Clinical and Epidemiological Characteristics of Mpox in HIV-Infected and Uninfected Men Who Have Sex with Men: A Retrospective Study in Lisbon.

The resurgence of Mpox, predominantly among men who have sex with men (MSM), has prompted an analysis of its clinical manifestations and epidemiological patterns, particularly in individuals living with human immunodeficiency virus (HIV). This retrospective study aims to delineate and compare the clinical presentations and epidemiological characteristics of Mpox among HIV-positive and HIV-negative individuals. A total of 58 confirmed Mpox cases from a dermatology department in Lisbon were analyzed, focusing on mucocutaneous manifestations, systemic symptoms, and laboratory parameters. Our findings indicate no significant difference in disease severity and presentation between HIV-positive and HIV-negative groups, suggesting that HIV status may not be a determinant of Mpox severity, but rather an indicator of increased sexual risk behaviors, a recognized risk factor for Mpox transmission.

Monkeypox Diagnosis by Cutaneous and Mucosal Findings.

A monkeypox outbreak has been reported in several countries since early May 2022. Human monkeypox (MPX) diagnosis is based on a clinical suspicion supported by typical skin and mucosal lesions, confirmed with molecular testing. We present the results of all MPX confirmed patients presenting to our department until July 15 of 2022, describing the characteristics of the lesions at diagnosis. In total, 47 patients were included, all men and 44.7% (n = 21) were HIV-positive. Skin lesions were noted in all patients. The most commonly affected area was the genital region (63.8%), followed by the anorectal region (46.8%). Extra anogenital mucosal (oral or conjunctival mucosa) involvement was reported in three patients. Typical skin findings included erythematous papules, whitish, umbilicated papules, some with a necrotic center and an elevated whitish border. Most patients had lesions in multiple phases presenting simultaneously. Correct identification of MPX skin and mucosal lesions is crucial to avoid late diagnosis and prevent further spreading, ensuring less worldwide morbidity.

Monkeypox infection and bacterial cellulitis: a complication to look for.

Human monkeypox (MPX) is an endemic zoonotic disease in regions of Africa caused by the monkeypox virus, with recent outbreaks in several non-African countries. In this study, we present two cases of patients with MPX infection complicated by a deep skin infection. Both patients presented to our dermatology clinic with a clinical syndrome characteristic of MPX. The diagnosis was confirmed based on swabs of skin lesions. Both patients later returned to our clinic with erythema, pain, and edema at the site of previous papules and were diagnosed with deep skin bacterial infection. In this study we provide information on what we believe was an underreported MPX infection complication and give some advice on preventing cases of cellulitis in these patients.

Human monkeypox coinfection with acute HIV: an exuberant presentation.

Human monkeypox (MPX) is a zoonotic endemic disease in regions of Africa caused by the monkeypox virus, with a recent outbreak in several non-African countries. We report a case of a 24-year-old male patient with a concurrent diagnosis of MPX and acute HIV infection who presented to our Emergency Care Dermatology Clinic with disseminated papules throughout the trunk, face and genital area. On the perianal area, several grouped umbilicated whitish papules in a kissing lesion configuration could be seen. Laboratory workups were consistent with recent HIV infection, and swab samples from the lesion surfaces were positive for monkeypox virus. We provide novel information on the clinical presentation of MPX, expanding the data pool of the clinical manifestations of which health workers should be aware.

Psychometric Properties of the Brazilian Version of the Sport Anxiety Scale-2.

Competitive anxiety (CA) is an emotional reaction manifested at a somatic and/or cognitive level that regularly appears before or during sports competitions and can significantly impact an athlete's performance. Given the scarcity of validated instruments available for evaluating the competitive-anxiety trait in the Brazilian context, this study aimed to investigate the psychometric properties of the Sport Anxiety Scale-2 (SAS-2). The study sample was composed of 238 professional and amateur athletes aged 13 years or older who practice different sports modalities. The results of confirmatory factor analysis (CFA) revealed adequate fit indices of the original three-factor theoretical model of the SAS-2 after including a correlation between the errors for items 6 and 12 of the somatic anxiety subscale (CFI = 0.97, TLI = 0.96, RMSEA = 0.08, WRMR = 1.04). For convergent and divergent validity, the SAS-2 subscales exhibited a positive and strong correlations with the Competitive State Anxiety Inventory-2R (CSAI-2R; r = 0.52-0.82), weak to moderate correlations with the State-Trait Anxiety Inventory - only the trait scale (STAI-T; r = 0.49-0.59), weak correlations with the Social Phobia Inventory (SPIN; r = 0.29-0.41) and weak to moderate correlations with the Patient Health Questionnaire (PHQ-9; r = 0.49-0.56). The SAS-2 was also able to discriminate among participants with and without social anxiety, general trait anxiety and depressive symptoms, thus confirming its discriminant validity. According to ROC curve analysis, the cutoff point at a score of 29 indicated the optimal balance of sensitivity (0.74) and specificity (0.82). The internal consistency (α = 0.73-0.86) and the test-retest reliability (ICC = 0.73-0.80) were satisfactory. These results indicated that the Brazilian version of the SAS-2 exhibited satisfactory psychometric performance and could be used in the Brazilian context.

Propriedades psicométricas da versão brasileira do behavioral inhibition instrument (BII) e associações com sintomas psicopatológicos / Psychometric properties of the brazilian version of the behavioral inhibition instrument (BII) and associations with psychopathological symptoms / Propiedades psicométricas de la versión brasileña del behavioral inhibition instrument (BII) e sus asociaciones con síntomas psicopatológicos

Os objetivos desse estudo foram investigar propriedades psicométricas da versão brasileira do Behavioral Inhibition Instrument (BII) e suas associações com sintomas de ansiedade e depressão em crianças e adolescentes. Participaram 838 estudantes com idades entre 9-18 anos (M=12,89; DP=2,10) de uma amostra comunitária respondendo a versão brasileira do BII e questionários de autorrelato de sintomas de ansiedade e depressão. Os resultados demonstraram que a prevalência de crianças e adolescentes na categoria de alta inibição comportamental foi de 16,6%. O BII apresentou propriedades psicométricas satisfatórias com maiores níveis de inibição comportamental correlacionados a maiores níveis de sintomas de ansiedade e depressão, especialmente para sintomas de fobia social. Além disso, participantes com altos escores de inibição comportamental tiveram maior probabilidade de apresentar sintomas de ansiedade em um espectro clínico ou subclínico, especialmente para fobia social. Implicações para intervenções preventivas precoces são brevemente discutidas...

The aims of this study were to investigate psychometric properties of the Behavioral Inhibition Instrument (BII) and their association with depression and anxiety symptoms in children and adolescents. Eight hundred and thirty-eight students aged 9-18 years (M=12.89, SD=2.10) from a community sample answered the Brazilian-Portuguese version of the BII and self-report questionnaires of depression and anxiety symptoms. Results showed the prevalence of children and adolescents in the high behavioral inhibition (BI) category was 16.6%. The BII presented satisfactory psychometric properties with higher levels of BI being correlated to higher levels of depression and anxiety symptoms, especially social phobia symptoms. Also participants with higher BI scores were more likely to present anxiety symptoms in a subclinical or clinical range, especially for social phobia. Implications for early preventive interventions are briefly discussed...

Los objetivos de este estudio fueron investigar las propiedades psicométricas de la versión brasileña del Behavioral Inhibition Instrument (BII) y sus asociaciones con los síntomas de ansiedad y depresión en niños y adolescentes. Ochocientos treinta y ocho (838) estudiantes con edades entre 9 y 18 años (M=12,89; DP=2,10) de una muestra comunitaria respondieron a la versión brasileña del BII y a cuestionarios auto-aplicables de síntomas de ansiedad y depresión. Los resultados demuestran que el predominio de niños y adolescentes en la categoría de alta inhibición conductual fue de 16,6%. El BII presentó propiedades psicométricas satisfactorias con mayores niveles de inhibición conductual correlacionándose a mayores niveles de síntomas de ansiedad y depresión, especialmente para fobia social. Además, los participantes con altos puntajes de inhibición conductual tuvieron mayor probabilidad de presentar síntomas de ansiedad en un espectro clínico o subclínico, especialmente para fobia social. Algunas implicancias para realizar intervenciones preventivas precoces son brevemente discutidas...

Propriedades psicométricas da versão brasileira do behavioral inhibition instrument (BII) e associações com sintomas psicopatológicos / Psychometric properties of the brazilian version of the behavioral inhibition instrument (BII) and associations with psychopathological symptoms / Propiedades psicométricas de la versión brasileña del behavioral inhibition instrument (BII) e sus asociaciones con síntomas psicopatológicos

Os objetivos desse estudo foram investigar propriedades psicométricas da versão brasileira do Behavioral Inhibition Instrument (BII) e suas associações com sintomas de ansiedade e depressão em crianças e adolescentes. Participaram 838 estudantes com idades entre 9-18 anos (M=12,89; DP=2,10) de uma amostra comunitária respondendo a versão brasileira do BII e questionários de autorrelato de sintomas de ansiedade e depressão. Os resultados demonstraram que a prevalência de crianças e adolescentes na categoria de alta inibição comportamental foi de 16,6%. O BII apresentou propriedades psicométricas satisfatórias com maiores níveis de inibição comportamental correlacionados a maiores níveis de sintomas de ansiedade e depressão, especialmente para sintomas de fobia social. Além disso, participantes com altos escores de inibição comportamental tiveram maior probabilidade de apresentar sintomas de ansiedade em um espectro clínico ou subclínico, especialmente para fobia social. Implicações para intervenções preventivas precoces são brevemente discutidas.(AU)

The aims of this study were to investigate psychometric properties of the Behavioral Inhibition Instrument (BII) and their association with depression and anxiety symptoms in children and adolescents. Eight hundred and thirty-eight students aged 9-18 years (M=12.89, SD=2.10) from a community sample answered the Brazilian-Portuguese version of the BII and self-report questionnaires of depression and anxiety symptoms. Results showed the prevalence of children and adolescents in the high behavioral inhibition (BI) category was 16.6%. The BII presented satisfactory psychometric properties with higher levels of BI being correlated to higher levels of depression and anxiety symptoms, especially social phobia symptoms. Also participants with higher BI scores were more likely to present anxiety symptoms in a subclinical or clinical range, especially for social phobia. Implications for early preventive interventions are briefly discussed.(AU)

Los objetivos de este estudio fueron investigar las propiedades psicométricas de la versión brasileña del Behavioral Inhibition Instrument (BII) y sus asociaciones con los síntomas de ansiedad y depresión en niños y adolescentes. Ochocientos treinta y ocho (838) estudiantes con edades entre 9 y 18 años (M=12,89; DP=2,10) de una muestra comunitaria respondieron a la versión brasileña del BII y a cuestionarios auto-aplicables de síntomas de ansiedad y depresión. Los resultados demuestran que el predominio de niños y adolescentes en la categoría de alta inhibición conductual fue de 16,6%. El BII presentó propiedades psicométricas satisfactorias con mayores niveles de inhibición conductual correlacionándose a mayores niveles de síntomas de ansiedad y depresión, especialmente para fobia social. Además, los participantes con altos puntajes de inhibición conductual tuvieron mayor probabilidad de presentar síntomas de ansiedad en un espectro clínico o subclínico, especialmente para fobia social. Algunas implicancias para realizar intervenciones preventivas precoces son brevemente discutidas.(AU)