RESUMEN
The antiviral activity of Escherichia coli-derived (Serine-17) human interferon-beta, formulated with human serum albumin, is stable for 2 years when lyophilized and stored under refrigeration. This product shows an Arrhenius line fit for the stability of its activity when tested at multiple isothermal temperatures (25-80 degrees C). In both isothermal and nonisothermal elevated temperature studies, increasing the level of human serum albumin in the formulation results in increased thermal stability.
Asunto(s)
Interferón Tipo I/farmacología , Interferón beta , Proteínas Recombinantes/farmacología , Virus de la Estomatitis Vesicular Indiana/efectos de los fármacos , Línea Celular , Estabilidad de Medicamentos , Escherichia coli/genética , Humanos , Interferón Tipo I/genética , Interferón beta-1a , Interferon beta-1b , TermodinámicaRESUMEN
The results for the 1978 multidisciplinary education seminars of the American Society for Parenteral and Enteral Nutrition were analyzed. The following aspects were evaluated: attendance, pre- and post-test results, and course evaluations. Data were examined as to combined results (7 seminars) and cohort (2 seminars) analyses. Physicians had the highest mean score on the pretest while nurses showed the most improvement on the post-test. All groups, except the dietitians, rated the seminars as being relatively inappropriate to their clinical practices. The program format and lecture contents were rated to be very good by all groups. Recommendations for future multidisciplinary courses are included.
