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BACKGROUND: Photoaging, a result of chronic sun exposure, leads to skin damage and pigmentation changes. Traditional treatments may have limitations in high-altitude areas like Yunnan Province. Intradermal Col Ι injections stimulate collagen production, potentially improving skin quality. This study aims to assess the efficacy and safety of this treatment for photoaging. AIM: To evaluate the efficacy and safety of intradermal type Ι collagen (Col Ι) injection for treating photoaging. METHODS: This prospective, self-controlled study investigated the impact of intradermal injections of Col Ι on skin photodamage in 20 patients from the Yunnan Province. Total six treatment sessions were conducted every 4 wk ± 3 d. Before and after each treatment, facial skin characteristics were quantified using a VISIA skin detector. Skin thickness data were assessed using the ultrasound probes of the Dermalab skin detector. The Face-Q scale was used for subjective evaluation of the treatment effect by the patients. RESULTS: The skin thickness of the right cheek consistently increased after each treatment session compared with baseline. The skin thickness of the left cheek significantly increased after the third through sixth treatment sessions compared with baseline. The skin thickness of the right zygomatic region increased after the second to sixth treatment sessions, whereas that of the left zygomatic region showed a significant increase after the fourth through sixth treatment sessions. The skin thickness of both temporal regions significantly increased after the fifth and sixth treatment sessions compared with baseline (P < 0.05). These findings were also supported by skin ultrasound images. The feature count for the red areas and wrinkle feature count decreased following the treatment (P < 0.05). VISIA assessments also revealed a decrease in the red areas after treatment. The Face-Q-Satisfaction with Facial Appearance Overall and Face-Q-Satisfaction with Skin scores significantly increased after each treatment session. The overall appearance of the patients improved after treatment. CONCLUSION: Intradermal Col Ι injection improves photoaging, with higher patient satisfaction and fewer adverse reactions, and could be an effective treatment method for populations residing in high-altitude areas.
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Abiu fruit (Pouteria caimito [Ruiz & Pavon.] Radlk.) is endemic to the Amazonian region of South America, the fruit is also called yellow star apple, blueberry pie fruit and cauje. In this study, the chloroplast genome sequence of P. caimito was assembled and characterized using Illumina sequencing. The whole chloroplast genome of the wild species of abiu fruit is 158,916 bp, composed of four regions: a large single-copy region (88,096 bp) and a small single copy (18,620 bp) region, separated by two inverted repeat regions (26,100 bp), and the GC content is 36.83%. A total of 133 genes were annotated, including 88 that encoded proteins, eight that encoded rRNA genes and 37 that encoded tRNA genes. A maximum likelihood tree was constructed based on the sequences of chloroplast genome, the results showed that the wild species of P. caimito is the most closely related to Pouteria campechiana. This study provided abundant genomics data for the research and development of P. caimito.
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BACKGROUND: At present, the standard method for clinical treatment of bone defects is autologous bone transplantation. However, the source of autologous bone is limited and it can cause new trauma and defects. Therefore, the development of ergonomic tissue-engineered bone has become the trend of repairing bone defects. OBJECTIVE: To summarize the characteristics and manufacturing techniques of collagen/inorganic materials to construct tissue-engineered bone. METHODS: PubMed, Web of Science (January 2000–January 2020) and CNKI (2010–2020) databases were used online to retrieve the relative articles regarding the application of collagen/inorganic composite scaffold. The key words were “collagen; inorganic materials; tissue-engineered bone; bone repair; geometry of bone scaffold” in English and Chinese, respectively. RESULTS AND CONCLUSION: Applying the principle of bionics, collagen composite inorganic materials were used to construct tissue-engineered bones by simulating the composition, structure, and characteristics of natural bones, which is an important direction in the field of bone graft materials. Collagen provides the extracellular matrix effect of the scaffold material, and promotes the migration, adhesion, and proliferation of cells on the scaffold, and accelerates the degradation of the scaffold in the body, and makes the composite scaffold has good biocompatibility and osteoinductivity. Choosing a suitable manufacturing technology to change the geometry of the collagen/inorganic material scaffold, and achieving the best three-dimensional porous nanoscale structure can promote cell adhesion and proliferation, and enhance the bone regeneration capacity of collagen/inorganic material scaffolds. Simultaneously, the surface of collagen/inorganic scaffolds is modified. Stem cells, biological factors, and polymers with osteogenic or angiogenic potential were compounded onto collagen/inorganic material scaffolds, which will improve the poor mechanical properties, insufficient structural stability, and limited bone regeneration capacity of collagen/inorganic material scaffolds. This provides a good idea for the option of tissue-engineered bone graft materials.
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Syzygium malaccense is native to Malaysia. It is sometimes called the malay apple, malay rose-apple, mountain rose-apple, mountain apple, water apple, or French cashew. The tree is very popular in many tropical and subtropical regions for its fruit and traditional medicine. The first complete chloroplast genome of Syzygium malaccense has been reported in this study. The complete chloroplast genome of Syzygium malaccense is 158,954 bp, composed of four regions: a large single-copy region with a size of 87,991 bp, a small single copy region with a size of 18,793 bp, and two inverted repeat regions with a size of 26,085 bp. The GC content is 36.97%. A total of 132 genes were annotated, including 84 encoding proteins, eight encoding rRNA genes, 37 encoding tRNA genes, and three encoding pseudo genes. Phylogenetic analysis showed that Syzygium aromaticum, Syzygium cumini, and Syzygium forrestii are closely related to Syzygium malaccense.
