RESUMEN
A recent reinvestigation of aerial parts of Wedelia paludosa D.C. is described and reports, for the first time, the isolation of iso-kaurenoic acid from this species.
Asunto(s)
Diterpenos/aislamiento & purificación , Extractos Vegetales/aislamiento & purificación , Wedelia/química , Diterpenos/química , Diterpenos/farmacología , Extractos Vegetales/química , Extractos Vegetales/farmacologíaRESUMEN
A recent reinvestigation of aerial parts of Wedelia paludosa D.C. is described and reports, for the first time, the isolation of iso-kaurenoic acid from this species.
Uma recente reinvestigação das partes aéreas de Wedelia paludosa D.C. é descrita e relata, pela primeira vez, o isolamento do ácido iso-caurenóico desta espécie.
Asunto(s)
Diterpenos/aislamiento & purificación , Extractos Vegetales/aislamiento & purificación , Wedelia/química , Diterpenos/química , Diterpenos/farmacología , Extractos Vegetales/química , Extractos Vegetales/farmacologíaRESUMEN
Several new 6-(3-pyrazolylpropyl) derivatives of 1,4-naphthohydroquinone-1,4-diacetate (NHQ-DA) have been prepared by chemical modifications of the Diels-Alder adduct of alpha-myrcene and 1,4-benzoquinone. All these new compounds and precursors have been evaluated in vitro for their cytotoxicity against cultured human cancer cells of MB-231 breast-adeno carcinoma, A-549 lung carcinoma, and HT-29 colon carcinoma. GI(50) values ranged in and below the micromolar concentration level.
Asunto(s)
Acetatos/farmacología , Antineoplásicos/farmacología , Proliferación Celular/efectos de los fármacos , Hidroquinonas/farmacología , Acetatos/síntesis química , Antineoplásicos/síntesis química , Supervivencia Celular/efectos de los fármacos , Relación Dosis-Respuesta a Droga , Células HT29 , Humanos , Hidroquinonas/síntesis química , Concentración 50 Inhibidora , Estructura Molecular , Relación Estructura-ActividadRESUMEN
Several new prenyl-1,2-naphthohydroquinone derivatives have been prepared by chemical modifications of Diels-Alder products which were obtained from cycloaddition of alpha-myrcene to 1,2-benzoquinone and then evaluated in vitro for their cytotoxic activity against A-549 lung carcinoma, HT-29 colon carcinoma, and MB-231 breast adeno-carcinoma culture cells. Most of them exhibited GI50 values in the microM-concentration level.
Asunto(s)
Antineoplásicos/síntesis química , Hidroquinonas/síntesis química , Antineoplásicos/farmacología , Línea Celular Tumoral , Humanos , Hidroquinonas/farmacología , Relación Estructura-ActividadRESUMEN
Several podophyllotoxin derivatives lacking the methylenedioxy group or with different functionalization of the A-ring of the cyclolignan skeleton have been prepared and evaluated for their cytotoxic activities on four neoplastic cell lines (P-388, A-549, HT-29 and MEL-28). Most of them maintained their cytotoxicity at the microM level.
Asunto(s)
Antineoplásicos/síntesis química , Lignanos/síntesis química , Podofilotoxina/análogos & derivados , Animales , Antineoplásicos/farmacología , Línea Celular Tumoral/efectos de los fármacos , Dioxanos/síntesis química , Dioxanos/farmacología , Dioxoles/síntesis química , Dioxoles/química , Dioxoles/farmacología , Ensayos de Selección de Medicamentos Antitumorales , Humanos , Lignanos/farmacología , Espectroscopía de Resonancia Magnética , Ratones , Modelos Químicos , Estructura Molecular , Podofilotoxina/farmacología , Relación Estructura-ActividadRESUMEN
Several myrcenylhydroquinone derivatives have been evaluated for their cytotoxic activity against three neoplastic cell line cultures and compared with the activity previously observed on other neoplastic systems. Also a new series of this type of compounds has been prepared and the compounds synthesised have been evaluated by their GI(50) values.
