Evidencias de validez de la tarea de los dedos en una modalidad de administración asincrónica / Validity evidence of the finger task in an asynchronous administration modality

La batería de Autorregulación Cognitiva -TAC-es una herramienta informatizada para la evaluación de los principales procesos ejecutivos en una modalidad de administración presencial. Aunque sus características técnicas hacen viable su administración en una modalidad remota y asincrónica aún no cuenta con evidencias de validez y confiabilidad de sus puntuaciones en una modalidad de administración no presencial. Por ello, este estudio propone obtener evidencias de las propiedades psicométricas de la Tarea de los Dedos -TAC-en su modalidad de administración remota y asincrónica para la evaluación de la Inhibición comportamental y la flexibilidad cognitiva en personas adultas. Para cumplir con este objetivo, se analizó la presencia de dos efectos experimentales que aportan validez de constructo y se comparó su desempeño en las dos modalidades de administración. Finalmente, se analizó la confiabilidad de las puntuaciones a través del método de división por mitades. Los resultados obtenidos aportan evidencia empírica de las propiedades psicométricas del instrumento(AU)

The cognitive self-regulation battery -TAC-is a computerized tool designed to evaluate the work memory, three inhibitory processes and cognitive flexibility. There is still no evidence of validity and reliability of their scores in remote administration mode. The goal of this work is to obtain evidence of reliability and validity for the tac fingers task in remote and asynchronous administration mode for cognitive flexibility and behavioral inhibition evaluation in the adult population. It was analyzed iftwo experimental effects were detected. Its presence indicates the activation or participation of cognitive flexibility and behavioral inhibition in the resolution of activities proposed by the task. Also, the performance of the participants in both modalities was compared. The internal consistency was analyzed through the method of division by halves. The results obtained provide empirical evidence of psychometric properties of TAC fingers task for evaluation of cognitive flexibility and behavioral inhibition in the adult population(AU)

New dimensions in the use of rodent behavioral tests for novel drug discovery and development.

INTRODUCTION: Dimensional models of psychopathology describe mental illness in terms of natural variance along certain phenotypic dimensions that are continuous with normal. Vulnerability to psychopathology might arise when certain adaptive psychophysiological processes, conserved between humans and non-human animals, function outside of their "normal" range. Therefore, an in-depth understanding of the neurobiology and neurochemistry underlying these processes could identify possible novel drug targets. AREAS COVERED: Psychophysiological processes that might be related to anxiety disorders and depression are proposed and discussed. Those processes relevant to depressive disorders include: hedonic responsiveness, biases in the processing of stimuli, and sleep architecture. Those relevant to anxiety disorders include: startle reactivity, CO2 sensitivity, and fear generalization. Rodent behavioral tests for assessing the function of these processes and investigating their neurobiology are described. A psychophysiological process strategy for translational research is proposed, which focusses on understanding the neurobiology and neurochemistry underlying key psychophysiological processes that, when their activity deviates from normal, are associated with neuropsychiatric symptoms. This strategy emphasizes the use of analogous tests and measures in both preclinical and clinical studies, while de-emphasizing the use of preclinical animal models that attempt to replicate features of the neuropsychiatric disorder through experimental manipulations. EXPERT OPINION: Investigating the neurobiology of key psychophysiological processes in rodents should enhance our understanding of the pathophysiology of neuropsychiatric disorders. New drug development could be directed toward developing pharmacological strategies that would normalize the function of these psychophysiological processes.

The association between 5-HTTLPR gene polymorphism and behavioral inhibition in Chinese toddlers.

As one of the fundamental individual characteristics, behavioral inhibition in early childhood has considerable implications for the development of social, cognitive, and psychological adjustment. The purpose of this study was to examine the relation between the 5-HTTLPR polymorphism and behavioral inhibition in Chinese children using a cross-sectional design. A sample of 263 2-year-old children (134 boys and 129 girls of Han ethnicity; ages ranging from 24 to 26 months) in China participated in the study. Behavioral inhibition was assessed through laboratory observations, and genomic DNA was collected with buccal swabs. The results of analysis of covariance (ANCOVA) indicated that the homozygous short 5-HTTLPR allele was associated with lower levels of behavioral inhibition, which was different from most of the findings based on individuals in Western countries. The results suggest that social and cultural factors may be involved in shaping links between the 5-HTTLPR polymorphism and children's specific behaviors.

Propriedades psicométricas da versão brasileira do behavioral inhibition instrument (BII) e associações com sintomas psicopatológicos / Psychometric properties of the brazilian version of the behavioral inhibition instrument (BII) and associations with psychopathological symptoms / Propiedades psicométricas de la versión brasileña del behavioral inhibition instrument (BII) e sus asociaciones con síntomas psicopatológicos

Os objetivos desse estudo foram investigar propriedades psicométricas da versão brasileira do Behavioral Inhibition Instrument (BII) e suas associações com sintomas de ansiedade e depressão em crianças e adolescentes. Participaram 838 estudantes com idades entre 9-18 anos (M=12,89; DP=2,10) de uma amostra comunitária respondendo a versão brasileira do BII e questionários de autorrelato de sintomas de ansiedade e depressão. Os resultados demonstraram que a prevalência de crianças e adolescentes na categoria de alta inibição comportamental foi de 16,6%. O BII apresentou propriedades psicométricas satisfatórias com maiores níveis de inibição comportamental correlacionados a maiores níveis de sintomas de ansiedade e depressão, especialmente para sintomas de fobia social. Além disso, participantes com altos escores de inibição comportamental tiveram maior probabilidade de apresentar sintomas de ansiedade em um espectro clínico ou subclínico, especialmente para fobia social. Implicações para intervenções preventivas precoces são brevemente discutidas...

The aims of this study were to investigate psychometric properties of the Behavioral Inhibition Instrument (BII) and their association with depression and anxiety symptoms in children and adolescents. Eight hundred and thirty-eight students aged 9-18 years (M=12.89, SD=2.10) from a community sample answered the Brazilian-Portuguese version of the BII and self-report questionnaires of depression and anxiety symptoms. Results showed the prevalence of children and adolescents in the high behavioral inhibition (BI) category was 16.6%. The BII presented satisfactory psychometric properties with higher levels of BI being correlated to higher levels of depression and anxiety symptoms, especially social phobia symptoms. Also participants with higher BI scores were more likely to present anxiety symptoms in a subclinical or clinical range, especially for social phobia. Implications for early preventive interventions are briefly discussed...

Los objetivos de este estudio fueron investigar las propiedades psicométricas de la versión brasileña del Behavioral Inhibition Instrument (BII) y sus asociaciones con los síntomas de ansiedad y depresión en niños y adolescentes. Ochocientos treinta y ocho (838) estudiantes con edades entre 9 y 18 años (M=12,89; DP=2,10) de una muestra comunitaria respondieron a la versión brasileña del BII y a cuestionarios auto-aplicables de síntomas de ansiedad y depresión. Los resultados demuestran que el predominio de niños y adolescentes en la categoría de alta inhibición conductual fue de 16,6%. El BII presentó propiedades psicométricas satisfactorias con mayores niveles de inhibición conductual correlacionándose a mayores niveles de síntomas de ansiedad y depresión, especialmente para fobia social. Además, los participantes con altos puntajes de inhibición conductual tuvieron mayor probabilidad de presentar síntomas de ansiedad en un espectro clínico o subclínico, especialmente para fobia social. Algunas implicancias para realizar intervenciones preventivas precoces son brevemente discutidas...

Inhibición conductual y su relación con los trastornos de ansiedad infantil / Behavioral inhibition and relationship with childhood anxiety disorders

La literatura científica ha mostrado que la inhibición conductual (IC) se caracteriza por la presencia de ansiedad ante estímulos desconocidos, lo que conlleva conductas de retraimiento y evitación social. El presente estudio realiza una revisión bibliográfica sobre la IC y su relación con los trastornos de ansiedad en la infancia. Dado que la IC puede observarse en edades muy tempranas, la literatura ha examinado su papel predictor en el desarrollo de trastornos de ansiedad. Pese a ello, los estudios revisados apuntan a que no todos los niños ansiosos muestran un comportamiento inhibido ni todos los niños con IC sufren trastornos de ansiedad. Dada esta disparidad, sería necesario estudiar qué otros factores están implicados. Asimismo, los datos apuntan a que una detección precoz de la IC permitiría desarrollar programas de prevención de los trastornos de ansiedad en la infancia.

The literature has revealed that Behavioral inhibition (BI) is characterized by the presence of anxiety to unknown stimuli, which leads to withdrawal behaviors and social avoidance. The present study is aimed at revising the state-of-the-art on BI and examining its role that plays of childhood anxiety disorders. As the IB can be observed at very early ages, the literature has examined its predictive role in the development of anxiety disorders. Despite this, the reviewed studies suggest that not all anxious children show comorbid BI nor all inhibited children have anxiety disorders. Given this disparity, it would be necessary to consider what other factors are involved in the anxiety disorders. Furthermore, the data suggest that early detection of the BI would contribute to develop prevention programs for anxiety disorders in childhood.