1.
Org Lett
; 26(28): 6041-6046, 2024 Jul 19.
Artículo
en Inglés
| MEDLINE
| ID: mdl-38973673
RESUMEN
A hypervalent iodine-mediated intermolecular α-umpolung reaction between α-aryl- or alkyl-substituted amides and benzotriazoles or purine derivatives as N-centered nucleophiles has been established. The reaction involves sequential intra/intermolecular oxidative C-N couplings in a controlled manner, affording tetrasubstituted 3,3'-oxindoles in moderate to good yields. This approach efficiently addresses the challenges in constructing tetrasubstituted carbon centers via α-umpolung functionalizations of carbonyl compounds and serves as a new strategy for synthesizing biologically important 3,3'-disubstituted oxindoles.