Investigation of Temperature Variations and Extreme Temperature Differences for the Corrugated Web Steel Beams under Solar Radiation.

Due to the coupling impacts of solar radiation, wind, air temperature and other environmental parameters, the temperature field of steel structures is significantly non-uniform during their construction and service stages. Corrugated web steel beams have gained popularity in structural engineering during the last few decades, while their thermal actions are barely investigated. In this paper, both experimental and numerical investigations were conducted to reveal the non-uniform features and time variation of the corrugated web steel beams under various environmental conditions. The heat-transfer simulation model was established and verified using the experimental temperature data. Both the experiment and simulation results demonstrate that the steel beam has a complicated and non-uniform temperature field. Moreover, 2-year continuous numerical simulations of steel beams' thermal actions regarding eight different cities were carried out to investigate the long-term temperature variations. Finally, based on the long-term simulation results and extreme value analysis (EVA), the representative values of steel beams' daily temperature difference with a 50-year return period were determined. The extreme temperature difference of the steel beam in Harbin reached up to 46.9 °C, while the extreme temperature difference in Haikou was 28.8 °C. The extreme temperature difference is highly associated with the steel beam's location and surrounding climate. Ideally, the outcomes will provide some contributions for the structural design regarding the corrugated web steel beam.

Experimental Study of Flexural Performance of UHPC-NC Laminated Beams Exposed to Fire.

In recent decades, reinforced-concrete bridges have experienced premature deterioration and other problems during service due to severe environmental effects such as fire and corrosion. Previous studies have shown that the use of ultra-high-performance concrete (UHPC) can improve the durability of bridge structures. In this study, four-point bending tests were conducted on twelve UHPC-NC laminated beams with different UHPC-layer heights and at different temperatures in order to evaluate their flexural performance under fire conditions. The test variables were the UHPC heights (20 mm, 50 mm, 80 mm) and temperatures (20 °C, 200 °C, 400 °C, 600 °C), and the effects on the flexural load capacity of UHPC-NC laminated beams under the influence of these factors were investigated. The test results show that the increase in temperature causes the concrete color to change from grayish blue to white and leads to a significant decrease in the flexural load capacity of the stacked beams. The height of the UHPC layer has an important effect on the stiffness of the stacked beams and delays the formation of local cracks, thus improving the durability of the stacked beams.

Gene Characteristics and Prognostic Values of m6A RNA Methylation Regulators in Nonsmall Cell Lung Cancer.

Background: N6-methyladenosine (m6A) is the most common internal modification present in mRNAs and long noncoding RNAs (lncRNAs), associated with tumorigenesis and cancer progression. However, little is known about the roles of m6A and its regulatory genes in nonsmall cell lung cancer (NSCLC). Here, we systematically explored the roles and prognostic significance of m6A-associated regulatory genes in NSCLC. Methods: The copy number variation (CNV), mutation, mRNA expression data, and corresponding clinical pathology information of 1057 NSCLC patients were downloaded from the cancer genome atlas (TCGA) database. The gain and loss levels of CNVs were determined by utilizing segmentation analysis and GISTIC algorithm. The GSEA was conducted to explore the functions related to different levels of m6A regulatory genes. Logrank test was utilized to assess the prognostic significance of m6A-related gene's CNV. Results: The genetic alterations of ten m6A-associated regulators were identified in 102 independent NSCLC samples and significantly related to advanced tumor stage. Deletions or shallow deletions corresponded to lower mRNA expression while copy number gains or amplifications were related to increased mRNA expression of m6A regulatory genes. Survival analysis showed the patients with copy number loss of FTO with worse disease-free survival (DFS) or overall survival (OS). Besides, copy number loss of YTHDC2 was also with poor OS for NSCLC patients. Moreover, high FTO expression was significantly associated with oxidative phosphorylation, translation, and metabolism of mRNA. Conclusion: Our findings provide novel insight for better understanding of the roles of m6A regulators and RNA epigenetic modification in the pathogenesis of NSCLC.