[Expressing foreign genes by Newcastle disease virus for cancer therapy].

An interesting aspect of Newcastle disease virus (NDV) is the ability to selectively replicate in tumor cells. Recently, using reverse genetics technology to enhance the oncolytic properties and therapeutic potential of NDV for tumor therapy has become popular in immunocompetent carcinoma tumor models. Expressing foreign genes by recombinant NDV (rNDV-FG) has been shown to be more effective in cancer therapy in preclinical studies. This paper provides an overview of the current studies on the cytotoxic and anti-cancer effects of rNDV-FG via direct oncolysis and immune stimulation. Safety of rNDV-FG as a therapeutic agent for cancer immunotherapy and virotherapy is also discussed.

Analysis of factors influencing safety management for metro construction in China.

With the rapid development of urbanization in China, the number and size of metro construction projects are increasing quickly. At the same time, and increasing number of accidents in metro construction make it a disturbing focus of social attention. In order to improve safety management in metro construction, an investigation of the participants' perspectives on safety factors in China metro construction has been conducted to identify the key safety factors, and their ranking consistency among the main participants, including clients, consultants, designers, contractors and supervisors. The result of factor analysis indicates that there are five key factors which influence the safety of metro construction including safety attitude, construction site safety, government supervision, market restrictions and task unpredictability. In addition, ANOVA and Spearman rank correlation coefficients were performed to test the consistency of the means rating and the ranking of safety factors. The results indicated that the main participants have significant disagreement about the importance of safety factors on more than half of the items. Suggestions and recommendations on practical countermeasures to improve metro construction safety management in China are proposed.

Activity and radiation protection studies for the W-Ta target of CSNS.

The Chinese government initiated a conceptual design for the project of China Spallation Neutron Source (CSNS), which consists of an H-linear accelerator, a rapid cycling synchrotron accelerating the beam to 1.6 GeV, a target station converting proton beam into lower energy (<1 eV) neutron beam optimised to instruments for neutron scattering applications. The facility operates at 25-Hz repetition rate with an initial beam power of 100 kW. In the target station, the target-moderator-reflector (TMR) components are exposed to the intensive fluxes of high-energy hadrons and become highly radioactive as a result of long-time irradiation. In this paper, the activity of the TMR components are calculated using the Monte Carlo code system LAHET&MCNP4C&CINDER'90. Comparisons of some results with that simulated by FLUKA code are also performed. Detailed analyses of the radionuclides and their characters in the tantalum clad tungsten target (W-Ta target) are important for the radiation protection of the CSNS target station. The shielding design of the service cell for the decay gamma ray induced from the W-Ta target and its vessel shows that the ambient dose rate decreases exponentially with increasing heavy concrete thickness. And 80 cm thickness of heavy concrete for each side of the service cell can satisfy the safety requirement.

Effective fast electron acceleration along the target surface.

The dependence of angular distributions of fast electrons generated in the interaction of p-polarized femtosecond laser pulses with foil targets on laser intensities is investigated. A novel fast electron beam along the front target surface is observed for high laser intensity. It is found that the electron acceleration along the target surface is more efficient than those in other directions.

Effect of target shape on fast electron emission in femtosecond laser-plasma interactions.

Fast electron emission from the interaction of femtosecond laser pulses with shaped solid targets has been studied. It is found that the angular distributions of the forward fast electrons are highly dependent upon the target shapes. The important roles played by the electrostatic fields built up at the non-laser-irradiated target surfaces and the collisions in the target are identified. Our two-dimensional particle-in-cell simulations with binary collisions included reproduce the main experimental observations.

Oval-like hollow intensity distribution of tightly focused femtosecond laser pulses in air.

The propagation of a tightly focused femtosecond laser pulse in air has been investigated. Unlike long-distance self-guided propagation of short laser pulses, a novel oval-like hollow distribution of the laser intensity is observed in the experiments and reproduced by the numerical simulations. The formation of the hollow structures can be explained by the interplay between ionization-induced refraction and Kerr self-focusing.

Observation of a fast electron beam emitted along the surface of a target irradiated by intense femtosecond laser pulses.

A novel fast electron beam emitting along the surface of a target irradiated by intense laser pulses is observed. The beam is found to appear only when the plasma density scale length is small. Numerical simulations reveal that the electron beam is formed due to the confinement of the surface quasistatic electromagnetic fields. The results are of interest for potential applications of fast electron beams and deep understanding of the cone-target physics in the fast ignition related experiments.

Thomson scattering measurements of heat flux from ion-acoustic waves in laser-produced aluminum plasmas.

Thomson scattering (TS) measurements are performed at different locations in a laser-produced aluminum plasma. Variations of the separation, wavelength shift, and asymmetric distribution of the two ion-acoustic waves are investigated from their spectral-time-resolved TS images. Detailed information on the space-time evolution of the plasma parameters is obtained. Electron distribution and variation of the heat flux in the plasma are also obtained for a steep temperature gradient.

Energetic electrons emitted from ethanol droplets irradiated by femtosecond laser pulses.

We investigate the angular distribution and the energy spectrum of hot electrons emitted from ethanol droplets irradiated by linearly polarized 150-fs laser pulses at an intensity of 10(16) W/cm(2). Two hot electron jets symmetrically with respect to the laser propagation direction are observed within the polarization plane. This is due to the spherical geometry of droplets in the intense laser field. The maximum energy of the hot electrons is found to be more than 600 keV. Particle-in-cell simulations suggest that the resonance absorption is the main mechanism for hot electron generation.

Blast waves produced by interactions of femtosecond laser pulses with water.

The behaviors of the blast waves produced by femtosecond laser-water interactions, and the blast waves induced by laser self-focusing in air, have been investigated using optical shadowgraphy at a maximum intensity of 1 x 10(16) W/cm(2). The temporal evolution of the blast wave launched by the water plasma can be described by a planar blast wave model including source mass. An aneurismlike structure, due to the quick propagation inside a hollow channel formed by laser self-focusing, is observed. The expansion of the channel in air is found to agree with a cylindrical self-similar blast wave solution.

[Autoimmune hemolytic anemia: clinical analysis of 100 cases].

In 100 cases with autoimmune hemolytic anemia, Coombs test was directly positive in 77 cases (77%). 82 patients had warm autoantibodies. IgM was increased in 12 patients. 3 patients were diagnosed as lymphoma with titers more than 1:1024. One patient had paroxysmal cold hemoglobinuria. The dramatic clinical response to corticosteroid therapy was observed in patients with warm autoantibodies. However, immunosuppressor should be given to patients with cold autoantibodies. It was suggested that combined therapy with two drugs may be more effective than the use of corticosteroid alone. Of 6 patients in whom splenectomy was performed, 4 showed excellent results. Out of 100 cases, there were 23 with Evans syndrome.