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BMC Microbiol ; 22(1): 6, 2022 01 04.
Artículo en Inglés | MEDLINE | ID: mdl-34979901

RESUMEN

BACKGROUND: Aquatic matrices impacted by sewage may shelter carbapenem-resistant (CR) Gram-negative bacilli (GNB) harboring resistance genes of public health concern. In this study, sewage treatment plants (STPs) servicing well-defined catchment areas were surveyed for the presence of CR-GNB bearing carbapenemase genes (blaKPC or blaNDM). RESULTS: A total of 325 CR-GNB were recovered from raw (RS) and treated (TS) sewage samples as well as from water body spots upstream (UW) and downstream (DW) from STPs. Klebsiella-Enterobacter (KE) group amounted to 116 isolates (35.7%). CR-KE isolates were recovered from TS, DW (35.7%) and RS samples (44.2%) (p = 0.001); but not from UW samples. KE isolates represented 65.8% of all blaKPC or blaNDM positive strains. The frequency of blaKPC-or-NDM strains was positively associated with the occurrence of district hospitals located near STPs, as well as with the number of hospitalizations and of sewer connections serviced by the STPs. blaKPC-or-NDM strains were recovered from ST samples in 7 out of 14 STPs, including four tertiary-level STPs; and from 6 out of 13 DW spots whose RS samples also had blaKPC-or-NDM strains. CONCLUSIONS: Clinically relevant GNB bearing blaKPC-or-NDM resist sewage treatments and spread into environmental aquatic matrices mainly from STPs impacted by hospital activities.


Asunto(s)
Proteínas Bacterianas/genética , Carbapenémicos/farmacología , Farmacorresistencia Bacteriana/genética , Bacterias Gramnegativas/aislamiento & purificación , Hospitales de Distrito , Microbiología del Agua , beta-Lactamasas/genética , Brasil , Áreas de Influencia de Salud , Farmacorresistencia Bacteriana/efectos de los fármacos , Monitoreo del Ambiente , Bacterias Gramnegativas/clasificación , Bacterias Gramnegativas/efectos de los fármacos , Bacterias Gramnegativas/genética , Infecciones por Bacterias Gramnegativas/microbiología , Hospitalización , Humanos , Aguas del Alcantarillado/microbiología , Purificación del Agua
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