Microbial fuel cell as power supply for implantable medical devices: a novel configuration design for simulating colonic environment.

This study focused on providing power for implantable medical devices (IMDs) using a microbial fuel cell (MFC) implanted in human transverse colon. Considering the condition of colonic environment, a continuous-flow single-chamber MFC without membrane was set up. The performance of the MFC was investigated. The power output of 1.6 mW under the steady state was not rich enough for some high energy-consuming IMDs. Moreover, the parameters of the simulated colonic environment, such as pH and ORP value, varied along with the time. Hence, a new MFC configuration was developed. In this novel model, pH transducers were placed in cathodic and anodic areas, so as to regulate the reactor operation timely via external intervention. And two ORP transducers were inserted next to the pH transducers, for monitoring and adjusting the MFC operation efficiently. Besides, colonic haustra were designed in order to increase the difference between cathodic and anodic areas.

A microbial fuel cell as power supply for implantable medical devices.

This study seeks a new way to provide lasting and secure power for implantable medical devices (IMDs) using a microbial fuel cell (MFC) which was proposed to be placed in human large intestine and could utilize intestinal contents and microorganisms to generate electricity. Based on the anatomic structure and inner environmental conditions of large intestine, transverse colon was chosen to be the appropriate location for the implantation of MFC. The performance of the MFC which simulated the environmental features of transverse colon by controlling dissolved oxygen (DO) and pH and was inoculated with simulated intestinal fluid (SIF) was investigated. Stable power generation of MFC was obtained after two months operation with open circuit voltage (OCV) of 552.2 mV, maximum power density of 73.3 mW/m(2), and average voltage output of 308 mV (with external resistance of 500 Omega). Moreover, the changes of environmental conditions in the chambers of MFC did not have a significant impact on human body based on the analysis of pH and DO values. Further studies on internal resistance and power density showed that the MFC could generate power of 7-10 mW according to the size of intestinal surface area, which was enough for IMDs. These results suggested that MFCs located in large intestine could be a promising power source for IMDs.