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Ai Zheng ; 22(2): 178-84, 2003 Feb.
Artículo en Chino | MEDLINE | ID: mdl-12600296

RESUMEN

BACKGROUND & OBJECTIVE: Matrix metalloproteinase-9 (MMP-9) might plays an important role in regulating processes of tumor angiogenesis, invasion,and metastasis. The expression and clinical significance of MMP-9 in early invasive carcinoma of cervix was investigated. METHODS: Expression of MMP-9, microvessel density (MVD) labeled by CD(34) and proliferation index of cancer cells labeled by Ki-67 in 75 cases of early invasive carcinoma of cervix (ICC), 18 cases of cervical intraepithelial neoplasm (CIN), and 15 cases of normal cervical epithelium (NCE) were detected by immunohistochemistry SP method. RESULTS: MMP-9 was mainly expressed in the cellular membrane and/or cytoplasm in tumor cells,whereas expression of Ki-67 was mainly confined to the nuclei, and that of CD(34), to the vascular epithelial cells in tumor stroma. It was shown that positive rate of expression of MMP-9,Ki-67, and MVD increased remarkably from NCE to CIN,and then to ICC accordingly(P< 0.05). In ICC, MVD was positively related to the expression of MMP-9 (r=0.287, P<0.05). The expression of MMP-9 correlated with pelvic lymph node metastasis, intravascular and stromal infiltration, FIGO staging, histological grading,and Ki-67 expression (P< 0.05 or P< 0.01); but not correlated with patients age and histological types (P >0.05). In cases with pelvic lymph node metastasis, intravascular and deeper stroma infiltration, FIGO staging II, histological grade III and over-expression of Ki-67, positive rate of expression of MMP-9 was significantly higher than that in those without the conditions mentioned above (P< 0.05). CONCLUSION: In cervical carcinoma, MMP-9 may play an important role during tumor angiogenesis, proliferation of cancer cells, cancer invasion and metastasis. Over-expression of MMP-9 may result in great increase of tumor angiogenesis, rapid proliferation of cancer cells, cancer invasion and metastasis, but it is not the only decisive factor. Detection expression of MMP-9 may be of value in further understanding the biological behavior and predicting the prognosis of cervical carcinoma.


Asunto(s)
Metaloproteinasa 9 de la Matriz/metabolismo , Neovascularización Patológica/enzimología , Neoplasias del Cuello Uterino/enzimología , Adulto , Anciano , División Celular/fisiología , Femenino , Humanos , Antígeno Ki-67/metabolismo , Metaloproteinasa 9 de la Matriz/fisiología , Persona de Mediana Edad , Invasividad Neoplásica , Metástasis de la Neoplasia/patología , Neoplasias del Cuello Uterino/metabolismo , Neoplasias del Cuello Uterino/patología
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