RESUMEN
Medication during pregnancy is widespread, but there are few reports on its fetal safety. Recent studies suggest that medication during pregnancy can affect fetal morphological and functional development through multiple pathways, multiple organs, and multiple targets. Its mechanisms involve direct ways such as oxidative stress, epigenetic modification, and metabolic activation, and it may also be indirectly caused by placental dysfunction. Further studies have found that medication during pregnancy may also indirectly lead to multi-organ developmental programming, functional homeostasis changes, and susceptibility to related diseases in offspring by inducing fetal intrauterine exposure to too high or too low levels of maternal-derived glucocorticoids. The organ developmental toxicity and programming alterations caused by medication during pregnancy may also have gender differences and multi-generational genetic effects mediated by abnormal epigenetic modification. Combined with the latest research results of our laboratory, this paper reviews the latest research progress on the developmental toxicity and functional programming alterations of multiple organs in offspring induced by medication during pregnancy, which can provide a theoretical and experimental basis for rational medication during pregnancy and effective prevention and treatment of drug-related multiple fetal-originated diseases.
RESUMEN
Ginsenoside Rc,a dammarane-type tetracyclic triterpenoid saponin primarily derived from Panax ginseng,has garnered significant attention due to its diverse pharmacological properties.This review outlined the sources,putative biosynthetic pathways,extraction,and quantification techniques,as well as the pharmacokinetic properties of ginsenoside Rc.Furthermore,this study explored the pharmaco-logical effects of ginsenoside Rc against metabolic syndrome(MetS)across various phenotypes including obesity,diabetes,atherosclerosis,non-alcoholic fatty liver disease,and osteoarthritis.It also highlighted the impact of ginsenoside Rc on multiple associated signaling molecules.In conclusion,the anti-MetS effect of ginsenoside Rc is characterized by its influence on multiple organs,multiple targets,and multiple ways.Although clinical investigations regarding the effects of ginsenoside Rc on MetS are limited,its proven safety and tolerability suggest its potential as an effective treatment option.
RESUMEN
A large-scale CNC boring machine would not be complete without a column. The tortoise shell is chosen as the bionic prototype, and the column structure is optimized using the bionic optimization design approach, using the column of a thg6920 boring machine as the research object. The structural similarity between the completed turtle shell and the boring machine column is 0.796, according to the fuzzy method. The structural optimization and topological optimization of the column imitating turtle shell are carried out with the ANSYS Workbench, and the bionic column model is established, and then the static analysis and modal analysis are carried out. After bionic optimization and topology optimization, the weight of the column is reduced from 87061 kg to 82107 kg, the maximum stress is reduced to 3.8637 MPa, the maximum stress is reduced by 28.9% compared with the original column, and the specific stiffness and specific strength are increased by 20.65% and 29.4%, respectively. The column structure has also achieved good optimization results in stiffness, strength, and stability.
