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@#To investigate the correlation between plasma D-dimer and subtype，severity and functional prognosis of patients with acute ischemic stroke. Methods The clinical，imaging and laboratory data of patients with acute ischemic stroke were confirmed by clinical and imaging in Peking Union Medical College Hospital from January 2013 to December 2020 were analyzed retrospectively. Results There were 1034 patients with acute ischemic stroke confirmed by clinical and imaging，of which 845 patients completed the detection of plasma D-dimer level within 24 hours and were included in this study. Plasma D-dimer levels was significantly different in different stroke subtypes （P<0.001）. Plasma D-dimer levels was positively correlated with NIHSS score （r=0.166，P<0.001） and mRS score （r=0.125，P<0.001）. Binary regression analysis showed that plasma D-dimer level was associated with poor functional prognosis （unadjusted OR=1.058，95%CI 1.019～1.099；adjusted model 1 OR=1.026，95%CI 1.014～1.091；adjusted model 2 OR=1.022，95%CI 0.984～1.061）. NIHSS score played a full mediation effect between plasma D-dimer level and poor functional prognosis. The sensitivity of plasma D-dimer levels in predicting the prognosis of poor functional prognosis was 54.9%，the specificity was 66.1%，and the area under the receiver operating characteristic （ROC） curve was 0.609.Conclusion We had shown that plasma D-dimer levels are significantly correlated with the etiological classification and severity of acute ischemic stroke，and plasma D-dimer levels may affect the functional prognosis through this correlation. In addition，plasma D-dimer levels can be used to predict poor functional prognosis of acute ischemic stroke.
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Objective The aim of this study was to establish a reasonable protocol for a rat model of ferric chloride-induced carotid arterial thrombosis by ultrasonic continuous evaluation.Methods Twenty SD rats were randomly divided into four groups and then treated with 20％,30％,40％ or 50％ concentrations of FeCl3,respectively.The vascular conditions were evaluated by 14L ultrasonic probe,at 10 mins,15 mins,and 20 mins.We then selected the best group through the examination of the rate of spontaneous reperfusion of blood vessels and the rate of reperfusion after intravenous injection of urokinase.At the end of the experiment,vessels were fixed in 10％ formalin solution and stained with HE.Results After external application of FeCl3 on rat common carotid artery for 20 mins,the artery occlusion rate was 100％,20％,0％ and 0％ in animals receiving 50％,40％,30％ and 20％ FeCl3,respectively.After external application of FeCl3 on rat common carotid artery for 120 mins,the spontaneous revascularization rate was 0％ in 50％ concentration group whereas were 100％ in rest other groups (P＜ 0.001).In 50％ concentration group,the partial recanalization rate was 40％ after intravenous injection of urokinase.HE staining revealed that the thrombus was dense and the lumen was partially recanalized after the urokinase intervention in 50％ concentration group.Conclusion By use of uultrasonic continuous evaluation of ferric chloride-induced thrombosis of rat common carotid artery,we have demonstrated that external application of 50％ ferric chloride solution for 20 mins is effective for the formation of thrombus model,which may be suitable for the studv of thrombolysis.
