tend to organize the duration of training according to the perceived effects in soccer practice, considering the physical and technical characteristics of the sport itself. Conclusion: Soccer endurance training can also promote the long-term development of soccer education while meeting students' actual exercise needs. It is important to carry out soccer aerobic training applied to high school. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.

RESUMO Introdução: A fadiga prejudica a atividade do exercício físico nos alunos do ensino secundário, sendo prejudicial explorar os treinos aeróbicos quando a fadiga não pode ser aliviada. Esse fator limita a capacidade de explorar o máximo potencial de jovens atletas para o futebol. Objetivo: Implementar um protocolo de desenvolvimento sadio para a aplicação do futebol no ensino médio. Métodos: Este artigo utilizou a revisão bibliográfica entre outros métodos de investigação. A análise foi dedicada ao treino aeróbico para a resistência no futebol dos estudantes no ensino médio. Estudou-se os métodos específicos de implementação do protocolo elaborado nas escolas de ensino médio. Finalmente, foram apresentadas as medidas eficazes para melhorar a condição física dos estudantes. Resultados: A julgar pela situação em tela, a duração de cada sessão de treino no futebol do ensino médio está intimamente relacionada com a capacidade dos treinadores. Os treinadores de alto nível tendem a organizar a duração do treino de acordo com os efeitos perceptíveis na prática do futebol, considerando as características físicas e técnicas do próprio esporte. Conclusão: A formação de resistência no futebol pode também promover o desenvolvimento a longo prazo da educação futebolística ao mesmo tempo em que satisfaz as necessidades reais de exercício físico dos estudantes, sendo de grande importância realizar a formação do treino aeróbico no futebol aplicado ao ensino médio. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.

RESUMEN Introducción: La fatiga perjudica la actividad del ejercicio en los estudiantes de secundaria, y es perjudicial explorar el entrenamiento aeróbico cuando la fatiga no se puede aliviar. Este factor limita la capacidad de explotar el máximo potencial de los jóvenes deportistas para el fútbol. Objetivo: Implementar un protocolo de desarrollo saludable para la aplicación del fútbol en la escuela secundaria. Métodos: Este artículo utilizó, entre otros métodos de investigación, la revisión de la literatura. El análisis se dedicó al entrenamiento aeróbico de resistencia en el fútbol para estudiantes de secundaria. Se estudiaron los métodos específicos de aplicación del protocolo elaborado en los institutos. Por último, se presentaron las medidas eficaces para mejorar la aptitud física de los alumnos. Resultados: A juzgar por la situación en la pantalla, la duración de cada sesión de entrenamiento en el fútbol de la escuela secundaria está estrechamente relacionada con la capacidad de los entrenadores. Los entrenadores de alto nivel tienden a organizar la duración del entrenamiento en función de los efectos percibidos en la práctica del fútbol, teniendo en cuenta las características físicas y técnicas del propio deporte. Conclusión: El entrenamiento de la resistencia en el fútbol también puede promover el desarrollo a largo plazo de la educación futbolística al tiempo que satisface las necesidades reales de ejercicio físico de los estudiantes, y es de gran importancia llevar a cabo la formación del entrenamiento aeróbico en el fútbol aplicado a la escuela secundaria. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.

A deep learning-based approach toward differentiating scalp psoriasis and seborrheic dermatitis from dermoscopic images.

Objectives: This study aims to develop a new diagnostic method for discriminating scalp psoriasis and seborrheic dermatitis based on a deep learning (DL) model, which uses the dermatoscopic image as input and achieved higher accuracy than dermatologists trained with dermoscopy. Methods: A total of 1,358 pictures (obtained from 617 patients) with pathological and diagnostic confirmed skin diseases (508 psoriases, 850 seborrheic dermatitides) were randomly allocated into the training, validation, and testing datasets (1,088/134/136) in this study. A DL model concerning dermatoscopic images was established using the transfer learning technique and trained for diagnosing two diseases. Results: The developed DL model exhibits good sensitivity, specificity, and Area Under Curve (AUC) (96.1, 88.2, and 0.922%, respectively), it outperformed all dermatologists in the diagnosis of scalp psoriasis and seborrheic dermatitis when compared to five dermatologists with various levels of experience. Furthermore, non-proficient doctors with the assistance of the DL model can achieve comparable diagnostic performance to dermatologists proficient in dermoscopy. One dermatology graduate student and two general practitioners significantly improved their diagnostic performance, where their AUC values increased from 0.600, 0.537, and 0.575 to 0.849, 0.778, and 0.788, respectively, and their diagnosis consistency was also improved as the kappa values went from 0.191, 0.071, and 0.143 to 0.679, 0.550, and 0.568, respectively. DL enjoys favorable computational efficiency and requires few computational resources, making it easy to deploy in hospitals. Conclusions: The developed DL model has favorable performance in discriminating two skin diseases and can improve the diagnosis, clinical decision-making, and treatment of dermatologists in primary hospitals.

Research progress of the orexinergic system in migraine attack generation / 中华神经科杂志

Migraine is a complex disorder of brain function. The hypothalamus has been identified to play a crucial role in attack generation and secretes various neuropeptides. The orexinergic system plays a role in energy metabolism, arousal, sleep, stress and pain modulation. These disorders are closely related to clinical symptoms of migraine. Therefore, the study of the mechanism of hypothalamic orexinergic system in migraine may provide a new perspective for treatment. This article discusses the relationship between hypothalamic orexin system and migraine premonitory symptoms, and briefly summarizes the possible role and mechanism of hypothalamic orexin system in migraine.

Clinical practice of percutaneous full-endoscopic modified posterior lumbar interbody fusion combined with pedicle screw fixation through paraspinal muscle clearance / 西安交通大学学报(医学版)

【Objective】 To study the clinical practice and early outcome of percutaneous full-endoscopic modified posterior lumbar interbody fusion（mPLIF）combined with pedicle screw fixation through paraspinal muscle clearance. 【Methods】 A retrospective study was conducted to analyze the clinical data of patients with lower lumbar spinal diseases treated from May 2019 to April 2020. All the enrolled patients received mPLIF combined with pedicle screw fixation through paraspinal muscle clearance. The follow-up period was more than 1 year； the general parameters included age， gender， duration of disease， diagnosis of disease， surgery segment， and postoperative hospitalization time. Operation parameters included operation time and blood loss. We obtained the clinical parameters such as visual analogue scale （VAS） score for back and lower extremity， Oswestry disability index （ODI） score， and Macnab satisfaction score at the last follow-up. We evaluated the imaging parameters including intervertebral disc height， segmental lordosis angle， lumbar lordosis angle， as well as fusion outcome of patients with single segmental lumbar disease. In addition， intraoperative and postoperative complications were recorded. 【Results】 Totally 18 patients met the inclusion criteria， among whom 8 were male and 10 were female， with the average age of （53.3±8.3） years old and the average duration of disease being （28.9±36.6） months. Among them 16 patients were diagnosed as lumbar degenerative disease and the other 2 had lumbar disc infection. One patient received L3-L4 and L4-L5 intervertebral fusion； the others had one-segmental fusion， among which 11 cases were L4-L5 and 6 cases were L5-S1. The average operation time was （207.8±31.7） min， and the average blood loss was （25.6±7.8） mL， and the mean postoperative hospitalization time was （6.56±2.30） days. VAS scores of back and lower extremities at postoperative 1 week， 6 months and the last follow-up were statistically significantly improved from the preoperative scores. ODI scores at postoperative 6 months and the last follow-up were also statistically significantly improved. The rate of excellent and good according to the Macnab criteria was 94.4%. For the 17 single-level fusion patients， intervertebral height was significantly higher postoperatively and at the last follow-up compared with that of the preoperative one （P<0.05）. Segmental lordosis angle was bigger postoperatively and at the last follow-up （P>0.05）， which was not statistically significant. Lumbar lordosis angle was significantly bigger postoperatively （P<0.05） and bigger at the last follow-up， but with no statistical significance （P>0.05）. The fusion rate at the last follow-up was 88.2%. The cage broke in the process of implantation in one patient. A cage retroposition occurred in one patient at the follow-up. 【Conclusion】 Percutaneous full-endoscopic modified posterior lumbar interbody fusion combined with pedicle screw fixation through bilateral paraspinal muscle clearance by one incision showed excellent clinical outcomes in treating many kinds of lower lumbar diseases. This operation should be an excellent option for lower lumbar fusion.

Primary screening of children with vaccination contraindications and referral recommendations: suggestions for primary care of children in Shenzhen / 中华实用儿科临床杂志

Guideline or consensus for the vaccination of children with special conditions like immunocompromised children may be more suitable for pediatricians.However, the vaccination of children in China is mainly performed by general practitioners or child health care practitioners in community health service centers.They need to master the screening knowledge of contraindications and precautions for the vaccination of children, and make the decision to referral to specialists.Based on the technical guidelines for Immunization of National Health Commission of the People′s Republic of China, Best Practices Guidance of the Advisory Committee on Immunization Practices and contraindications and precautions proposed by the Immunization Action Coalition, 20 suggestions for primary screening of children with vaccination contraindications and referral recommendations for primary care providers were developed by experts from the Integration of Medicine and Prevention in Children of Health Commission of Shenzhen Municipality.

Effects of low level of calcium on the biological behavior of rat primary ameloblasts cultured in vitro / 西安交通大学学报(医学版)

【Objective】 To explore the effect of low levels of calcium on the biological characteristics of ameloblasts. 【Methods】 Rat primary ameloblasts were cultured in standard DMEM medium. After five days they were identified by RT-PCR and immunohistochemistry. Then 0, 0.6 and 1.2 mmoL/L Ca2+ and 100 mL/L fetal bovine serum were added into DMEM medium without calcium. After 48 hours, the cell morphology was observed by inverted microscope. The proliferation and apoptosis of cells were separately examined by MTT and AnnexinV-PI. Real-time quantitative PCR was used to detect the expression levels of amelogenin and KLK4 mRNA. 【Results】 After Five days in standard DMEM medium, the cells were shaped like the paving pattern. RT-PCR showed that both amelogenin and KLK4 were expressed in the cells. Immunohistochemical staining showed that most cells had positive staining for amelogenin. After 48 hours of calcium intervention, some cells in 1.2 mmoL/L Ca2+ group had higher nuclear density and poor light transmittance, and more high columnar cells could be observed in 1.2 mmoL/L Ca2+ group than those in 0 and 0.6 mmoL/L Ca2+ groups. With the decrease in calcium concentration in the medium, MTT showed that the proliferation activity of ameloblasts reduced (P<0.01). Annexin V-PI showed that the percentage of apoptotic cells decreased, and there was a significant difference between 1.2 mmoL/L and 0 mmoL/L Ca2+ groups (P<0.05). Real time-PCR showed that the expressions of amelogenin and KLK4 mRNA reduced (P<0.01). 【Conclusion】 Low-level calcium may inhibit the differentiation of ameloblasts, thereby affecting the formation of enamel mineralization.

Application of blood lactate level in evaluating the prognosis of liver failure patients / 临床肝胆病杂志

As lactate is elevated due to lactate metabolic disorder in liver failure, recent studies have shown that blood lactate has a high value in predicting the prognosis of liver failure. With reference to the research findings in recent years, this article introduces the prediction model of LiFe score and reviews the advances in the clinical application of blood lactate level in patients with liver failure in China and foreign countries. It is believed that a high lactate level is an independent risk factor for poor prognosis of liver failure patients, and it is proposed that lactate can be used as an important indicator to evaluate the severity and prognosis of liver failure and further optimize the scoring system for the prognosis of related liver diseases.

Effect of different structural parameters of filter rod on mechanical properties of new vena cava filter / 生物医学工程学杂志

The dynamic analysis of the implantation process of a new vena cava filter was carried out by finite element analysis method to reveal the influence of the angle, length, width and thickness of the filter rod on its mechanical properties and the inner wall of the blood vessel. The results showed that the high-stress and high-strain areas of the filter were mainly concentrated in the connection between the filter rod and the filter wire. With the increase of the angle of the filter rod, the maximum equivalent stress and the maximum elastic strain on the filter wall decreased, while the maximum equivalent stress on the vascular wall increased. With the increase of the length of the filter rod, the maximum equivalent stress and strain peak of the filter wall increased, but the maximum equivalent stress of the vessel wall decreased. With the increase of the width and thickness of the filter rod, the maximum equivalent stress of the filter wall, the maximum elastic strain and the maximum equivalent stress of the vessel wall all showed an upward trend. The static safety factor of all filter models was greater than 1, and the structure after implantation was safe and reliable. The results of this study are expected to provide a theoretical basis for the structural optimization and deformation mechanism of the new type vena cava filter.

The pathological characteristics and outcomes of 40 surgically treated stage M1b non-small cell lung cancer patients / 中华肿瘤杂志

Objective@#Clinical evidences of surgically treated stage M1b non-small cell lung cancer (NSCLC) patients were limited. This study aimed to summarize the clinical data of these patients to explore the prognostic factors of this population.@*Methods@#From January 1999 to December 2012, the clinical data of 40 stage M1b NSCLC patients, including 24 males and 16 females, who underwent surgery were collected by Cancer Hospital, Chinese Academy of Medical Sciences. Kaplan-Meier method, log rank test and Cox risk regression model were used to analyze the prognose of these patients and their influence factors.@*Results@#A total of 40 patients were available for survival analysis. The Survival rates of the whole population at 1, 3 and 5 years were 70.0%, 40.0% and 22.5%, respectively. The median survival time (MST) was 31.5 months. The outcomes of 23 patients underwent primary tumor resection and local treatment of metastatic site (MST: 41.5 months) were significantly better than those of 13 patients with only primary tumor resection (MST: 15.5 months) and 4 patients with thoracic exploration (MST: 14.5 months) (P<0.05). Multivariate analysis showed that patients without pleural effusion, brain metastasis, chemotherapy and targeted therapy had a statistically better survival (P<0.05).@*Conclusions@#The overall survivals of surgically treated stage M1b NSCLC patients appear encouraging, and some selected patients may even achieve a long-time survival. Multimodality treatment including surgical lung resection and radical treatment of metastasis should be considered for these patients.

Study on mechanical properties of nitinol iliac vein stent and animal test under different release scales / 生物医学工程学杂志

The mechanical properties of nitinol iliac vein stent (NIVS) have been studied by many scholars at home and abroad, but the study on the mechanical properties of iliac vein stent under different release scales has not been reported yet. Based on the finite element analysis method, the mechanical properties of three self-developed NIVS were studied to reveal the influence of stent diameters (12, 14, 16 mm) and different release scales (80%, 90%) on its strength, fatigue life and vein wall biomechanical properties. With an increases in the release scales, the equivalent elastic strain, fatigue strength safety factors, and vessel wall equivalent stress exhibited a downward trend, while the most stressed cross-section coincided with the arc of stent-connecting rods. Through 30, 60 and 90 days' animal test, a narrowed vascular model was established in the iliac veins of 12 pigs, and the developed iliac vein stents were implanted to comprehensively evaluate the safety and effectiveness of the stent, and at the same time the mechanical properties of stents were verified to provide important reference for the type inspection and clinical trials of follow-up products.

Hemodynamic analysis of a new retrievable vena cava filter / 生物医学工程学杂志

Vena cava filter is a filter device designed to prevent pulmonary embolism caused by thrombus detached from lower limbs and pelvis. A new retrievable vena cava filter was designed in this study. To evaluate hemodynamic performance and thrombus capture efficiency after transplanting vena cava filter, numerical simulation of computational fluid dynamics was used to simulate hemodynamics and compare it with the commercialized Denali and Aegisy filters, and in vitro experimental test was performed to compare the thrombus capture effect. In this paper, the two-phase flow model of computational fluid dynamics software was used to analyze the outlet blood flow velocity, inlet-outlet pressure difference, wall shear stress on the wall of the filter, the area ratio of the high and low wall shear stress area and thrombus capture efficiency when the thrombus diameter was 5 mm, 10 mm, 15 mm and thrombus content was 10%, 20%, 30%, respectively. Meanwhile, the thrombus capture effects of the above three filters were also compared and evaluated by in vitro experimental data. The results showed that the Denali filter has minimal interference to blood flow after implantation, but has the worst capture effect on 5 mm small diameter thrombus; the Aegisy filter has the best effect on the trapping of thrombus with different diameters and concentrations, but the low wall shear stress area ratio is the largest; the new filter designed in this study has a good filtering and capture efficiency on small-diameter thrombus, and the area ratio of low wall shear stress which is prone to thrombosis is small. The low wall shear stress area of the Denali and Aegisy filters is relatively large, and the risk of thrombosis is high. Based on the above results, it is expected that the new vena cava filter designed in this paper can provide a reference for the design and clinical selection of new filters.

Overall burden of cerebral small vessel disease imaging and stroke outcomes / 国际脑血管病杂志

Cerebral small vessel disease (CSVD) is an imaging and clinical syndrome caused by intracranial small vessel lesions.Studies have confirmed that CSVD is closely associated with the stroke outcomes.The overall burden is a concept based on a single imaging marker of CSVD,which can comprehensively reflect the severity of brain injury and identify high-risk stroke patients.This article reviews the correlation between the overall burden of the CSVD imaging and the stroke outcomes.

Ulinastatin can reduce the inflammation response after laparoscopic colectomy:a propensity score match-ing study / 实用医学杂志

Objective To investigate the effect of ulinastatin on postoperative clinical outcomes in pa-tients undergoing elective laparoscopic colectomy. Methods 454 patients underwent elective laparoscopic colecto-my from January 2015 to September 2017 were included in this retrospective study. Patients were divided into 2 groups:ulinastatin group and control group. Propensity score matching was applied to balance the preoperative baseline differences between 2 groups. 155 patients in each group were successfully matched. Mixed linear model was used to exam the effect of ulinastatin on various clinical indicators within 3 days after the surgery,including in-flammation indicators(white blood cell counts,C reactive protein),liver function indicators(alanine transami-nase,aspartate transaminase,total bilirubin),renal function indicators(serum creatinine,blood urea nitrogen). Postoperative hospital length of stay was compared between 2 groups using student's t-test. Results Ulinastatin group showed significantly reduced postoperative white blood cell count and ? reactive protein level (P = 0.036 and 0.025)compared with the control group. The average mean inhibitory effects were 1.04×109/L and 23.93 mg/L respectively,which was 11.1% and 29.9% lower than that of the control group. Procalcitonin,transaminases,total bilirubin,serum creatinine,blood urea nitrogen levels and postoperative hospital length of stay showed no signifi-cant difference between the two groups(P > 0.05). Conclusion Ulinastatin can significantly reduce the level of inflammation response after laparoscopic colectomy,which is beneficial to the fast recovery.

The effect of spinal sagittal balance on secondary fracture after percutaneous kyphoplasty for osteoporotic vertebral compression fractures / 中华创伤骨科杂志

Objective To explore the effect of spinal sagittal balance on secondary vertebral fracture after percutaneous kyphoplasty (PKP) for osteoporotic vertebral compression fractures (OVCF).Methods The data were reviewed of the patients with single segmental OVCF who had undergone PKP at Department of Spine Surgery,Second Hospital of Lanzhou University from March 2014 to December 2015.Of them,21 had secondary vertebral fracture after PKP.As an observational group,they were matched with another 21 patients without secondary vertebral fracture after PKP as a control group (ratio:1:1) for age,gender,body mass index (BMI) and bone mineral density (BMD).Their standard standing plain radiographs of the whole spine were used to measure the parameters of spine-pelvis sagittal balance.The 2 groups were compared in sagittal balance parameters.Results The sagittal vertical axis (26.86 ± 33.55 mm) and thoracic kyphosis (47.62° ± 10.73°) in the observational group were significantly larger than those (4.05 ± 31.93 mm and 41.10 °±8.17°) in the control group (P ＜0.05);the lumbar lordosis (35.29°±8.77 °),sacral slope (22.71 ° ± 5.80°) and pelvic incidence (45.38° ± 7.49°) in the former were significantly smaller than those in the control group (41.71°±9.19°,27.43°±5.29° and 51.19°±8.44°) (P ＜0.05);there were no significant differences between the 2 groups in pelvic tilt or thoracolumbar kyphosis (P ＞ 0.05).Conclusions The OVCF patients with larger sagittal vertical axis,larger thoracic kyphosis and smaller lumbar lordosis may be more likely to suffer secondary vertebral fracture after PKP.A larger pelvic incidence may be a protective factor against secondary vertebral fracture after PKP for OVCF patients.

Clinical validation of pinopode as a marker of endometrial receptivity: a randomized controlled trial.

OBJECTIVE: To determine the clinical value of pinopodes in the human. DESIGN: Randomized controlled trial. SETTING: Academic fertility center. PATIENT(S): From December 2014 to December 2016, in a phase I trial, 363 patients were recruited in their first IVF cycles. In a phase II trial, 136 patients with at least two previous embryo implantation failures were recruited. INTERVENTION(S): In the phase I trial, in the midluteal phase, endometrial tissues were obtained for scanning electron microscopy, and their IVF treatment outcomes were followed up. In the phase II trial, participants were allocated into two groups by random number table, and the experimental group had twice the number of the control group. Individual ETs (iETs) were performed in the experimental group, while frozen-thawed embryos were routinely transferred in the control group. MAIN OUTCOME MEASURE(S): Clinical pregnancy rate (CPR) and ongoing pregnancy rate (OPR). RESULT(S): In the phase I trial, through receiver operation characteristic curve analysis, the optimal pinopode scoring for successful clinical pregnancy was determined to be 85. The CPR (74.29% vs. 19.77%) and OPR (62.86% vs 11.86%) were significantly higher in the patients whose pinopode scoring was >85. In the phase II trial, the CPR was dramatically higher in the iET group (33.82% vs. 8.11%). CONCLUSION(S): Pinopode scoring is a reliable marker of endometrial receptivity, and iET based on pinopode scoring is a promising solution for recurrent implantation failure. TRIAL REGISTRATION NUMBERS: ChiCTR-OOC-14005617; ChiCTR-OOC-15005882.

Effectiveness of tyrosine kinase inhibitors against non-small cell lung cancer patients with postoperative recurrence harboring uncommon EGFR mutations / 中华肿瘤杂志

Objective@#To investigate the efficacy of tyrosine kinase inhibitor (TKI) treatment on non-small cell lung cancer (NSCLC) patients with postoperative recurrence who harbored uncommon EGFR mutations, and discuss the relationship between TKI treatment and prognosis.@*Methods@#A total of 39 relapsed NSCLC patients after surgery with EGFR uncommon mutations who were detected at Cancer Hospital, Chinese Academy of Medical Sciences between January 1999 and December 2013 were retrospectively analyzed in this study. Twenty patients were treated with EGFR-TKI after recurrence and 19 cases were not. The clinical characteristics of patients with EGFR uncommon mutations were evaluated, and the prognosis of TKI-treatment group and non-TKI treatment group was compared.@*Results@#In 39 relapsed NSCLC patients with EGFR uncommon mutations, insertion mutations and point mutations were included. The highest frequency of EGFR uncommon mutation happened in exon 20 (20/39, 51.3%). A total of 13 uncommon point mutations were detected in exon 18, 20 and 21. The most frequent rare point mutations located in exon 21, and there were 7 different point mutation sites in exon 21. G719S/C/A mutation in exon 18 was the most common type of point mutation (14/25, 56.0%). Survival after postoperative recurrence in TKI treatment group was obviously better than that in non-TKI treatment group, the median time after recurrence were 44 months and 23 months, respectively (P=0.044). However, the postoperative overall survival showed no differences between two groups (48 months vs 43 months, P=0.129).@*Conclusion@#NSCLC patients with postoperative recurrence who harbored rare EGFR mutations should be treated with TKI agent.