Evaluation of lap belt-pelvis load transfer in frontal impact simulations using finite element occupant models.

OBJECTIVE: The goal of this study was to examine the relationship between lap belt tension and force measured at the iliac wing and the effects of model type and torso posture on this relationship. From this analysis, preliminary transfer functions were developed to predict loads applied to the iliac wing as a function of lap belt tension at magnitudes typically measured in sled and vehicle crash tests. METHODS: A DOE study was conducted to provide a robust assessment of the lap belt-pelvis load relationship under various conditions. The GHBMC, THUMS, and THOR FE models were positioned in upright and reclined postures with several other intrinsic and extrinsic parameters varied for a total of 360 simulations. For the HBMs, instrumentation was developed to measure ASIS load at each iliac wing. Simulations that resulted in submarining were identified and removed from the subsequent development of lap belt-ASIS force transfer functions. RESULTS: The GHBMC exhibited submarining more frequently than the THUMS and THOR models. In addition to submarining, there were several cases in which the lap belt remained below the ASIS instrumentation or roped during the model's forward excursion. These phenomena, particularly prevalent in the THUMS model, also influenced how the lap belt engaged the ASIS instrumentation and were thus eliminated from the transfer function development. Transfer functions relating peak lap belt tension and corresponding ASIS force magnitudes were developed for the GHBMC and THOR models in upright and reclined postures. In the upright posture, the THOR showed a higher level of ASIS load measured for a given level of lap belt tension than the GHBMC; however, in recline the lap belt-pelvis load relationship was similar between the two models. CONCLUSIONS: The lap belt-pelvis load relationship was found to be affected by model type, posture, the area in which the ASIS instrumentation was defined, and occupant kinematics. This study showed it was possible to minimize the ASIS force by having the lap belt engage low on the pelvis and upper thighs, though further study is needed to determine if this loading mechanism is truly protective from an injury standpoint or an artifact of bypassing the ASIS instrumentation. The transfer function that showed the highest ASIS force measured for a given level of lap belt tension is recommended for future use.

Frontal-Crash Occupant Protection in the Rear Seat: Submarining and Abdomen/Pelvis Response in Midsized Male Surrogates.

Frontal-crash sled tests were conducted to assess submarining protection and abdominal injury risk for midsized male occupants in the rear seat of modern vehicles. Twelve sled tests were conducted in four rear-seat vehicle-bucks with twelve post-mortem human surrogates (PMHS). Select kinematic responses and submarining incidence were compared to previously observed performance of the Hybrid III 50th-percentile male and THOR-50M ATDs (Anthropomorphic Test Devices) in matched sled tests conducted as part of a previous study. Abdominal pressure was measured in the PMHS near each ASIS (Anterior Superior Iliac Spine), in the inferior vena cava, and in the abdominal aorta. Damage to the abdomen, pelvis, and lumbar spine of the PMHS was also identified. In total, five PMHS underwent submarining. Four PMHS, none of which submarined, sustained pelvis fractures and represented the heaviest of the PMHS tested. Submarining of the PMHS occurred in two out of four vehicles. In the matched tests, the Hybrid III never underwent submarining while the THOR-50M submarined in three out of four vehicles. Submarining occurred in vehicles having both conventional and advanced (pretensioner and load limiter) restraints. The dominant factors associated with submarining were related to seat pan geometry. While the THOR-50M was not always an accurate tool for predicting submarining in the PMHS, the Hybrid III could not predict submarining at all. The results of this study identify substantive gaps in frontal-crash occupant protection in the rear seat for midsized males and elucidates the need for additional research for rear-seat occupant protection for all occupants.

Study on the dynamic change of volatile components of white tea in the pile-up processing based on sensory evaluation and ATD-GC-MS Technology.

The pile-up processing has a great impact on the flavor of white tea. To investigate the effects of the volatile accumulation of white tea with different piling thickness treatments, tea leaves from different thickness treatments were subjected to sensory quantitative description analysis and ATD-GC-MS detection in this study. As a result, 122 volatile components were identified from white tea with different treatments. A total of 8 key compounds, including isovaleraldehyde, isobutyraldehyde, 2-methyl-butanal, 1-octene-3-ol, linalool, pentanoic acid, hexanal and 1-hexanol were screened out using multivariate statistical analysis, which were characteristic components of grassy, floral-fruity, pekoe aroma and sweet flavors. The results of the selected key characteristic volatile compounds were consistent with the sensory quantitative description. The aroma of mid-pile dried tea (MD) was exhibited a harmonious and pleasant overall flavor. This study provides a novel insight into the accumulation of volatile during the withering step of white tea production.

Hypothyroidism After Use of Immune Checkpoint Inhibitor Therapy in Patient With Graves' Disease: Cure?

Immune checkpoint inhibitors (ICIs) are frequently used as treatment for many malignancies. Immune-related adverse events (irAEs) due to use of ICIs are common. Thyroid involvement is the most common endocrine irAE. Here, we present an unusual case of Graves' disease potentially cured due to destructive thyroiditis caused by inflammation due to ICIs. Thyroid irAEs are more common with programmed cell death protein-1 (PD-1) inhibitor or programmed cell death-ligand 1 (PD-L1) inhibitors than cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) inhibitors. Baseline and serial monitoring of thyroid function tests is recommended.

Assessment of finite element human body and ATD models in estimating injury risk in far-side impacts using field-based injury risk.

The objective of this study was to assess the ability of finite element human body models (FEHBMs) and Anthropometric Test Device (ATD) models to estimate occupant injury risk by comparing it with field-based injury risk in far-side impacts. The study used the Global Human Body Models Consortium midsize male (M50-OS+B) and small female (F05-OS+B) simplified occupant models with a modular detailed brain, and the ES-2Re and SID-IIs ATD models in the simulated far-side crashes. A design of experiments (DOE) with a total of 252 simulations was conducted by varying lateral ΔV (10-50kph; 5kph increments), the principal direction of force (PDOF 50°, 60°, 65°, 70°, 75°, 80°, 90°), and occupant models. Models were gravity-settled and belted into a simplified vehicle model (SVM) modified for far-side impact simulations. Acceleration pulses and vehicle intrusion profiles used for the DOE were generated by impacting a 2012 Camry vehicle model with a mobile deformable barrier model across the 7 PDOFs and 9 lateral ΔV's in the DOE for a total of 63 additional simulations. Injury risks were estimated for the head, chest, lower extremity, pelvis (AIS 2+; AIS 3+), and abdomen (AIS 3+) using logistic regression models. Combined AIS 3+ injury risk for each occupant was calculated using AIS 3+ injury risk estimations for the head, chest, abdomen, and lower extremities. The injury risk calculated using computational models was compared with field-based injury risk derived from NASS-CDS by calculating their correlation coefficient. The field-based injury risk was calculated using risk curves that were created based on real-world crash data in a previous study (Hostetler et al., 2020). Occupant age (40 years), seatbelt use (belted occupant), collision deformation classification, lateral ΔV, and PDOF of the crash event were used in these curves to estimate field injury risk. Large differences in the kinematics were observed between HBM and ATD models. ATD models tended to overestimate risk in almost every case whereas HBMs yielded better risk estimates overall. Chest and lower extremity risks were the least correlated with field injury risk estimates. The overall risk of AIS 3+ injury risk was the strongest comparison to the field data-based risk curves. The HBMs were still not able to capture all the variance but future studies can be carried out that are focused on investigating their shortfalls and improving them to estimate injury risk closer to field injury risk in far-side crashes.

Comparison of child and ATD belt fit and posture on belt-positioning boosters during self-selected, holding device, and nominal conditions.

OBJECTIVE: Pediatric anthropomorphic test devices (ATDs) are important tools for the assessment of child occupant protection and should represent realistic child belt fit and posture on belt-positioning boosters. Previous comparisons have been made to children in either self-selected or nominal postural conditions. This study compares belt fit and postural measurements between pediatric ATDs and a single cohort of children assuming different postures on boosters: self-selected, holding a portable electronic device, and nominal. METHODS: A cohort of children (n = 25) were evaluated in a stationary vehicle on five boosters and in three postural conditions: nominal, self-selected, and a representative holding electronic device position. The Hybrid III 6- and 10-year-old and Q-Series 6- and 10-year-old ATDs were evaluated in the same five boosters and in two postural conditions: nominal and a representative holding electronic device position. A 3D coordinate measurement device was used to quantify belt fit (shoulder belt score, lap belt score, maximum gap size, and gap length) and anatomic landmark positions (head, suprasternale, ASIS, and patella). Landmark positions and belt fit were compared between ATDs and children for each booster and postural condition, and Pearson correlations (r) were assessed across boosters. RESULTS: ATDs generally represented Nominal child postures across boosters. In the Device condition, ATDs were seldom able to be positioned to represent both the torso and head position of children, due to limited ATD spinal flexibility. When the torso position was matched, the ATD head was more rear by 63 mm. Correlations between Nominal child and ATD belt fit and belt gap metrics were generally weak and not significant, with the exception of lap belt score (all ATDs p < 0.07, r = 0.8549-0.9857). DISCUSSION: ATDs were generally able to represent realistic child postures and lap belt fit in Nominal and short duration Self-selected postures in a laboratory setting. However, these results display the potential difficulty of utilizing ATDs to represent more naturalistic child postures, especially the more forward head positions and flexed spinal posture associated with utilizing a portable electronic device.

The Role of Serotonin in Fear Learning and Memory: A Systematic Review of Human Studies.

Fear is characterized by distinct behavioral and physiological responses that are essential for the survival of the human species. Fear conditioning (FC) serves as a valuable model for studying the acquisition, extinction, and expression of fear. The serotonin (5-hydroxytryptamine, 5-HT) system is known to play a significant role in emotional and motivational aspects of human behavior, including fear learning and expression. Accumulating evidence from both animal and human studies suggests that brain regions involved in FC, such as the amygdala, hippocampus, and prefrontal cortex, possess a high density of 5-HT receptors, implicating the crucial involvement of serotonin in aversive learning. Additionally, studies exploring serotonin gene polymorphisms have indicated their potential influence on FC. Therefore, the objective of this work was to review the existing evidence linking 5-HT with fear learning and memory in humans. Through a comprehensive screening of the PubMed and Web of Science databases, 29 relevant studies were included in the final review. These studies investigated the relationship between serotonin and fear learning using drug manipulations or by studying 5-HT-related gene polymorphisms. The results suggest that elevated levels of 5-HT enhance aversive learning, indicating that the modulation of serotonin 5-HT2A receptors regulates the expression of fear responses in humans. Understanding the role of this neurochemical messenger in associative aversive learning can provide insights into psychiatric disorders such as anxiety and post-traumatic stress disorder (PTSD), among others.

Association of A1AT genetic polymorphism and NSCLC: a case- control study in Egyptian population.

BACKGROUND: Lung cancer mortality is higher than other forms of cancer. Genetic tendencies in cancer patients have long been known. Given the link between A1ATD and numerous lung disorders, it is worth investigating if this genetic trait is linked to a higher risk of developing LC, as the lung is the most afflicted organ in individuals with severe A1ATD. This study is intended to investigate the possible association between AAT rs17580 and rs8004738 gene polymorphisms and susceptibility to non-small cell lung cancer for early prediction in Egyptians. METHODS: A case-control study was performed on 124 NSCLC cases and 124 healthy controls from 2021 to 2022 in the oncology center of Mansoura University. Peripheral blood was used to obtain genomic DNA. ARMS-PCR was used to genotype SNPs and other chemical parameters. Windows SPSS Statistics was used to review, encode, and tabulate the acquired data. RESULTS: A molecular study for A1AT rs17580 and rs8004738 genotypes showed that NSCLC cases were significantly associated with a higher proportion of mutant S (T) and mutant Z (A) alleles (p = 0.042, 0.041, respectively). Different A1AT genotypes (MS, MZ, SS, SZ, and ZZ) showed no significant association with NSCLC or NLR. CONCLUSION: S and Z alleles might have significant impacts on NSCLC risk and can be useful for detecting and protecting individuals who may be vulnerable to carcinogens. Further research with larger sample sizes is needed to confirm the current findings.

Frontal-oblique impact sled tests of a rearward-facing child restraint system with and without a support leg.

OBJECTIVE: To quantify the head and neck injury metrics of an anthropometric test device (ATD) in a rearward-facing child restraint system (CRS), with and without a support leg, in frontal-oblique impacts. METHODS: Sled tests using the Federal Motor Vehicle Safety Standards (FMVSS) 213 frontal crash pulse (48 km/h, 23 g) were performed with a simulated Consumer Reports test buck, which comprised a test bench that mimics the rear outboard vehicle seat of a sport utility vehicle (SUV). The test bench was rigidised to increase durability for repeated testing and the seat springs and cushion were replaced every five tests. A force plate was mounted to the floor of the test buck directly in front of the test bench to measure support leg peak reaction force. The test buck was rotated 30° and 60° relative to the longitudinal axis of the sled deck to represent frontal-oblique impacts. The door surrogate from the FMVSS 213a side impact test was rigidly attached to the sled deck adjacent to the test bench. The 18-month-old Q-Series (Q1.5) ATD was seated in a rearward-facing infant CRS, which was attached to the test bench with either rigid lower anchors or a three-point seatbelt. The rearward-facing infant CRS was tested with and without a support leg. Conductive foil was attached to the upper edge of the door panel and a strip of conductive foil was attached to the top of the ATD head so that a voltage signal quantified contact with the door panel. A new CRS was used for each test. A repeat test was performed for each condition for a total of 16 tests. DATA SOURCES: Resultant linear head acceleration 3 ms clip; head injury criterion 15 ms (HIC15); peak neck tensile force; peak neck flexion moment; potential difference between the ATD head and the door panel; support leg peak reaction force. RESULTS: The presence of a support leg significantly reduced head injury metrics (p < 0.001) and peak neck tensile force (p = 0.004) compared to tests without a support leg. Rigid lower anchors were associated with significant reductions in head injury metrics and peak neck flexion moment (p < 0.001) compared to tests that attached the CRS with the seatbelt. The 60° frontal-oblique tests had significantly elevated head injury metrics (p < 0.01) compared to the 30° frontal-oblique tests. No ATD head contact with the door was observed for 30° frontal-oblique tests. The ATD head contacted the door panel in the 60° frontal-oblique tests when the CRS was tested without the support leg. Average support leg peak reaction forces ranged from 2167 to 4160 N. The 30° frontal-oblique sled tests had significantly higher support leg peak reaction forces (p < 0.001) compared to the 60° frontal-oblique sled tests. CONCLUSIONS: The findings of the current study add to the growing body of evidence regarding the protective benefits of CRS models with a support leg and rigid lower anchors.

Solvent-free automated thermal desorption-gas chromatography/mass spectrometry for direct screening of hazardous compounds in consumer textiles.

The global production of textiles utilizes numerous large-volume chemicals that may remain to some extent in the finished garments. Arylamines, quinolines, and halogenated nitrobenzene compounds are possible mutagens, carcinogens and/or skin sensitizers. For prevention, control of clothing and other textiles must be improved, especially those imported from countries without regulations of textile chemicals. An automated analytical methodology with on-line extraction, separation, and detection would largely simplify screening surveys of hazardous chemicals in textiles. Automated thermal desorption-gas chromatography/mass spectrometry (ATD-GC/MS) was developed and evaluated as a solvent-free, direct chemical analysis for screening of textiles. It requires a minimum of sample handling with a total run time of 38 min including sample desorption, chromatographic separation, and mass spectrometric detection. For most of the studied compounds, method quantification limit (MQL) was below 5 µg/g for 5 mg of textile sample, which is sufficiently low for screening and control of quinoline and arylamines regulated by EU. Several chemicals were detected and quantified when the ATD-GC/MS method was applied in a limited pilot screening of synthetic fiber garments. A number of arylamines were detected, where some of the halogenated dinitroanilines were found in concentrations up to 300 µg/g. This is ten times higher than the concentration limit for similar arylamines listed by the EU REACH regulation. Other chemicals detected in the investigated textiles were several quinolines, benzothiazole, naphthalene, and 3,5-dinitrobromobenzene. Based on the present results, we suggest ATD-GC/MS as a screening method for the control of harmful chemicals in clothing garments and other textiles.

Effect of naturalistic seating postures and seatbelt routing on booster-seated Q6 ATD kinematics and kinetics in frontal impacts.

RESEARCH QUESTIONS / OBJECTIVE: Test protocols evaluate restraint performance with pediatric ATDs placed in an ideal seating posture. However, real-world evidence suggests that ideal test conditions do not always reflect actual occupant positions. Prior studies have also shown that booster seat designs affect the position of the seatbelt around the child. Occupants in naturalistic seating postures, coupled with potentially unfavorable seatbelt positions, could result in adverse kinematics and kinetics in a crash. Therefore, the aim of this study was to quantify the effect of different naturalistic seating postures on the response of the Q6 ATD restrained on boosters with varying initial static belt fit in a frontal impact. METHODS/DATA SOURCES: The Q6 ATD was positioned on two booster seats of similar design but varying static belt fit metrics in three seating postures: reference, leaning forward, and leaning inboard. These booster seats were chosen from extensive belt fit studies on human volunteers and ATDs, and were defined as follows:The booster-seated ATD was restrained on the simulated Consumer Reports test buck (2010 Ford Flex 2nd row seat) with a front blocker plate using a 3-point lap-shoulder belt with a retractor and pretensioner. The sled environment was subjected to the FMVSS 213 frontal impact pulse, and each booster and seating posture was evaluated twice (n = 12 sled tests). Kinematic and kinetic measures were recorded. A linear regression analysis was conducted across postures on each booster. Further, a paired t-test analysis was conducted across booster seats for each seating posture. RESULTS: Across seating postures, the reference posture exhibited similar or higher kinematic and kinetic metric values compared to the leaning forward and leaning inboard postures on both boosters. However, both leaning forward (Booster A = 279.5 ± 21.6 mm; Booster B = 298.8 ± 1.5 mm) and leaning inboard (Booster A = 308.7 ± 1.1 mm; Booster B = 331.4 ± 8.5 mm) postures generally resulted in greater head excursion than the reference posture (Booster A = 285.0 ± 16.9 mm; Booster B = 288.1 ± 1.5 mm), indicating greater potential for head contact. Between boosters, Booster A resulted in significantly lower head 3 ms clip acceleration (p = 0.0026), HIC15 (p = 0.0008), upper neck tensile force (Fz)(p = 0.0057), chest 3 ms clip acceleration (p = 0.0013), and right abdominal pressure (p = 0.0163), and significantly higher left ASIS force (Fx)(p = 0.0150) and left (p = 0.0489) and right (p = 0.0088) ASIS moment (My) than Booster B. Upper neck tensile forces on Booster B crossed the 20% and 50% thresholds for AIS3 + injury. Lower abdominal pressure and higher ASIS forces and moments on Booster A suggest that the lap belt loaded the ASIS appropriately, and hence, relatively better kinematics than Booster B. SIGNIFICANCE OF RESULTS: This study shows that booster design affects static belt fit which can have an effect on dynamic crash performance and assessment criteria. By connecting static belt fit to dynamic performance, these effects may have the potential to help guide booster seat design.

Diabetic post-covid mucormycosis: A dermatoglyphic prediction.

Aim: To identify the characteristic pattern/parameter among diabetic post-covid mucormycosis patients which may further help in identifying such susceptible patients in a much earlier course of the disease. Materials and Methods: The study was done with 30 diabetic patients (21 males and 9 females) admitted in RIMS Ranchi during the second wave of Covid-19 for post-covid complications. Palm and fingerprint pattern was taken by ink and pad method to measure the qualitative and quantitative parameters. Result: Diabetic post-covid mucormycosis patients were found to have predominantly whorl pattern in males, loop in females, and C-line pattern absent in 36.6%. Proximal axial triradii with ulnar deviation was 76.6%. All the ridge counts (except ab ridge count of right hand) when compared with hypothesized value were found to be significant with P value (<0.005). None of the three angles measured were found to be significant. Conclusion: All the ridge counts (except ab ridge count of right hand) were found to be a reliable parameter for the diagnosis of diabetic post-covid mucormycosis. ATD angle known to be the most reliable parameter for diagnosis of diabetes mellitus in dermatoglyphics is found to be nonreliable with respect to diabetes post-covid mucormycosis.

Head excursions of rearward-facing child restraint systems in rear impacts.

OBJECTIVE: The aim of the current study was to quantify the head excursions of pediatric anthropomorphic test devices (ATDs) seated in rearward-facing child restraint system (CRS) models during rear impact sled tests and compare to roof heights of vehicles in the current fleet to assess the possibility of head contact against the vehicle roof. METHODS: Head excursions of ATDs seated in rearward-facing CRS models were analyzed from high-speed video data from 14 rear impact sled tests across two different series. Tests were conducted in rigidized vehicle seats from recent model year vehicles. Rearward-facing infant and convertible CRS models were tested with a variety of pediatric ATDs aged 12 months to 6 years in a variety of installation conditions (e.g., lower anchors or seat belt, anti-rotation features, etc). Maximum ATD head excursions in plane of the seatback were compared to previously measured roof heights of 87 different vehicles. RESULTS: The roof heights in all sedan seating positions (n = 58) and SUV/CUV/minivan seating positions (n = 60) were greater than the largest maximum ATD head excursions in plane of the seatback (792 mm). Head contact was possible in two of the pickup trucks which had roof heights of 730 and 775 mm. In all, 98% of vehicle seating positions measured in this study would accommodate all of the maximum ATD head excursions in plane of the seatback without contact. CONCLUSIONS: The risk of head contact against the vehicle interior roof appears low as maximum ATD head excursions in plane of the seatback were typically not great enough to reach the rooflines of the vehicles in the sample. Head contact appears possible in pickup trucks, where the window/roofline is directly behind the head restraint.

The effect of seatback deformation on out-of-position front-seat occupants in severe rear impacts.

OBJECTIVE: This study assesses the effects of seat deflection in severe oblique rear impacts with laterally out-of-position ATDs where the head is not supported by the head restraint. METHOD: Six high-speed rear sled tests were conducted at 48 km/h with a 195 degree PDOF. A lap-shoulder belted 50th percentile Hybrid III ATD was leaned inboard and seated in six different front passenger seats (A-F); five of the seats were selected from mid-sized sedans and one was a non-production rigidified Seat Integrated Restraint (SIR) seat. FRED-III pull tests resulted in seat stiffnesses that varied from 73 to 172 N/mm. Seat F had the greatest stiffness. The seat and ATD responses were assessed. The biomechanical responses were evaluated and compared to relevant IARVs. RESULTS: In all tests the ATD moved rearward and twisted the seat. There was limited differential motion of the torso relative to the seatback. The ATD position and PDOF prevented head restraint engagement allowing head and neck extension over the seatback. The seatback angle was measured on the inboard side. At maximum yield, it was greatest with Seat E, followed by Seat A and Seat D, at 71, 67 and 62 degrees, respectively. The duration of rearward deformation was also greatest with Seat A, Seat D and Seat E providing longer ride-down. The head, chest and upper neck responses were below IARVs. Lower-neck extension moments were above injury threshold with Seat B, C and F. Seat F had the highest lower-neck moment. CONCLUSION: Seats with greater deformation provided the greatest ride-down durations and the lowest overall biomechanical responses. The combination of high impact severity and lack of head support resulted in high lower-neck responses, highlighting the potential benefit of energy management from deforming seat structures.

Perspectives of rehabilitation professionals on assistive technology provision to young children in South Africa: a national survey.

PURPOSE: Various factors influence the selection of assistive technology for young children within a context with limited resources, such as South Africa. Rehabilitation professionals are required to weigh up different factors as part of their professional reasoning process when making assistive technology (AT) selections. Insight into the perceived influence of different factors may assist in understanding how professionals make decisions about AT in this context. MATERIALS AND METHODS: An online survey with questions designed using best-worst scaling was distributed to rehabilitation professionals throughout South Africa. Factors influencing assistive technology selection included in the best-worst survey were identified in previous phases of a larger project. A total of n = 451 rehabilitation professionals completed the survey by selecting the factors that were most and least influential on their assistive technology provision. RESULTS: Results of the survey were obtained by calculating the number of times each factor was selected as most influential across the entire sample, and across all questions, enabling the researchers to sort the items in terms of the frequency of selection. CONCLUSIONS: Even though the rehabilitation professionals that participated in the study provide services in a context with limited resources, assessment and factors pertaining to the assistive technology itself were generally perceived to be of greater influence than environmental factors. It is recommended that these factors be reflected in frameworks and models of AT selection.IMPLICATIONS FOR REHABILITATIONThe family's ability to support the implementation of AT is an important resource that is perceived to influence the selection of AT by an RP.Insight into the mind-set of professionals that are used to selecting AT within settings with limited resources may provide RPs in well-resourced contexts with guidance on how to do more, with less.RPs should aim to determine child preference and attitude towards AT during the AT selection process.RPs should be aware of their own influence on AT selection. Existing AT Selection models should be adapted to clearly reflect the influence of the recommending professional.

Graves' disease, its treatments, and the risk of atrial fibrillation: A Korean population-based study.

Background: Atrial fibrillation (AF) is occasionally diagnosed in individuals with Graves' disease. Definite treatments, including radioactive iodine therapy (RAIT) or surgery might lower the risk of AF in the literature. However, no studies have compared the effects of anti-thyroid drugs (ATDs), RAIT, and surgery on the risk of AF. Methods: This retrospective cohort study included 94,060 newly diagnosed Graves' disease patients and 470,300 controls from the Korean National Health Insurance database. The incidence of AF was evaluated in patients and controls. Patients were categorized based on treatment method into ATD (95.6%), RAIT (3.5%), and surgery (0.9%) groups. In the ATD group, the dose and duration of ATDs were calculated for each patient. In the RAIT and surgery groups, remission was defined as levothyroxine prescription. Results: Graves' disease patients had a 2.2-fold higher risk of developing AF than controls. Regardless of demographic factors, the patient group had a consistently higher risk of AF than controls, with the highest risk of AF (HR, 5.49) in the younger patient group. The surgery group had a similar risk of AF compared with controls, whereas the ATD (HR, 2.23) and RAIT (HR, 2.00) groups had increased risks of AF, even in patients reaching hypothyroid status after RAIT. Patients with higher dose or longer treatment duration of ATDs were at greater risk of AF. Conclusion: We observed differing risks of AF according to methods of treatment for Graves' disease, and that definite treatment can be an option for subjects needing sustained medical treatment considering the risk of AF.

Effectiveness of motor-cognitive dual-task exercise via telerehabilitation in Alzheimer's disease: An online pilot randomized controlled study.

OBJECTIVE: It is important to investigate the effectiveness of delivering the rehabilitation service using remote communication technologies, for conditions that face-to-face treatment is not possible. This study aimed to investigate the effectiveness of exercise treatment via home-based telerehabilitation (TR) in Alzheimer's disease (AD). METHODS: Twenty participants who were diagnosed as having the early-middle stage of AD were randomized into a TR group and control group. The TR group received real-time motor-cognitive dual-task exercise treatment via video conferencing, and the control group received no intervention for 6 weeks. The primary outcomes were Mini-Mental State Examination, Timed Up&Go Test, and the 5 Times Sit&Stand Test, and the secondary outcomes were One-leg Stance Test (OLST), Katz Activities of Daily Living Scale (Katz-ADL), Functional Independence Measure, Geriatric Depression Scale-Short Form, Beck Anxiety Scale, Zarit Caregiver Burden Inventory (ZCBI) and the Warwick Edinburgh Well-being Scale. Outcomes were measured at baseline and post-treatment. RESULTS: There was a significant difference in the mean change between the groups in favor of the TR group in all primary and secondary outcomes (p < .05), except for the ZCBI and OLST(p > .05). There was no significant difference in the comparison of the primary outcome measures between the groups in post-treatment results (p > .05); significant differences in all secondary outcome measures were observed in favor of the TR group (p < .05), except for the OLST, Katz-ADL, and ZCBI (p > .05). CONCLUSION: TR may provide a significant change in cognition and mobility, improve functional independence, and caregiver's well-being, and reduce anxiety and depressive symptoms in people with AD.

Guided growth versus varus osteotomy for type II avascular necrosis following surgery for developmental dysplasia of the hip.

AIMS: The aim of this study was to compare outcomes of guided growth and varus osteotomy in treating Kalamchi type II avascular necrosis (AVN) after open reduction and Pemberton acetabuloplasty for developmental dysplasia of the hip (DDH). METHODS: This retrospective study reviewed patients undergoing guided growth or varus osteotomy for Kalamchi type II AVN between September 2009 and January 2019. All children who had undergone open reduction and Pemberton acetabuloplasty for DDH with a minimum two-year follow-up were enrolled in the study. Demographic and radiological data, which included the head-shaft angle (HSA), neck-shaft angle (NSA), articulotrochanteric distance (ATD), Sharp angle (SA), and lateral centre-edge angle (LCEA) at baseline, two years, and at the extended follow-up, were compared. Revision rates were evaluated. Clinical outcomes using the Harris Hip Score were assessed two years postoperatively. RESULTS: A total of 24 patients underwent guided growth and 19 underwent varus osteotomy, over a mean period of 3.3 years (95% confidence interval (CI) 2.8 to 3.8) and 5.2 years (95% CI 4.5 to 6.0), respectively. There were no differences in demographic and preoperative radiological data, except for a younger age at time of acetabuloplasty and larger ATD for the osteotomy group. The HSA did not differ at two years and the extended follow-up because of postoperative rebound in the osteotomy group. The NSA of the osteotomy group remained smaller postoperatively. There were no significant differences in the follow-up ATD, SA, and LCEA, except for a smaller two-year ATD of the osteotomy group. Seven patients (29.2%) in the guided growth group underwent revision surgery and none in the osteotomy group. The Harris Hip Score was similar between groups. CONCLUSION: Guided growth and varus osteotomy had comparable results in improving caput valgum deformity, given the rebound of lateral tilting of the physis after osteotomy correction. There were no differences in clinical outcomes at two years postoperatively. Cite this article: Bone Joint J 2022;104-B(7):902-908.

Best Practices for Conducting Physical Reconstructions of Head Impacts in Sport.

Physical reconstructions are a valuable methodology for quantifying head kinematics in sports impacts. By recreating the motion of human heads observed in video using instrumented test dummies in a laboratory, physical reconstructions allow for in-depth study of real-world head impacts using well-established surrogates such as the Hybrid III crash test dummy. The purpose of this paper is to review all aspects of the physical reconstruction methodology and discuss the advantages and limitations associated with different choices in case selection, study design, test surrogate, test apparatus, text matrix, instrumentation, and data processing. Physical reconstructions require significant resources to perform and are therefore typically limited to small sample sizes and a case series or case-control study design. Their accuracy may also be limited by a lack of dummy biofidelity. The accuracy, repeatability, and sensitivity of the reconstruction process can be characterized and improved by good laboratory practices and iterative testing. Because wearable sensors have their own limitations and are not available or practical for many sports, physical reconstructions will continue to provide a useful and complementary approach to measuring head acceleration in sport for the foreseeable future.

Interactions between rearward-facing child restraint systems and the front row seatback in frontal impact sled tests.

OBJECTIVE: Some child restraint system (CRS) manufacturers specify a minimum distance between the CRS and the seatback, whereas others require that the CRS may contact the seatback but cannot be "braced"; however, few studies have investigated these interactions. Therefore, the aim was to investigate the interactions between the front row seat and rearward-facing CRS models with and without a support leg during frontal crashes. METHODS: Sled tests using the FMVSS 213 frontal crash pulse were performed with the Q1.5 and Q3 anthropomorphic test devices (ATDs) seated in rearward-facing infant and convertible CRS models, respectively. A front row vehicle seat was in front of the test bench in three track positions: brace, touch and gap. For the touch condition, the front row seat was translated aftward until the seatback contacted the CRS. For the brace condition, the front row seat was translated 20 mm aftward. For the gap condition, the front row seat was translated 50 mm forward. Each condition was tested with and without the support leg of the CRS. RESULTS: The tests with a support leg were associated with significantly (p = 0.007) lower resultant linear head acceleration 3 ms clip compared to the tests without a support leg, but the reduction of head injury criterion 15 ms (HIC15) was not significant (p = 0.057). The Q1.5 ATD in the rearward-facing infant CRS with a support leg had the lowest injury metrics for the touch and gap conditions, whereas the Q3 in the rearward-facing convertible CRS had the lowest head injury metrics for the brace condition. CONCLUSIONS: The use of a support leg provided a clear benefit in terms of reducing head injury metrics for the Q1.5 in the rearward-facing infant CRS, especially for the touch and gap conditions. The rearward-facing convertible CRS in the current study appears to benefit from being braced against the front row seat. However, further tests are required to allow further statistical comparisons and determine if these preliminary findings extend to other rearward-facing CRS models.